Results 31 to 40 of about 3,496 (164)
Exploration of urinary metabolite dynamicity for early detection of pregnancy in water buffaloes
Scientific Reports, 2022 Early and precise pregnancy diagnosis can reduce the calving interval by minimizing postpartum period. The present study explored the differential urinary metabolites between pregnant and non-pregnant Murrah buffaloes (Bubalus bubalis) during early ...
Archana Sarangi +10 more
doaj +1 more source
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice
Neurobiology of Disease, 2006 The brain levels of the endogenous excitotoxin quinolinic acid (QUIN) and its bioprecursor, the free radical generator 3-hydroxykynurenine (3-HK), are elevated in early stage Huntington disease (HD).
Paolo Guidetti +9 more
doaj +1 more source
Polypeptide Modification and Cross-Linking by Oxidized 3-Hydroxykynurenine [PDF]
Biochemistry, 2000 3-Hydroxykynurenine (3OHKyn) is present in the mammalian lens as a UV filter and is formed from kynurenine in the tryptophan metabolic pathway. 3OHKyn is a readily autoxidized o-aminophenol which binds to proteins in vitro. The lens, particularly its central region, the nucleus, becomes increasingly oxidized with age.
Aquilina, J., Carver, J., Truscott, R.
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Gourami Lenses Convert Tryptophan into 3-Hydroxykynurenine
Ophthalmic Research, 2009 Although free tryptophan was found in the lens of both the kissing gourami (Helostoma temmincki) and the 3-spot gourami (Trichogaster trichopterus), only the lens of the latter species contained 3-hydroxykynurenine. Radiolabel experiments carried out on 3-spot gourami lenses in culture demonstrated that, as in humans, lenticular tryptophan is converted
R J, Truscott, A M, Wood
openaire +2 more sources
Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase [PDF]
Proceedings of the National Academy of Sciences, 2006 In Anopheles gambiae , the vector for the most deadly malaria parasite Plasmodium falciparum , xanthurenic acid (XA) plays a key role in parasite gametogenesis and fertility. In mosquitoes, XA is produced by transamination of 3-hydroxykynurenine (3-HK),
ROSSI, Franca +5 more
openaire +6 more sources
Kynurenines link chronic inflammation to functional decline and physical frailty
JCI Insight, 2020 Chronic inflammation is associated with physical frailty and functional decline in older adults; however, the molecular mechanisms of this linkage are not understood.
Reyhan Westbrook +15 more
doaj +1 more source
Fast and low-cost evaluation of hydroxykynurenine activity
MethodsX, 2020 The enzyme 3-hydroxykynurenine transaminase (HKT) acts as an important enzyme in tryptophan catabolism of disease-carrier insects, e.g. Aedes aegypti and Anopheles gambiae. HKT is a detoxification enzyme that converts 3-hydroxykynurenine (a precursor for
Larissa G. Maciel +2 more
doaj +1 more source
EBioMedicine, 2022 Summary: Background: Neuroinflammatory diseases such as encephalitis, meningitis, multiple sclerosis and other neurological diseases with inflammatory components, have demonstrated a need for diagnostic biomarkers to define treatable and reversible ...
Jingya Yan +5 more
doaj +1 more source
Blood plasma B vitamins in depression and the therapeutic response to electroconvulsive therapy
Brain, Behavior, & Immunity - Health, 2020 A growing body of research has indicated a role for B vitamins in depression, with some previous studies suggesting that B vitamin status in patients with depression can impact on antidepressant response.
Karen M. Ryan +3 more
doaj +1 more source
The Influence of Exercise Intensity on Tryptophan Metabolites in Thoroughbred Horses
Pharmaceuticals, 2023 Catabolism of tryptophan (Trp) is modulated by physical activity and provides a pool of active compounds: Trp is considered a calmative agent, kynurenine (Kyn) and 3-hydroxykynurenine (3-HKyn) show neurotoxic effects, kynurenic acid (Kyna) and ...
Magdalena Staniszewska +3 more
doaj +1 more source