Results 41 to 50 of about 3,496 (164)
Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease
Neurobiology of Disease, 2004 Huntington's disease (HD), an inherited neurodegenerative disorder, is caused by an abnormal polyglutamine expansion in the huntingtin protein. This genetic defect may result in heightened neuronal susceptibility to excitotoxic injury, a mechanism that ...
Paolo Guidetti +3 more
doaj +1 more source
A six-metabolite panel as potential blood-based biomarkers for Parkinson’s disease
npj Parkinson's Disease, 2021 Characterisation and diagnosis of idiopathic Parkinson’s disease (iPD) is a current challenge that hampers both clinical assessment and clinical trial development with the potential inclusion of non-PD cases.
Stephan Klatt +6 more
doaj +1 more source
The Influence of Kynurenine and Its Metabolites on Lipid Metabolism
Pteridines, 1997 Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver tissue homogenate, Krebs-Ringer-phosphate buffer (pH=7.4) containing 0.3% albumin, fatty acid mixture and glycerol.
Rudzite Vera +6 more
doaj +1 more source
Neurobiology of Disease, 2006 Pneumococcal meningitis (PM) is characterized by an intense inflammatory host reaction that contributes to the development of cortical necrosis and hippocampal apoptosis.
Caroline L. Bellac +3 more
doaj +1 more source
Altered Cerebrospinal Fluid Tryptophan–Kynurenine Pathway Metabolism in Multiple System Atrophy
Movement Disorders, EarlyView.Abstract Background Alterations in tryptophan–kynurenine (TRP‐KYN) metabolism, which is associated with neuroinflammation, remain unclear in multiple system atrophy (MSA). Objective The aim was to investigate cerebrospinal fluid (CSF) TRP metabolites in MSA and their associations with other biomarkers.
Ryunosuke Nagao +8 more
wiley +1 more source
Tryptophan Catabolism and Inflammation: A Novel Therapeutic Target For Aortic Diseases
Frontiers in Immunology, 2021 Aortic diseases are the primary public health concern. As asymptomatic diseases, abdominal aortic aneurysm (AAA) and atherosclerosis are associated with high morbidity and mortality.
Tharmarajan Ramprasath +4 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Opioid use disorder, particularly involving fentanyl, poses major challenges due to high relapse rates and limited effectiveness of pharmacotherapies. The kynurenine pathway has emerged as a target for addiction treatment through its modulation of glutamatergic and dopaminergic neurotransmission.
Carlos Núñez‐de la Calle +12 more
wiley +1 more source
Hepatology Research, EarlyView.IDO‐1 immunostaining identifies primary biliary cholangitis even in morphologically subtle bile duct lesions. IDO‐1 expression reflects cholangitis activity and is suppressed by ursodeoxycholic acid treatment, indicating its value as a dynamic diagnostic adjunct rather than a static marker of chronic damage.
Kaori Yoshimura +10 more
wiley +1 more source
Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.1. Indoleamine 2,3‐dioxygenase (IDO) acts as a time‐dependent metabolic–immune switch in the acute kidney injury‐to‐chronic kidney disease transition, protective early but pathogenic when sustained. 2. Early protection (regulatory T cell expansion, M2 polarisation and ferroptosis suppression) gives way to general control nonderepressible 2‐driven ...
Ziyi Qiu, Binbin Pan
wiley +1 more source
Cellular Localization of Kynurenine 3-Monooxygenase in the Brain: Challenging the Dogma
Antioxidants, 2022 Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of tryptophan degradation, regulates the synthesis of the neuroactive metabolites 3-hydroxykynurenine (3-HK) and kynurenic acid (KYNA).
Korrapati V. Sathyasaikumar +10 more
doaj +1 more source