Results 31 to 40 of about 5,521 (201)

The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders [PDF]

, 2013
Understanding the neurochemical basis for cognitive function is one of the major goals of neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range of psychiatric and neurological disorders.
Akagbosu, Akladios, Alexander, Alkondon, Alkondon, Alkondon, Amori, Andersen, Atlas, Autier, Backman, Beal, Benatti, Bonda, Breese, Carpenedo, Carpenedo, Casazza, Castellano, Ceresoli-Borroni, Cesura, Chess, Chess, Chess, Chiarugi, Chiarugi, Clark, Cochran, Cozzi, Cui, Daily, Dalley, Dantzer, Darlington, Darlington, Davidson, Deiana, Della Torre, DiNatale, Dobelis, Dounay, Eastman, Erhardt, Forrest, Forrest, Forrest, Forrest, Fukui, Gellert, Giordani, Giorgini, Gold, Graef, Guidetti, Guidetti, Guidetti, Guidetti, Guillemin, Guillemin, Hardingham, Hedges, Henderson, Heng, Hernandez, Heyes, Hilmas, Holtze, Jason, Jauch, Jentsch, Jurgens, Kalisch, Kandanearatchi, Kiank, Kihara, Kloet, Kocki, Konradsson-Geuken, Lawrence, Lawrence, Linderholm, Lindsley, Luchowski, Luchowski, Lupien, Marin, Mexal, Millan, Miller, Minzenberg, Miura, Moeller, Mok, Muchowski, Muchowski, Mueller, Muscatell, Myint, Nagy, Neill, Newcomer, Newcomer, Nilsson, Nilsson, Nozaki, O'Connor, Olsson, Onur, Owe-Young, Paterson, Pearson, Pechtel, Pellicciari, Pellicciari, Perkins, Pertovaara, Pevarello, Phillips, Pocivavsek, Pocivavsek, Popoli, Popoli, Potter, Rahman, Raison, Rassoulpour, Ren, Robert, Rodgers, Rossi, Ryu, Röver, Saito, Salazar, Sapko, Sarter, Sathyasaikumar, Sathyasaikumar, Schwarcz, Schwarcz, Schwarcz, Schwarcz, Shear, Speciale, Speciale, Stazka, Stazka, Stone, Stone, Stone, Stone, Stone, Stoy, Tadaiesky, Tatter, Teichberg, Teichberg, Ting, Trecartin, Tse, Varasi, Vezzani, Walker, Wang, Wang, Wejksza, Wejksza, Wonodi, Xu, Yamada, Yuen, Zisapel, Zmarowski   +172 more
core   +1 more source

Gourami Lenses Convert Tryptophan into 3-Hydroxykynurenine

Ophthalmic Research, 1994
Although free tryptophan was found in the lens of both the kissing gourami (Helostoma temmincki) and the 3-spot gourami (Trichogaster trichopterus), only the lens of the latter species contained 3-hydroxykynurenine. Radiolabel experiments carried out on 3-spot gourami lenses in culture demonstrated that, as in humans, lenticular tryptophan is converted
R J, Truscott, A M, Wood
openaire   +2 more sources

Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important [PDF]

, 2015
Kynurenine pathway, the quantitatively main branch of tryptophan metabolism, has been long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to ...
CURTO, MARTINA, FAZIO, FRANCESCO, Lionetto, L, MARTELLETTI, Paolo, Mitsikostas, Dd   +4 more
core   +1 more source

Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19

Scientific Reports, 2022
SARS-CoV-2 causes major disturbances in serum metabolite levels, associated with severity of the immune response. Despite the numerous advantages of urine for biomarker discovery, the potential association between urine metabolites and disease severity ...
Joseph P. Dewulf, Manon Martin, Sandrine Marie, Fabie Oguz, Leila Belkhir, Julien De Greef, Jean Cyr Yombi, Xavier Wittebole, Pierre-François Laterre, Michel Jadoul, Laurent Gatto, Guido T. Bommer, Johann Morelle   +12 more
doaj   +1 more source

3-Hydroxykynurenine targets kainate receptors to promote defense against infection. [PDF]

Nat Chem Biol
Bacterial infection involves a complex interaction between the pathogen and host where the outcome of infection is not solely determined by pathogen eradication. To identify small molecules that promote host survival by altering the host-pathogen dynamic, we conducted an in vivo chemical screen using zebrafish embryos and found that treatment with 3 ...
Parada-Kusz M, Clatworthy AE, Goering ER, Blackwood SM, Shigeta JY, Mashin E, Salm EJ, Choi C, Combs S, Lee JSW, Rodriguez-Osorio C, Clish C, Tomita S, Hung DT.   +13 more
europepmc   +3 more sources

Magnesium and other biometals in oxidative medicine and redox biology [PDF]

, 2017
No abstract ...
Barbagallo, Mario, Kolisek, Martin, Romani, Andrea, Touyz, Rhian M.   +3 more
core   +3 more sources

Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]

, 2010
Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
Berfelo, M. W., Hulsman, J. A. R. J., Majoie, H. J. M., Myint, A., Rijkers, K., Schwarz, M., Vles, J. S. H.   +6 more
core   +2 more sources

Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology [PDF]

, 2015
Mounting evidence demonstrates that kynurenine metabolism may play an important pathogenic role in the development of multiple neurological and neuropsychiatric disorders.
Jason C. O’Connor, Jennifer M. Parrott
core   +2 more sources

Exploration of urinary metabolite dynamicity for early detection of pregnancy in water buffaloes

Scientific Reports, 2022
Early and precise pregnancy diagnosis can reduce the calving interval by minimizing postpartum period. The present study explored the differential urinary metabolites between pregnant and non-pregnant Murrah buffaloes (Bubalus bubalis) during early ...
Archana Sarangi, Mayukh Ghosh, Suman Sangwan, Rajesh Kumar, Sunesh Balhara, S. K. Phulia, R. K. Sharma, Subhasish Sahu, Sandeep Kumar, A. K. Mohanty, A. K. Balhara   +10 more
doaj   +1 more source

Increased indoleamine-2,3-dioxygenase activity is associated with poor clinical outcome in adults hospitalized with influenza in the INSIGHT FLU003Plus study [PDF]

, 2017
BACKGROUND: Indoleamine-2,3-dioxygenase (IDO) mediated tryptophan (TRP) depletion has antimicrobial and immuno-regulatory effects. Increased kynurenine (KYN)-to-TRP (KT) ratios, reflecting increased IDO activity, have been associated with poorer ...
Aagaard, B, Anagnostou, O, Angus, B, Baker, J, Baxter, J, Beigel, J, Beilke, M, Belloso, W, Bennet, R, Bertrand, M, Brekke, K, Brown, S, Campbell, M, Carbonneau, J, Clark, L, Coburn, P, Collaco Moraes, Y, Cooper, D, Courtney-Rogers, D, Davey, RT, Delfino, M, Denning, E, Dewar, R, Dharan, N, DuChene, A, Dwyer, D, Dwyer, DE, Emery, S, Engen, N, Faber, L, Freiberg, M, George, M, Gioukari, V, Glesby, M, Gordin, F, Gover, E, Griffin, TJ, Gunderson, E, Gunter, J, Ham, K, Harrison, M, Herrero, P, Hodgson, SW, Hoover, M, Hudson, F, Jansson, P, Kaewon, P, Kalomenidis, I, Koerbel, G, Kok, J, Kunisaki, KM, La Rosa, A, Lopez, P, Losso, M, Lu, Z, Lundgren, J, Markowitz, N, McConnell, R, Metcalf, J, Moricz, A, Munroe, D, Nahra, R, Natarajan, V, Neaton, JD, Nelson, R, Novak, R, Omotosho, J, Pacciarini, F, Paez, A, Paez-Quinde, M, Parenti, D, Patil, N, Paton, N, Pearson, M, Pett, SL, Polenakovik, H, Portas, B, Quan, SF, Rehman, T, Riska, P, Rizza, S, Robson, R, Ruxrungtham, K, Saenz, MJ, Sanchez, A, Sanchez, RM, Schultz, T, Schwarber, M, Simon, G, Standridge, B, Temesgen, Z, Tillmann, K, Touloumi, G, Ubolyam, S, Uyeki, T, Vjecha, M, Voell, J, Wendt, CH, Wentworth, D, Wolfe, C   +99 more
core   +2 more sources