Results 51 to 60 of about 3,496 (164)

Multi‐Omics Analysis Identifies Tryptophan Metabolism and Glycolysis as Potential Pathways Involved in the Protective Effects of Tormentic Acid Against Metabolic Associated Fatty Liver Disease

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
TA alleviates MCD diet‐induced MAFLD, and this effect is associated with alterations in tryptophan metabolism and glycolysis. ABSTRACT Metabolic associated fatty liver disease (MAFLD) has high morbidity and tragically lacks effective therapeutic remedies.
Yuanyuan Wei, Dingyi Wei, Jingyang Lu, Lulin Wei, Weijia Lin, Jinbin Wei, Xiao Ma   +6 more
wiley   +1 more source

Metabolic Profiling of Rumen Fluid and Milk in Lactating Dairy Cattle Influenced by Subclinical Ketosis Using Proton Nuclear Magnetic Resonance Spectroscopy

Animals, 2021
Ketosis metabolic research on lactating dairy cattle has been conducted worldwide; however, there have been very few Korean studies. Biofluids from lactating dairy cattle are necessary to study ketosis metabolic diseases.
Jun-Sik Eom, Hyun-Sang Kim, Shin-Ja Lee, You-Young Choi, Seong-Uk Jo, Jaemin Kim, Sang-Suk Lee, Eun-Tae Kim, Sung-Sill Lee   +8 more
doaj   +1 more source

Biofluid Biomarkers of Cognitive Functioning in Bipolar Disorder: A Systematic Review by the Targeting Cognition and Older‐Age Bipolar Disorder ISBD Task Forces

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Background Cognitive impairment is common in bipolar disorder (BD), but the underlying pathophysiology remains unclear. This systematic review aimed to (1) summarize all literature describing relationships of biofluid biomarkers and cognition in BD and (2) identify which biofluid biomarkers correlate most consistently with cognition in BD ...
Alexandra J. M. Beunders, Sigfried N. T. M. Schouws, Andrew T. Olagunju, Vicent Balanzá‐Martínez, Nicole C. M. Korten, Ralph W. Kupka, Katherine E. Burdick, Andre F. Carvalho, Ariel G. Gildengers, Lars V. Kessing, Roger S. McIntyre, Paula V. Nunes, Ayal Schaffer, Ivan J. Torres, Shang‐Ying Tsai, Tamsyn E. Van Rheenen, Eduard Vieta, Lakshmi N. Yatham, Allan H. Young, Lisa T. Eyler, Kamilla W. Miskowiak, Annemiek Dols   +21 more
wiley   +1 more source

Oral Lysozyme Attenuates Neuroinflammation and Brain Injury After Traumatic Brain Injury Through Gut Microbiota‐Dependent Reprogramming of Tryptophan Metabolism

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Oral lysozyme reshapes gut microbiota‐dependent tryptophan metabolism, increasing neuroprotective metabolites like KYNA and restoring intestinal barrier integrity. This attenuates systemic inflammation and reprograms cerebral kynurenine metabolism toward the neuroprotective KYNA branch, reducing neuroinflammation and improving outcomes after traumatic ...
Zhuoying Du, Haijun Yao, Caihua Xi, Qiang Yuan, Pengfei Fu, Jin Hu, Gang Wu, Weijian Yang   +7 more
wiley   +1 more source

Chronic Treatment with the IDO1 Inhibitor 1-Methyl-D-Tryptophan Minimizes the Behavioural and Biochemical Abnormalities Induced by Unpredictable Chronic Mild Stress in Mice - Comparison with Fluoxetine. [PDF]

PLoS ONE, 2016
We demonstrated that confronting mice to the Unpredictable Chronic Mild Stress (UCMS) procedure-a validated model of stress-induced depression-results in behavioural alterations and biochemical changes in the kynurenine pathway (KP), suspected to modify ...
Anthony Laugeray, Jean-Marie Launay, Jacques Callebert, Oguz Mutlu, Gilles J Guillemin, Catherine Belzung, Pascal R Barone   +6 more
doaj   +1 more source

Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice

The Journal of Clinical Investigation, 2022
Neuropathic pain is one of the most important clinical consequences of injury to the somatosensory system. Nevertheless, the critical pathophysiological mechanisms involved in neuropathic pain development are poorly understood.
Alexandre G. Maganin, Guilherme R. Souza, Miriam D. Fonseca, Alexandre H. Lopes, Rafaela M. Guimarães, André Dagostin, Nerry T. Cecilio, Atlante S. Mendes, William A. Gonçalves, Conceição E.A. Silva, Francisco Isaac Fernandes Gomes, Lucas M. Mauriz Marques, Rangel L. Silva, Letícia M. Arruda, Denis A. Santana, Henrique Lemos, Lei Huang, Marcela Davoli-Ferreira, Danielle Santana-Coelho, Morena B. Sant’Anna, Ricardo Kusuda, Jhimmy Talbot, Gabriela Pacholczyk, Gabriela A. Buqui, Norberto P. Lopes, Jose C. Alves-Filho, Ricardo M. Leão, Jason C. O’Connor, Fernando Q. Cunha, Andrew Mellor, Thiago M. Cunha   +30 more
doaj   +1 more source

Divergent Inflammatory and Bioenergetic Metabolomic Signatures Distinguish Methamphetamine‐Associated From Idiopathic Pulmonary Arterial Hypertension

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Methamphetamine‐associated pulmonary arterial hypertension (Meth‐APAH) is an increasingly recognized cause of pulmonary arterial hypertension (PAH) and is associated with worse outcomes than idiopathic PAH (IPAH). Although both share histopathologic features of pulmonary vascular remodeling, the molecular basis for their clinical divergence ...
Hannah K. Robertson, Emma Yuguchi, Ian Gurholt, William C. Nichols, Nick H. Kim, Timothy Fernandes, Atul Malhotra, Mona Alotaibi   +7 more
wiley   +1 more source

Dysregulated Metabolism in People Living With HIV in the Modern ART‐Era: A Systematic Review of Targeted Metabolomics Studies

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT HIV remains a significant public health issue, with 1.3 million new infections and 630,000 deaths annually, and 40.8 million people living with HIV (PLHIV) globally in 2024. Although antiretroviral therapy (ART) suppresses viral replication, it does not eradicate the virus, and metabolic dysregulation persists despite treatment.
Levanco K. Asia, Du Toit Loots, Shayne Mason, Esme Jansen Van Vuren, Monray E. Williams   +4 more
wiley   +1 more source

Tryptophan Metabolism and Aryl‐Hydrocarbon Receptor Agonists in the Gut Microbiome of People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The gut microbiome of people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is investigated to identify changes in microbial tryptophan metabolism. We reveal a subcommunity of microbes that correlates with tryptophan metabolism that differs in structure and diversity and identify differences in stool indoles including aryl‐hydrocarbon
David J. Esteban, Brynn Conrad, Autumn Cullinan, Sharon Luong, Jason Albaum, Victoria Wilk   +5 more
wiley   +1 more source

Structure of a Product of a Fluorescence Reaction of 3-Hydroxykynurenine

Chemical and Pharmaceutical Bulletin, 1970
A product of fluorescence reaction of 3-hydroxykynurenine with p-toluenesulfonylchloride was separated and its structure was investigated. A reaction product of 2-amino-3-hydroxyacetophenone, which has the same configuration of carbonyl, amino and hydroxyl groups, with p-toluenesulfonylchloride was also studied.
WATANABE, MITSUO, TAMURA, ZENZO, OKADA, MASASHI   +2 more
openaire   +2 more sources