Biochemical Evolution of a Potent Target of Mosquito Larvicide, 3-Hydroxykynurenine Transaminase [PDF]
Molecules, 2022 A specific mosquito enzyme, 3-hydroxykynurenine transaminase (HKT), is involved in the processing of toxic metabolic intermediates of the tryptophan metabolic pathway.
Huaqing Chen +4 more
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Modulating the Kynurenine pathway or sequestering toxic 3-hydroxykynurenine protects the retina from light-induced damage in Drosophila. [PDF]
PLoS Genetics, 2023 Tissue health is regulated by a myriad of exogenous or endogenous factors. Here we investigated the role of the conserved Kynurenine pathway (KP) in maintaining retinal homeostasis in the context of light stress in Drosophila melanogaster.
Sarita Hebbar +3 more
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3-Hydroxykynurenine in Regulation of Drosophila Behavior: The Novel Mechanisms for Cardinal Phenotype Manifestations [PDF]
Frontiers in Physiology, 2020 Dysfunctions of kynurenine pathway of tryptophan metabolism (KPTM) are associated with multiple neuropathologies in vertebrates and invertebrates.
Aleksandr V. Zhuravlev +5 more
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Early detection of feline chronic kidney disease via 3-hydroxykynurenine and machine learning [PDF]
Scientific ReportsFeline chronic kidney disease (CKD) is one of the most frequently encountered diseases in veterinary practice, and the leading cause of mortality in cats over five years of age. While diagnosing advanced CKD is straightforward, current routine tests fail
Ellen Vanden Broecke +5 more
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Molecular docking and molecular dynamics simulation studies of inhibitor candidates against Anopheles gambiae 3-hydroxykynurenine transaminase and implications on vector control [PDF]
HeliyonIsoxazole and oxadiazole derivatives inhibiting 3-hydroxykynurenine transaminase (3HKT) are potential larvicidal candidates. This study aims to identify more suited potential inhibitors of Anopheles gambiae 3HKT (Ag3HKT) through molecular docking and ...
Eunice O. Adedeji +6 more
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Physicochemical Characterization of Kynurenine Pathway Metabolites [PDF]
AntioxidantsThe kynurenine pathway is a significant metabolic route involved in the catabolism of tryptophan, producing various bioactive metabolites with crucial roles as antioxidants in immune regulation and neurobiology.
Luca Buzásy +7 more
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Reduced plasma concentrations of vitamin B6 and increased plasma concentrations of the neurotoxin 3-hydroxykynurenine are associated with nodding syndrome: a case control study in Gulu and Amuru districts, Northern Uganda [PDF]
The Pan African Medical Journal, 2016 INTRODUCTION: nodding syndrome was first reported in Uganda in 2003 among internally displaced populations. Risk factors for the syndrome remain unknown.
James Henry Obol +6 more
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Pregnancy complications affect kynurenine pathway metabolite concentrations in umbilical cord blood [PDF]
Reproductive Biology and EndocrinologyBackground Tryptophan and its kynurenine pathway (KP) metabolites play key roles in modulating the immune system and vasculature, and exhibit both pro- and antioxidant properties, making them crucial for a healthy pregnancy and fetal development ...
Michelle Broekhuizen +10 more
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Metabolic alterations in diabetic patients: aqueous humor profiling for biomarker discovery [PDF]
Amino AcidsDiabetic retinopathy, a leading cause of vision loss in working-age populations, is a severe complication of diabetes mellitus. Metabolomics, a key approach in systems biology, offers insights into the complex pathophysiology of diabetes by analyzing low-
Arturs Zemitis +6 more
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Tryptophan metabolites clearance in hemodialyzed patients [PDF]
Amino AcidsHemodialysis (HD) and hemodiafiltration (HDF) procedures have limited efficacy regarding removal of selected toxins. Tryptophan (Trp) metabolites formed through the kynurenine (KYN) pathway are known to contribute to kidney failure (KF) complications ...
Izabela Zakrocka +8 more
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