The Influence of Exercise Intensity on Tryptophan Metabolites in Thoroughbred Horses
Pharmaceuticals, 2023 Catabolism of tryptophan (Trp) is modulated by physical activity and provides a pool of active compounds: Trp is considered a calmative agent, kynurenine (Kyn) and 3-hydroxykynurenine (3-HKyn) show neurotoxic effects, kynurenic acid (Kyna) and ...
Magdalena Staniszewska +3 more
doaj +1 more source
Blood plasma B vitamins in depression and the therapeutic response to electroconvulsive therapy
Brain, Behavior, & Immunity - Health, 2020 A growing body of research has indicated a role for B vitamins in depression, with some previous studies suggesting that B vitamin status in patients with depression can impact on antidepressant response.
Karen M. Ryan +3 more
doaj +1 more source
, 1951 The field under review is growing so rapidly that it is impossible to cover more than a sampling of recent papers in the allotted space. Important subjects such as the genetics and chemistry of viruses and certain topics in bacterial genetics have had ...
Horowitz, N. H., Mitchell, H. K.
core +1 more source
Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease
Neurobiology of Disease, 2004 Huntington's disease (HD), an inherited neurodegenerative disorder, is caused by an abnormal polyglutamine expansion in the huntingtin protein. This genetic defect may result in heightened neuronal susceptibility to excitotoxic injury, a mechanism that ...
Paolo Guidetti +3 more
doaj +1 more source
Pharmacometabonomics in humans: a new tool for personalized medicine [PDF]
, 2015 Pharmacogenomics is now over 50 years old and has had some impact in clinical practice, through its use to select patient subgroups who will enjoy efficacy without side effects when treated with certain drugs.
Claridge T, Jeremy R Everett, Lindon JC
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A six-metabolite panel as potential blood-based biomarkers for Parkinson’s disease
npj Parkinson's Disease, 2021 Characterisation and diagnosis of idiopathic Parkinson’s disease (iPD) is a current challenge that hampers both clinical assessment and clinical trial development with the potential inclusion of non-PD cases.
Stephan Klatt +6 more
doaj +1 more source
Untargeted metabolomics of colonic digests reveals kynurenine pathway metabolites, dityrosine and 3-dehydroxycarnitine as red versus white meat discriminating metabolites [PDF]
, 2016 Epidemiological research has demonstrated that the consumption of red meat is an important risk factor for the development of colorectal cancer (CRC), diabetes mellitus and cardiovascular diseases.
De Smet, S. +5 more
core +2 more sources
The Influence of Kynurenine and Its Metabolites on Lipid Metabolism
Pteridines, 1997 Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver tissue homogenate, Krebs-Ringer-phosphate buffer (pH=7.4) containing 0.3% albumin, fatty acid mixture and glycerol.
Rudzite Vera +6 more
doaj +1 more source
Tryptophan Catabolism and Inflammation: A Novel Therapeutic Target For Aortic Diseases
Frontiers in Immunology, 2021 Aortic diseases are the primary public health concern. As asymptomatic diseases, abdominal aortic aneurysm (AAA) and atherosclerosis are associated with high morbidity and mortality.
Tharmarajan Ramprasath +4 more
doaj +1 more source
Altered Cerebrospinal Fluid Tryptophan–Kynurenine Pathway Metabolism in Multiple System Atrophy
Movement Disorders, EarlyView.Abstract Background Alterations in tryptophan–kynurenine (TRP‐KYN) metabolism, which is associated with neuroinflammation, remain unclear in multiple system atrophy (MSA). Objective The aim was to investigate cerebrospinal fluid (CSF) TRP metabolites in MSA and their associations with other biomarkers.
Ryunosuke Nagao +8 more
wiley +1 more source