Results 61 to 70 of about 3,496 (164)

Tapinarof as a Therapeutic Aryl Hydrocarbon Receptor‐Modulating Agent in the Treatment of Atopic Dermatitis

The Journal of Dermatology, Volume 53, Issue 6, Page 867-879, June 2026.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory dermatitis underpinned by Type 2 inflammation driven by cytokines such as IL‐4 and IL‐13. It is characterized by skin barrier dysfunction, Th2 immune deviation, and pruritus. While biologics and oral Janus kinase (JAK) inhibitors demonstrate high therapeutic efficacy by targeting cytokines that ...
Gaku Tsuji, Yoko Fuyuno, Koji Kawamura, Ayako Yumine, Masaki Takemura, Yasutaka Mitamura, Kazuhiko Yamamura, Takeshi Nakahara   +7 more
wiley   +1 more source

Altitude‐Associated Divergence of the Gut Microbiome in Endangered Forest Musk Deer: Evidence From Integrated Metagenomics, Metabolomics, and Culturomics

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT High‐altitude environments expose mammals and their gut symbionts to multifaceted stressors—hypoxia, cold, and intense UV radiation. Whether gut microbial communities undergo compositional restructuring in response to these stressors, and whether such restructuring carries translational value for captive conservation, remain unresolved ...
Feiyun Huang, Zexiu Zhang, Yanni Zhao, Sen Ye, Maoyuan Gan, Xuxin Li, Yele Zhang, Lei Chen, Yushuo Zhang, Lingxi Chen, Ting Wang, Jinming Huang, Xiuyue Zhang   +12 more
wiley   +1 more source

Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect

Journal of Child Psychology and Psychiatry, Volume 67, Issue 6, Page 816-831, June 2026.
Background Mounting evidence links increased adiposity during pregnancy and offspring risk for mental health disorders. Yet the mechanisms underlying this association remain poorly understood, limiting our ability to design effective interventions.
Hanna C. Gustafsson, Hanna R. Wright, Jorden E. Jacinto Schreeder, Joel T. Nigg, Elinor L. Sullivan   +4 more
wiley   +1 more source

Sex‐Dependent Neurochemical Encoding of Acute Social Experience in Adult CD1 Mice

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
A brief social interaction triggers plasma corticosterone and brain neurochemistry changes in both male and female mice, even when their behaviour appears similar. Males primarily activate glutamate‐ and dopamine‐related pathways linked to motivation and reward, whereas females rely more on noradrenergic and serotonin‐related systems associated with ...
Garikoitz Azkona, Alina Díez‐Solinska, Oihane Saez‐Atxukarro, Luna Ochoteco‐Perales, Garikoitz Beitia‐Oyarzabal, Oscar Vegas   +5 more
wiley   +1 more source

A general mechanism of polypeptide cross-linking by 3-hydroxykynurenine

Redox Report, 1999
AbstractThe human lens contains a group of fluorescent compounds, derived from tryptophan, which act to absorb UV light in the 300–400 nm region of the spectrum.1 The major component is the glucoside of 3-hydroxykynurenine (3HK), 3-hydroxykynurenine glucoside (3HKG).2In the lens, 3HKG represents a unique pathway of tryptophan metabolism.
openaire   +2 more sources

Plasma‐Treated Water Induces Protein Oxidation in Mung Bean (Vigna radiata) and Chickpea (Cicer arietinum) Seedlings

Plasma Processes and Polymers, Volume 23, Issue 5, May 2026.
A schematic showing the plasma device producing RONS into water, PTW applied to chickpea and mung bean seedlings, and resulting effects: (1) increased root growth and (2) detection of specific oxidative protein markers using LC‐MS/MS. ABSTRACT Plasma‐treated water (PTW) is a promising sustainable agricultural resource, yet its effects on seedling ...
Mohammad Bayati, Brijesh K. Tiwari, Mahesha M. Poojary   +2 more
wiley   +1 more source

Fasting and Caloric Restriction Activate an ADIOL‐NHR‐91‐Kynurenine Pathway Signaling Axis to Promote Healthspan

Aging Cell, Volume 25, Issue 5, May 2026.
The steroid hormone ADIOL emerges as a key mediator of fasting–and caloric restriction–induced healthspan benefits in C. elegans. These regimens activate ADIOL production, which acts through the estrogen receptor β homolog NHR‐91 to reduce neural kynurenic acid levels and enhance healthspan independently of lifespan. ADIOL supplementation, even late in
Ana Guijarro‐Hernández, Shinja Yoo, George A. Lemieux, Sena Komatsu, Abdullah Q. Latiff, Rishika R. Patil, Kaveh Ashrafi   +6 more
wiley   +1 more source

Omega-3 fatty acid supplementation affects tryptophan metabolism during a 12-week endurance training in amateur runners: a randomized controlled trial

Scientific Reports
The effects of long-term omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation during endurance training on tryptophan (Trp) metabolism and mental state of healthy individuals have not been evaluated so far.
Maja Tomczyk, Monika Bidzan-Wiącek, Jakub Antoni Kortas, Magdalena Kochanowicz, Zbigniew Jost, Helena L. Fisk, Philip C. Calder, Jędrzej Antosiewicz   +7 more
doaj   +1 more source

Why Osteosarcopenia Matters: Clinical and Investigative Implications

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
Osteosarcopenia: Non‐pharmacological and pharmacological treatment strategies. ABSTRACT Background Osteosarcopenia, the combination of osteoporosis and sarcopenia, is a geriatric syndrome linked to functional decline, falls, and fragility fractures. The interaction among bone, muscle, and their shared pathophysiology is driven by mechanical, metabolic,
Erik Luiz Bonamigo, Marcella Nora Maia, Renata Pinheiro Cavallaro de Oliveira, Régis Gemerasca Mestriner, Ivan Aprahamian, Gustavo Duque   +5 more
wiley   +1 more source

Alterations in the Blood Kynurenine Pathway Following Long-Term PM2.5 and PM10 Exposure: A Cross-Sectional Study

Biomedicines
Human exposure to PM2.5 and PM10 has been linked to respiratory and cardiovascular diseases through inflammation activation. The kynurenine pathway is associated with inflammation, and it is necessary to investigate the effects of long-term PM2.5 and ...
Churdsak Jaikang, Giatgong Konguthaithip, Yutti Amornlertwatana, Narongchai Autsavapromporn, Sirichet Rattanachitthawat, Tawachai Monum   +5 more
doaj   +1 more source