Results 81 to 90 of about 3,496 (164)

Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia

Schizophrenia
Alterations in the kynurenine pathway of tryptophan metabolism have been implicated in the pathophysiology of schizophrenia. Here, we performed an in-depth analysis of all metabolites of the kynurenine pathway, i.e., tryptophan (TRY), kynurenic acid ...
Nico Antenucci, Giovanna D’Errico, Francesco Fazio, Ferdinando Nicoletti, Valeria Bruno, Giuseppe Battaglia   +5 more
doaj   +1 more source

Dietary advanced glycation products combined with chronic restraint stress induced anxiety-like and depression-like behaviors in male mice

npj Science of Food
Dietary advanced glycation end products (AGEs) and chronic stress might be involved in psychiatric disorders. It remains unclear whether dietary AGEs and chronic stress work together to trigger anxiety and depression.
Yebing Zhang, Kuiying Gu, Lili Xin, Yu Xia, Guoqi Yang, Jiejiao Cai, Zhilong He, Li-Qiang Qin, Zhongxiao Wan   +8 more
doaj   +1 more source

Diverse Physiological Roles of Kynurenine Pathway Metabolites: Updated Implications for Health and Disease

Metabolites
Tryptophan is an essential amino acid critical for human health. It plays a pivotal role in numerous physiological and biochemical processes through its metabolism.
Yuechang Wang, Yonggang Zhang, Wei Wang, Yanmin Zhang, Xueqian Dong, Yang Liu   +5 more
doaj   +1 more source

3-Hydroxykynurenine, a Tryptophan Metabolite Generated during the Infection, Is Active Against Trypanosoma cruzi. [PDF]

ACS Med Chem Lett, 2017
Knubel CP, Insfran C, Martinez FF, Diaz Lujan C, Fretes RE, Theumer MG, Cervi L, Motran CC.   +7 more
europepmc   +1 more source

Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis. [PDF]

Sci Rep, 2016
Skouras C, Zheng X, Binnie M, Homer NZ, Murray TB, Robertson D, Briody L, Paterson F, Spence H, Derr L, Hayes AJ, Tsoumanis A, Lyster D, Parks RW, Garden OJ, Iredale JP, Uings IJ, Liddle J, Wright WL, Dukes G, Webster SP, Mole DJ.   +21 more
europepmc   +1 more source

3-Hydroxykynurenine and 3-Hydroxyanthranilic Acid Enhance the Toxicity Induced by Copper in Rat Astrocyte Culture. [PDF]

Oxid Med Cell Longev, 2017
Ramírez-Ortega D, Ramiro-Salazar A, González-Esquivel D, Ríos C, Pineda B, Pérez de la Cruz V.   +5 more
europepmc   +1 more source

Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects. [PDF]

Neuroscience, 2017
Sathyasaikumar KV, Tararina M, Wu HQ, Neale SA, Weisz F, Salt TE, Schwarcz R.   +6 more
europepmc   +1 more source

Peritumoural adipose tissue promotes ferroptosis resistance by 3-hydroxykynurenine-mediated suppression of ferritinophagy. [PDF]

Nat Cell Biol
Zhang YY, Han Y, Tan YT, Lu YX, Ma MY, Zheng YQ, Chen HJ, Fu HY, Mo HY, Wu QN, Luo XJ, Liao K, Chen WQ, Zeng ZL, Piao HL, Du HL, Lin JZ, Tian T, Xu RH, Ju HQ.   +19 more
europepmc   +1 more source

Identification of Kynoxazine, a Novel Fluorescent Product of the Reaction between 3-Hydroxykynurenine and Erythrulose in the Human Lens, and Its Role in Protein Modification. [PDF]

J Biol Chem, 2016
Rakete S, Nagaraj RH.
europepmc   +1 more source

Tryptophan metabolites 3-hydroxykynurenine (3HK) and 3-hydroxyanthranilic acid (3HAA) increase oxidative stress and impair osteoblastic bone formation. [PDF]

J Biol Chem
Alhamad DW, Bensreti H, Ding K, Sultana S, Yearwood CL, Ellingwood A, Shaver J, Burkhart K, Tripathi A, Dorn J, Cushing M, Nesbit H, Dai C, Morey E, Gross C, Alhamad M, Taylor D, Cherezova A, Ilatovskaya DV, Zhi W, Cooley MA, Zhong R, Johnson MH, Bollag WB, Hamrick MW, Fulzele S, Hill WD, Isales CM, McGee-Lawrence ME.   +28 more
europepmc   +1 more source