Results 81 to 90 of about 5,596 (203)

Differential Analysis of IAA Anabolism Pathway Based on Bacillus cereus, Bacillus subtilis and Bacillus safensis Genome

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
Three Bacillus species isolated from Platycladus orientalis rhizosphere in Taihang Mountains: Bacillus cereus has 3 IAA synthesis pathways (TAM, IAM, IPyA); Bacillus subtilis has IAM/IPyA; and Bacillus safensis only has IPyA (via whole‐genome sequencing).
Dongyue Hou, Xuejie Zhai, Kezhong Zhang, Jinteng Cui   +3 more
wiley   +1 more source

Kynurenine pathway metabolism and the microbiota-gut-brain axis [PDF]

, 2018
It has become increasingly clear that the gut microbiota influences not only gastrointestinal physiology but also central nervous system (CNS) function by modulating signalling pathways of the microbiota-gut-brain axis.
Clarke, Gerard, Cryan, John F., Dinan, Timothy G., Kennedy, Paul J.   +3 more
core   +1 more source

Dynamic Factor Analysis for Sparse and Irregular Longitudinal Data: An Application to Metabolite Measurements in a COVID‐19 Study

Statistics in Medicine, Volume 45, Issue 6-7, March 2026.
ABSTRACT Factor analysis (FA) can be used to identify key biomarkers in biological processes by assuming that latent biological pathways (statistically, “latent factors”) drive the activity of measurable biomarkers (“observed variables”). However, biological pathways often interact, meaning that the classical FA assumption of independence between ...
Jiachen Cai, Robert J. B. Goudie, Brian D. M. Tom   +2 more
wiley   +1 more source

Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO [PDF]

, 2010
Innate responses combine with adaptive immunity to generate the most effective form of anti-Aspergillus immune resistance. Whereas the pivotal role of dendritic cells in determining the balance between immunopathology and protective immunity to the ...
A Carvalho, A Carvalho, A Curti, A de Luca, A de Luca, A Rivera, AK Mayer, B Guo, C Bretz, C D'Angelo, C Montagnoli, CH Geurtsvan Kessel, D Wesch, FL van de Veerdonk, H Liu, H Poeck, HS Suh, JA Wasylnka, JA Wasylnka, K de Smet, L Alekseeva, L Desvignes, L Romani, L Romani, L Romani, L Romani, LK Jasperson, LK Jasperson, M Mezger, N Meissner, NM Heller, O Gross, P Bonifazi, PY Bochud, Q Sha, RM Onishi, RP Schleimer, S Bellocchio, S Bellocchio, S Bozza, SC Gribar, SE Evans, SL Cassel, T Zelante, U Grohmann, V Balloy, W Chen, Z Jiang   +47 more
core   +1 more source

A pilot study of maternal vitamin D status and its association with breast milk and infant gut metabolites

Physiological Reports, Volume 14, Issue 5, March 2026.
Vitamin D status in our pilot study was associated with higher levels of certain amino acids and hexanoic acid in breast milk and metabolites in infant stool samples. Abstract Human milk contains multiple bioactive components, many of which are influenced by the mother's nutritional status.
Alyssa S. Gutierrez, Katherine E. Chetta, Santosh Thapa, Sigmund J. Haidacher, Kathleen M. Hoch, John E. Baatz, Anthony M. Haag, Numan Oezguen, Thomas D. Horvath, Carol L. Wagner, Melinda A. Engevik   +10 more
wiley   +1 more source

NAD+ Homeostasis Attenuates Japanese Encephalitis Virus Infection Progression

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
JEV infection in brain tissue triggers inflammation and stress in neuronal cells, leading to NAD+ depletion via the overactivation of PARPs and SIRTs. While compensatory biosynthetic pathways (de novo and salvage) were upregulated, the NAD+ level fell critically. In vitro NAMPT inhibition exacerbates this deficit and viral load.
Takele Adugna Kassegn, Zhancheng Tian, Junzheng Du, Qingli Niu, Jifei Yang, Zhang Hongge, Yuqing Song, Fengxue Chai, Zhonghui Zhang, Guiquan Guan, Hong Yin   +10 more
wiley   +1 more source

Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity. [PDF]

, 2014
Interferon γ (IFN-γ), an anticancer agent, is a strong inducer of indoleamine 2, 3-dioxygenase 1 (IDO1), which is a tryptophan-metabolizing enzyme involved in the induction of tumor immune tolerance.
Ando, M, Nishikawa, M, Saito, K, Takahashi, Y, Takakura, Y, Watanabe, Y, Watcharanurak, K, Yamamoto, Y, Yoshinaga, K, Zang, L   +9 more
core   +1 more source

Timing of NAD Deficiency During Organogenesis Dictates Defect Type and Penetrance

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
Pregnant mice on a vitamin B3‐free and tryptophan‐limited diet have embryos with Congenital NAD Deficiency Disorder, characterized by malformations and/or death. We longitudinally tracked the maternal NAD metabolome, embryo growth, and malformation occurrence. Mice with lower NAD Salvage Pathway metabolite levels and minimal levels of derived excretion
Kayleigh Bozon, Hartmut Cuny, Nana Sunn, Ella M. M. A. Martin, Delicia Z. Sheng, Gavin Chapman, Sally L. Dunwoodie   +6 more
wiley   +1 more source

Potential biomarkers of Parkinson’s disease revealed by plasma metabolic profiling [PDF]

, 2018
The plasma of Parkinson's disease (PD) patients may contain various altered metabolites associated with the risk or progression of the disease. Characterization of the abnormal metabolic pattern in PD plasma is therefore critical for the search for ...
Le, Weidong, Li, Wenxue, Liu, Xinxin, Wang, Cui, Yang, Zhaofei, Zhang, Xiaozhe, Zhao, Huiyuan, Zhao, Nan   +7 more
core   +1 more source

Integrated In Silico, In Vivo, and Deep Learning Approaches in the Discovery of Novel Candidate Molecules for Aedes aegypti Control

Archives of Insect Biochemistry and Physiology, Volume 121, Issue 2, February 2026.
An integrated computational/experimental workflow was used to identify new candidate molecules for Aedes aegypti control. Docking of 1,070 chalcones against mJHBP, followed by in vivo assays, identified 4′‐chloro‐4‐methoxychalcone (2c) as the most active larvicide candidate.
Herbert Bezerra Leite, Filipe Alves Ribeiro Rodrigues, Luana Beatriz Rocha Silva, Vanessa Costa Santos, Rosalvo F. Oliveira Neto, Edilson B. Alencar Filho   +5 more
wiley   +1 more source