Results 61 to 70 of about 5,521 (201)

Metabolic Profiling of Rumen Fluid and Milk in Lactating Dairy Cattle Influenced by Subclinical Ketosis Using Proton Nuclear Magnetic Resonance Spectroscopy

Animals, 2021
Ketosis metabolic research on lactating dairy cattle has been conducted worldwide; however, there have been very few Korean studies. Biofluids from lactating dairy cattle are necessary to study ketosis metabolic diseases.
Jun-Sik Eom, Hyun-Sang Kim, Shin-Ja Lee, You-Young Choi, Seong-Uk Jo, Jaemin Kim, Sang-Suk Lee, Eun-Tae Kim, Sung-Sill Lee   +8 more
doaj   +1 more source

Gestational kynurenine metabolites mediate effects of pregnancy adiposity on child negative affect

Journal of Child Psychology and Psychiatry, EarlyView.
Background Mounting evidence links increased adiposity during pregnancy and offspring risk for mental health disorders. Yet the mechanisms underlying this association remain poorly understood, limiting our ability to design effective interventions.
Hanna C. Gustafsson, Hanna R. Wright, Jorden E. Jacinto Schreeder, Joel T. Nigg, Elinor L. Sullivan   +4 more
wiley   +1 more source

Detoxification and stress response genes expressed in a western North American bumble bee, Bombus huntii (Hymenoptera: Apidae) [PDF]

, 2013
BACKGROUND: The Hunt bumble bee (Bombus huntii Greene, Hymenoptera: Apidae) is a holometabolous, social insect important as a pollinator in natural and agricultural ecosystems in western North America.
Dennis L Welker, James P Strange, Junhuan Xu, Rosalind R James   +3 more
core   +1 more source

The mediating role of the kynurenine pathway in longitudinal associations between dietary intake and quality of life in colorectal cancer survivors up to 12 months posttreatment

International Journal of Cancer, Volume 159, Issue 1, Page 122-143, 1 July 2026.
What's New? Many colorectal cancer survivors experience reduced health‐related quality of life (HRQoL), often lasting years after diagnosis. Healthy dietary patterns and even individual macro‐ and micronutrients, however, can potentially improve HRQoL.
Daniëlle D. B. Holthuijsen, Judith J. M. Rijnhart, Eline H. van Roekel, Martijn J. L. Bours, Per M. Ueland, Stéphanie O. Breukink, Maryska L. G. Janssen‐Heijnen, Joop L. Konsten, Eric T. P. Keulen, Adrian McCann, Stefanie Brezina, Biljana Gigic, Jennifer Ose, Matty P. Weijenberg, Simone J. P. M. Eussen   +14 more
wiley   +1 more source

Cellular Localization of Kynurenine 3-Monooxygenase in the Brain: Challenging the Dogma

Antioxidants, 2022
Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of tryptophan degradation, regulates the synthesis of the neuroactive metabolites 3-hydroxykynurenine (3-HK) and kynurenic acid (KYNA).
Korrapati V. Sathyasaikumar, Verónica Pérez de la Cruz, Benjamín Pineda, Gustavo Ignacio Vázquez Cervantes, Daniela Ramírez Ortega, David W. Donley, Paul L. Severson, Brian L. West, Flaviano Giorgini, Jonathan H. Fox, Robert Schwarcz   +10 more
doaj   +1 more source

Fasting and Caloric Restriction Activate an ADIOL‐NHR‐91‐Kynurenine Pathway Signaling Axis to Promote Healthspan

Aging Cell, Volume 25, Issue 5, May 2026.
The steroid hormone ADIOL emerges as a key mediator of fasting–and caloric restriction–induced healthspan benefits in C. elegans. These regimens activate ADIOL production, which acts through the estrogen receptor β homolog NHR‐91 to reduce neural kynurenic acid levels and enhance healthspan independently of lifespan. ADIOL supplementation, even late in
Ana Guijarro‐Hernández, Shinja Yoo, George A. Lemieux, Sena Komatsu, Abdullah Q. Latiff, Rishika R. Patil, Kaveh Ashrafi   +6 more
wiley   +1 more source

Role of lipid peroxidation in pathogenesis of senile cataract [PDF]

, 2009
Background /Aim. Cataract is a structural, biochemical and optical change in the eye lens, which changes transmission and refraction of light rays reducing keenness and clarity of a figure on the retina.
Dragojević Ilija, Kisić Bojana, Mirić Dijana, Stolić Aleksandra, Žorić Lepša   +4 more
core   +1 more source

Chronic Treatment with the IDO1 Inhibitor 1-Methyl-D-Tryptophan Minimizes the Behavioural and Biochemical Abnormalities Induced by Unpredictable Chronic Mild Stress in Mice - Comparison with Fluoxetine. [PDF]

PLoS ONE, 2016
We demonstrated that confronting mice to the Unpredictable Chronic Mild Stress (UCMS) procedure-a validated model of stress-induced depression-results in behavioural alterations and biochemical changes in the kynurenine pathway (KP), suspected to modify ...
Anthony Laugeray, Jean-Marie Launay, Jacques Callebert, Oguz Mutlu, Gilles J Guillemin, Catherine Belzung, Pascal R Barone   +6 more
doaj   +1 more source

Stage‐Dependent Changes in Kynurenine Pathway Enzyme Expression Suggest Immune‐Related Involvement in Bladder Cancer Progression

International Journal of Urology, Volume 33, Issue 5, May 2026.
ABSTRACT L‐tryptophan (Trp) metabolism through the L‐kynurenine (Kyn) pathway contributes to immune escape in neoplasms, including bladder cancer (BC). Indoleamine 2,3‐dioxygenase‐1 (IDO1) is a key enzyme, and its catabolites—Kyn, 3‐hydroxykynurenine (3HK), and 3‐hydroxyanthranilate (3HAA)—depend on other enzymes and play a crucial role in ...
Douglas Edgard Lemes, Aline Áurea de Souza Santos, Jéssica Lopes de Oliveira, Henrique Roman‐Ramos, Ana Carolina Ramos Moreno, Cleber Pinto Camacho, José Pontes‐Junior, Humberto Dellê   +7 more
wiley   +1 more source

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis [PDF]

, 2017
Recently, we reported a novel role for KMO in the pathogenesis of acute pancreatitis (AP). A number of inhibitors of kynurenine 3-monooxygenase (KMO) have previously been described as potential treatments for neurodegenerative conditions and particularly
Alexis Denis, Andrew McBride, Ann L. Walker, Anne Bouillot, Benjamin Beaufils, Carl P. Haslam, Christopher G. Mowat, Damian J. Mole, David Clapham, Duncan S. Holmes, Iain Uings, John Liddle, Jonathan P. Hutchinson, Lionel Trottet, Margaret Binnie, Marylise Bergeal, Nathalie Tiberghien, Nicolas Ancellin, Olivier Mirguet, Paul Rowland, Scott P. Webster, Xiaozhong Zheng   +21 more
core   +1 more source