Results 41 to 50 of about 5,521 (201)

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice [PDF]

, 2014
Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects cellular lipid profiles.
Jové, Mariona, Naudí, Alba, Pamplona, Reinald, Portero-Otín, Manuel, Ramírez-Núñez, Omar, Selman, Colin, Withers, Dominic J.   +6 more
core   +3 more sources

Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder - Possible Role for Methoxyindole Pathway [PDF]

, 2013
10.1371/journal.pone.0068283PLoS ONE87 ...
A Hale, AL van Bemmel, AM Galzin, AR Brunoni, BE Leonard, BS Kristal, BT Walsh, CG Schipke, D Healy, DA Marsteller, DC Steffens, DJ Nutt, DJ Nutt, DN Thomas, DS Charney, E Dremencov, Erik Churchill, ES Rom-Bugoslavskaia, Eve Pickering, F Zhang, FP Bymaster, G Sanacora, GM Mackay, GM Sullivan, GS Malhi, Hongjie Zhu, I Kirsch, I Kostoglou-Athanassiou, J Beck-Friis, Jacob Guy Bundy, JC Alvarez, JD Storey, John A. Rush, K Golembiowska, KJ Ressler, KK Johansen, LA Paige, M Bogdanov, M Catena-Dell'Osso, M Di Giannantonio, M Di Mascio, MA Hofman, Marielle Delnomdedieu, MH Trivedi, Mikhail B. Bogdanov, MJ Millan, MM Katz, Oliver Fiehn, P Pevet, Pharmacometabolomics Research Network, R Kaddurah-Daouk, Ranga R. Krishnan, Rima Kaddurah-Daouk, RL Gannon, S Kasper, S Rozen, Samantha Matson, SJ Wang, Stephen H. Boyle, SW Jang, Swati Sharma, T Uz, TR Insel, Wayne Matson, WC Duncan Jr, Y Bismuth-Evenzal, Y Ji, Y Kitaichi, Z Bhagwagar, Z Gorka   +69 more
core   +8 more sources

Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia [PDF]

, 2013
Background: Excessive tryptophan metabolism to kynurenine by the rate-limiting enzyme endothelial indoleamine 2,3-dioxygenase 1 (IDO) controls arterial vessel relaxation and causes hypotension in murine endotoxemia.
Bode-Böger, S.M. (Stefanie), Kielstein, J.T. (Jan), Kovesdy, C.P. (Csaba), Kümpers, P. (Philipp), Martens-Lobenhoffer, J. (Jens), Meurs, M. (Matijs) van, Padberg, J. (Jan), Zijlstra, J.G. (Jan)   +7 more
core   +2 more sources

Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase [PDF]

Proceedings of the National Academy of Sciences, 2006
In Anopheles gambiae , the vector for the most deadly malaria parasite Plasmodium falciparum , xanthurenic acid (XA) plays a key role in parasite gametogenesis and fertility. In mosquitoes, XA is produced by transamination of 3-hydroxykynurenine (3-HK), a reaction that represents the main ...
F. Rossi, S. Garaviglia, G. B. Giovenzana, ARCA', Bruno, J. Li, M. Rizzi   +5 more
openaire   +5 more sources

Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites

EBioMedicine, 2022
Summary: Background: Neuroinflammatory diseases such as encephalitis, meningitis, multiple sclerosis and other neurological diseases with inflammatory components, have demonstrated a need for diagnostic biomarkers to define treatable and reversible ...
Jingya Yan, Velda X. Han, Benjamin Heng, Gilles J. Guillemin, Sushil Bandodkar, Russell C. Dale   +5 more
doaj   +1 more source

Kynurenines link chronic inflammation to functional decline and physical frailty

JCI Insight, 2020
Chronic inflammation is associated with physical frailty and functional decline in older adults; however, the molecular mechanisms of this linkage are not understood.
Reyhan Westbrook, Tae Chung, Jacqueline Lovett, Chris Ward, Humberto Joca, Huanle Yang, Mohammed Khadeer, Jing Tian, Qian-Li Xue, Anne Le, Luigi Ferrucci, Ruin Moaddel, Rafa de Cabo, Ahmet Hoke, Jeremy Walston, Peter M. Abadir   +15 more
doaj   +1 more source

The Influence of Exercise Intensity on Tryptophan Metabolites in Thoroughbred Horses

Pharmaceuticals, 2023
Catabolism of tryptophan (Trp) is modulated by physical activity and provides a pool of active compounds: Trp is considered a calmative agent, kynurenine (Kyn) and 3-hydroxykynurenine (3-HKyn) show neurotoxic effects, kynurenic acid (Kyna) and ...
Magdalena Staniszewska, Sylwester Kowalik, Ilona Sadok, Witold Kędzierski   +3 more
doaj   +1 more source

Fast and low-cost evaluation of hydroxykynurenine activity

MethodsX, 2020
The enzyme 3-hydroxykynurenine transaminase (HKT) acts as an important enzyme in tryptophan catabolism of disease-carrier insects, e.g. Aedes aegypti and Anopheles gambiae. HKT is a detoxification enzyme that converts 3-hydroxykynurenine (a precursor for
Larissa G. Maciel, Janaína V. dos Anjos, Thereza A. Soares   +2 more
doaj   +1 more source

Biosynthetic rivalry of o-aminophenol-carboxylic acids initiates production of hemi-actinomycins in Streptomyces antibioticus [PDF]

, 2014
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Crnovčić, Ivana, Keller, Ullrich, Semsary, Siamak, Vater, Joachim   +3 more
core   +1 more source

Blood plasma B vitamins in depression and the therapeutic response to electroconvulsive therapy

Brain, Behavior, & Immunity - Health, 2020
A growing body of research has indicated a role for B vitamins in depression, with some previous studies suggesting that B vitamin status in patients with depression can impact on antidepressant response.
Karen M. Ryan, Kelly A. Allers, Andrew Harkin, Declan M. McLoughlin   +3 more
doaj   +1 more source