Results 41 to 50 of about 5,596 (203)

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice [PDF]

, 2014
Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects cellular lipid profiles.
Jové, Mariona, Naudí, Alba, Pamplona, Reinald, Portero-Otín, Manuel, Ramírez-Núñez, Omar, Selman, Colin, Withers, Dominic J.   +6 more
core   +3 more sources

Polypeptide Modification and Cross-Linking by Oxidized 3-Hydroxykynurenine [PDF]

Biochemistry, 2000
3-Hydroxykynurenine (3OHKyn) is present in the mammalian lens as a UV filter and is formed from kynurenine in the tryptophan metabolic pathway. 3OHKyn is a readily autoxidized o-aminophenol which binds to proteins in vitro. The lens, particularly its central region, the nucleus, becomes increasingly oxidized with age.
Aquilina, J., Carver, J., Truscott, R.
  +9 more sources

Increased indoleamine-2,3-dioxygenase activity is associated with poor clinical outcome in adults hospitalized with influenza in the INSIGHT FLU003Plus study [PDF]

, 2017
BACKGROUND: Indoleamine-2,3-dioxygenase (IDO) mediated tryptophan (TRP) depletion has antimicrobial and immuno-regulatory effects. Increased kynurenine (KYN)-to-TRP (KT) ratios, reflecting increased IDO activity, have been associated with poorer ...
Aagaard, B, Anagnostou, O, Angus, B, Baker, J, Baxter, J, Beigel, J, Beilke, M, Belloso, W, Bennet, R, Bertrand, M, Brekke, K, Brown, S, Campbell, M, Carbonneau, J, Clark, L, Coburn, P, Collaco Moraes, Y, Cooper, D, Courtney-Rogers, D, Davey, RT, Delfino, M, Denning, E, Dewar, R, Dharan, N, DuChene, A, Dwyer, D, Dwyer, DE, Emery, S, Engen, N, Faber, L, Freiberg, M, George, M, Gioukari, V, Glesby, M, Gordin, F, Gover, E, Griffin, TJ, Gunderson, E, Gunter, J, Ham, K, Harrison, M, Herrero, P, Hodgson, SW, Hoover, M, Hudson, F, Jansson, P, Kaewon, P, Kalomenidis, I, Koerbel, G, Kok, J, Kunisaki, KM, La Rosa, A, Lopez, P, Losso, M, Lu, Z, Lundgren, J, Markowitz, N, McConnell, R, Metcalf, J, Moricz, A, Munroe, D, Nahra, R, Natarajan, V, Neaton, JD, Nelson, R, Novak, R, Omotosho, J, Pacciarini, F, Paez, A, Paez-Quinde, M, Parenti, D, Patil, N, Paton, N, Pearson, M, Pett, SL, Polenakovik, H, Portas, B, Quan, SF, Rehman, T, Riska, P, Rizza, S, Robson, R, Ruxrungtham, K, Saenz, MJ, Sanchez, A, Sanchez, RM, Schultz, T, Schwarber, M, Simon, G, Standridge, B, Temesgen, Z, Tillmann, K, Touloumi, G, Ubolyam, S, Uyeki, T, Vjecha, M, Voell, J, Wendt, CH, Wentworth, D, Wolfe, C   +99 more
core   +2 more sources

Gourami Lenses Convert Tryptophan into 3-Hydroxykynurenine

Ophthalmic Research, 2009
Although free tryptophan was found in the lens of both the kissing gourami (Helostoma temmincki) and the 3-spot gourami (Trichogaster trichopterus), only the lens of the latter species contained 3-hydroxykynurenine. Radiolabel experiments carried out on 3-spot gourami lenses in culture demonstrated that, as in humans, lenticular tryptophan is converted
R J, Truscott, A M, Wood
openaire   +2 more sources

Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder - Possible Role for Methoxyindole Pathway [PDF]

, 2013
10.1371/journal.pone.0068283PLoS ONE87 ...
A Hale, AL van Bemmel, AM Galzin, AR Brunoni, BE Leonard, BS Kristal, BT Walsh, CG Schipke, D Healy, DA Marsteller, DC Steffens, DJ Nutt, DJ Nutt, DN Thomas, DS Charney, E Dremencov, Erik Churchill, ES Rom-Bugoslavskaia, Eve Pickering, F Zhang, FP Bymaster, G Sanacora, GM Mackay, GM Sullivan, GS Malhi, Hongjie Zhu, I Kirsch, I Kostoglou-Athanassiou, J Beck-Friis, Jacob Guy Bundy, JC Alvarez, JD Storey, John A. Rush, K Golembiowska, KJ Ressler, KK Johansen, LA Paige, M Bogdanov, M Catena-Dell'Osso, M Di Giannantonio, M Di Mascio, MA Hofman, Marielle Delnomdedieu, MH Trivedi, Mikhail B. Bogdanov, MJ Millan, MM Katz, Oliver Fiehn, P Pevet, Pharmacometabolomics Research Network, R Kaddurah-Daouk, Ranga R. Krishnan, Rima Kaddurah-Daouk, RL Gannon, S Kasper, S Rozen, Samantha Matson, SJ Wang, Stephen H. Boyle, SW Jang, Swati Sharma, T Uz, TR Insel, Wayne Matson, WC Duncan Jr, Y Bismuth-Evenzal, Y Ji, Y Kitaichi, Z Bhagwagar, Z Gorka   +69 more
core   +8 more sources

Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites

EBioMedicine, 2022
Summary: Background: Neuroinflammatory diseases such as encephalitis, meningitis, multiple sclerosis and other neurological diseases with inflammatory components, have demonstrated a need for diagnostic biomarkers to define treatable and reversible ...
Jingya Yan, Velda X. Han, Benjamin Heng, Gilles J. Guillemin, Sushil Bandodkar, Russell C. Dale   +5 more
doaj   +1 more source

Biosynthetic rivalry of o-aminophenol-carboxylic acids initiates production of hemi-actinomycins in Streptomyces antibioticus [PDF]

, 2014
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Crnovčić, Ivana, Keller, Ullrich, Semsary, Siamak, Vater, Joachim   +3 more
core   +1 more source

Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia [PDF]

, 2013
Background: Excessive tryptophan metabolism to kynurenine by the rate-limiting enzyme endothelial indoleamine 2,3-dioxygenase 1 (IDO) controls arterial vessel relaxation and causes hypotension in murine endotoxemia.
Bode-Böger, S.M. (Stefanie), Kielstein, J.T. (Jan), Kovesdy, C.P. (Csaba), Kümpers, P. (Philipp), Martens-Lobenhoffer, J. (Jens), Meurs, M. (Matijs) van, Padberg, J. (Jan), Zijlstra, J.G. (Jan)   +7 more
core   +2 more sources

Kynurenines link chronic inflammation to functional decline and physical frailty

JCI Insight, 2020
Chronic inflammation is associated with physical frailty and functional decline in older adults; however, the molecular mechanisms of this linkage are not understood.
Reyhan Westbrook, Tae Chung, Jacqueline Lovett, Chris Ward, Humberto Joca, Huanle Yang, Mohammed Khadeer, Jing Tian, Qian-Li Xue, Anne Le, Luigi Ferrucci, Ruin Moaddel, Rafa de Cabo, Ahmet Hoke, Jeremy Walston, Peter M. Abadir   +15 more
doaj   +1 more source

Fast and low-cost evaluation of hydroxykynurenine activity

MethodsX, 2020
The enzyme 3-hydroxykynurenine transaminase (HKT) acts as an important enzyme in tryptophan catabolism of disease-carrier insects, e.g. Aedes aegypti and Anopheles gambiae. HKT is a detoxification enzyme that converts 3-hydroxykynurenine (a precursor for
Larissa G. Maciel, Janaína V. dos Anjos, Thereza A. Soares   +2 more
doaj   +1 more source