Results 81 to 90 of about 5,521 (201)

Timing of NAD Deficiency During Organogenesis Dictates Defect Type and Penetrance

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
Pregnant mice on a vitamin B3‐free and tryptophan‐limited diet have embryos with Congenital NAD Deficiency Disorder, characterized by malformations and/or death. We longitudinally tracked the maternal NAD metabolome, embryo growth, and malformation occurrence. Mice with lower NAD Salvage Pathway metabolite levels and minimal levels of derived excretion
Kayleigh Bozon, Hartmut Cuny, Nana Sunn, Ella M. M. A. Martin, Delicia Z. Sheng, Gavin Chapman, Sally L. Dunwoodie   +6 more
wiley   +1 more source

Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO [PDF]

, 2010
Innate responses combine with adaptive immunity to generate the most effective form of anti-Aspergillus immune resistance. Whereas the pivotal role of dendritic cells in determining the balance between immunopathology and protective immunity to the ...
A Carvalho, A Carvalho, A Curti, A de Luca, A de Luca, A Rivera, AK Mayer, B Guo, C Bretz, C D'Angelo, C Montagnoli, CH Geurtsvan Kessel, D Wesch, FL van de Veerdonk, H Liu, H Poeck, HS Suh, JA Wasylnka, JA Wasylnka, K de Smet, L Alekseeva, L Desvignes, L Romani, L Romani, L Romani, L Romani, LK Jasperson, LK Jasperson, M Mezger, N Meissner, NM Heller, O Gross, P Bonifazi, PY Bochud, Q Sha, RM Onishi, RP Schleimer, S Bellocchio, S Bellocchio, S Bozza, SC Gribar, SE Evans, SL Cassel, T Zelante, U Grohmann, V Balloy, W Chen, Z Jiang   +47 more
core   +1 more source

Integrated In Silico, In Vivo, and Deep Learning Approaches in the Discovery of Novel Candidate Molecules for Aedes aegypti Control

Archives of Insect Biochemistry and Physiology, Volume 121, Issue 2, February 2026.
An integrated computational/experimental workflow was used to identify new candidate molecules for Aedes aegypti control. Docking of 1,070 chalcones against mJHBP, followed by in vivo assays, identified 4′‐chloro‐4‐methoxychalcone (2c) as the most active larvicide candidate.
Herbert Bezerra Leite, Filipe Alves Ribeiro Rodrigues, Luana Beatriz Rocha Silva, Vanessa Costa Santos, Rosalvo F. Oliveira Neto, Edilson B. Alencar Filho   +5 more
wiley   +1 more source

On the breeding habits of the Cowry Erronea errones (Linne) [PDF]

, 1954
Cowries are fairly common in the shallow a reas of Palk Bay and Gulf of Mannar. The species commonly found in the area between Mandapam Camp and Mandapam has been ide ntified as Erronea errones ...
Natarajan, A V
core  

Elevating Circulating L‐Kynurenine Promotes Frailty in Aging Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background L‐Kynurenine (L‐Kyn), a product of tryptophan catabolism, increases with age and has been associated with reduced physical function and increased frailty in humans. Robustly expressed in skeletal muscle, kynurenine aminotransferases (KATs) degrade L‐Kyn into kynurenic acid and are regulated by the transcriptional co‐regulator ...
Mia Y. Kawaida, Abigail L. Tice, Samuel Alvarez, Jacob A. Lackey, Benjamin Izaguirre, Qingping Yang, Lan Wei‐LaPierre, Russell T. Hepple, Terence E. Ryan   +8 more
wiley   +1 more source

Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity. [PDF]

, 2014
Interferon γ (IFN-γ), an anticancer agent, is a strong inducer of indoleamine 2, 3-dioxygenase 1 (IDO1), which is a tryptophan-metabolizing enzyme involved in the induction of tumor immune tolerance.
Ando, M, Nishikawa, M, Saito, K, Takahashi, Y, Takakura, Y, Watanabe, Y, Watcharanurak, K, Yamamoto, Y, Yoshinaga, K, Zang, L   +9 more
core   +1 more source

Transcriptomic, proteomic and biochemical comparison of luminescent and non‐luminescent Keroplatinae larvae (Diptera: Keroplatidae)

Insect Molecular Biology, Volume 35, Issue 1, Page 34-47, February 2026.
Transcriptomic and proteomic comparison of luminescent O. fultoni and non‐luminescent Neoditomyia sp show that the substrate binding fraction (SBF) has a similar abundance of hexamerins and the presence of flavin‐dependent reductases. In addition to the high content of keroplatin, SBF also contains considerable amounts of riboflavin and displays ...
Jaqueline R. Silva, Gabriel F. Pelentir, Danilo T. Amaral, Cassius Stevani, Vadim R. Viviani   +4 more
wiley   +1 more source

Antioxidative Efficacy of a Pistacia Lentiscus Supplement and Its Effect on the Plasma Amino Acid Profile in Inflammatory Bowel Disease: A Randomised, Double-Blind, Placebo-Controlled Trial [PDF]

, 2018
Oxidative stress is present in patients with Inflammatory Bowel Disease (IBD), and natural supplements with antioxidant properties have been investigated as a non-pharmacological approach. The objective of the present study was to assess the effects of a
Amerikanou, Charalampia, Forbes, Alastair, Kaliora, Andriana, Kalogeropoulos, Nick, Papada, Efstathia, Torović, Ljilja, Triantafillidis, John, Tzavara, Chara   +7 more
core   +1 more source

Omega-3 fatty acid supplementation affects tryptophan metabolism during a 12-week endurance training in amateur runners: a randomized controlled trial

Scientific Reports
The effects of long-term omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation during endurance training on tryptophan (Trp) metabolism and mental state of healthy individuals have not been evaluated so far.
Maja Tomczyk, Monika Bidzan-Wiącek, Jakub Antoni Kortas, Magdalena Kochanowicz, Zbigniew Jost, Helena L. Fisk, Philip C. Calder, Jędrzej Antosiewicz   +7 more
doaj   +1 more source

Association Between the Dutch Mediterranean‐Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND‐NL) Diet Adherence and Systemic Tryptophan Metabolites in Older Adults at Risk of Cognitive Decline: An Exploratory Study

Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
Following the MIND diet may support brain health in older adults at risk of cognitive decline by influencing tryptophan (TRP) metabolism. Plasma samples and dietary intake data from the HELI intervention trial were used. Bivariate latent change score modeling analysis showed that greater adherence to the MIND diet was linked to higher tryptophan levels,
Sonja Beers, Lisette C. P. G. M. de Groot, Mark R. van Loenen, Lianne B. Remie, Mechteld Grootte Bromhaar, Andrea Anesi, Urska Vrhovsek, Joukje M. Oosterman, Esther Aarts, Mara P. H. van Trijp, Yannick Vermeiren   +10 more
wiley   +1 more source