Biochemical Evolution of a Potent Target of Mosquito Larvicide, 3-Hydroxykynurenine Transaminase [PDF]
Molecules, 2022 A specific mosquito enzyme, 3-hydroxykynurenine transaminase (HKT), is involved in the processing of toxic metabolic intermediates of the tryptophan metabolic pathway.
Huaqing Chen +4 more
doaj +2 more sources
Modulating the Kynurenine pathway or sequestering toxic 3-hydroxykynurenine protects the retina from light-induced damage in Drosophila. [PDF]
PLoS Genetics, 2023 Tissue health is regulated by a myriad of exogenous or endogenous factors. Here we investigated the role of the conserved Kynurenine pathway (KP) in maintaining retinal homeostasis in the context of light stress in Drosophila melanogaster.
Sarita Hebbar +3 more
doaj +4 more sources
Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis [PDF]
Cell Reports, 2023 Summary: Kynurenine monooxygenase (KMO) blockade protects against multiple organ failure caused by acute pancreatitis (AP), but the link between KMO and systemic inflammation has eluded discovery until now.
Alastair J. Hayes +19 more
doaj +4 more sources
3-Hydroxykynurenine in Regulation of Drosophila Behavior: The Novel Mechanisms for Cardinal Phenotype Manifestations [PDF]
Frontiers in Physiology, 2020 Dysfunctions of kynurenine pathway of tryptophan metabolism (KPTM) are associated with multiple neuropathologies in vertebrates and invertebrates.
Aleksandr V. Zhuravlev +5 more
doaj +2 more sources
Early detection of feline chronic kidney disease via 3-hydroxykynurenine and machine learning [PDF]
Scientific ReportsFeline chronic kidney disease (CKD) is one of the most frequently encountered diseases in veterinary practice, and the leading cause of mortality in cats over five years of age. While diagnosing advanced CKD is straightforward, current routine tests fail
Ellen Vanden Broecke +5 more
doaj +2 more sources
Molecular docking and molecular dynamics simulation studies of inhibitor candidates against Anopheles gambiae 3-hydroxykynurenine transaminase and implications on vector control [PDF]
HeliyonIsoxazole and oxadiazole derivatives inhibiting 3-hydroxykynurenine transaminase (3HKT) are potential larvicidal candidates. This study aims to identify more suited potential inhibitors of Anopheles gambiae 3HKT (Ag3HKT) through molecular docking and ...
Eunice O. Adedeji +6 more
doaj +2 more sources
3-Hydroxykynurenine Toxicity on the Rat Striatum In Vivo
The Japanese Journal of Pharmacology, 1996 3-Hydroxykynurenine (3-HK) is a tryptophan metabolite whose level in the brain is elevated under several pathological states including Huntington's disease. In the present study, we examined the possible toxicity of 3-HK by injection of this substance into rat brain.
Yasuhiro Nakagami, Hiroshi Katsuki
exaly +4 more sources
Postoperative Serum Quinolinic Acid and 3-Hydroxykynurenine in Dogs with Congenital Portosystemic Shunt: A Pilot Study of Their Association with Postattenuation Neurologic Signs [PDF]
Veterinary SciencesPostattenuation neurologic signs (PANS) are serious complications following surgical ligation of congenital portosystemic shunts (cPSS) in dogs, but their pathogenesis remains incompletely understood. We hypothesized that surgical ligation alters hepatic
Shoma Mikawa +2 more
doaj +2 more sources
Structure and mechanism of an antibiotics-synthesizing 3-hydroxykynurenine C-methyltransferase. [PDF]
Sci Rep, 2015 AbstractStreptosporangium sibiricum SibL catalyzes the methyl transfer from S-adenosylmethionine (SAM) to 3-hydroxykynurenine (3-HK) to produce S-adenosylhomocysteine (SAH) and 3-hydroxy-4-methyl-kynurenine for sibiromycin biosynthesis. Here, we present the crystal structures of apo-form Ss-SibL, Ss-SibL/SAH binary complex and Ss-SibL/SAH/3-HK ternary ...
Chen SC +9 more
europepmc +4 more sources
Physicochemical Characterization of Kynurenine Pathway Metabolites [PDF]
AntioxidantsThe kynurenine pathway is a significant metabolic route involved in the catabolism of tryptophan, producing various bioactive metabolites with crucial roles as antioxidants in immune regulation and neurobiology.
Luca Buzásy +7 more
doaj +2 more sources