Results 101 to 110 of about 5,521 (201)

Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition

Frontiers in Molecular Biosciences, 2019
The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid ...
Robert S. Phillips, Robert S. Phillips, Emma Carine Iradukunda, Tamera Hughes, J. Phillip Bowen   +4 more
doaj   +1 more source

Inhibition of 3-Hydroxykynurenine Transaminase from Aedes aegypti and Anopheles gambiae: A Mosquito-Specific Target to Combat the Transmission of Arboviruses. [PDF]

ACS Bio Med Chem Au, 2023
Maciel LG, Ferraz MVF, Oliveira AA, Lins RD, Dos Anjos JV, Guido RVC, Soares TA.   +6 more
europepmc   +1 more source

Oxidative stress in bacteria and protein damage by reactive oxygen species [PDF]

, 2010
The advent of O2 in the atmosphere was among the first major pollution events occurred on earth The reaction between ferrous iron, very abundant in the reductive early atmosphere, and oxygen results in the formation of harmful superoxide and hydroxyl ...
Elisa Cabiscol, Joaquim Ros, Jordi Tamarit   +2 more
core   +2 more sources

A prospective evaluation of serum kynurenine metabolites and risk of pancreatic cancer.

PLoS ONE, 2018
BackgroundSerum pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, is associated with reduced risk of pancreatic cancer. Data on functional measures of vitamin B6 status and risk of pancreatic cancer is lacking.MethodsA nested case-control ...
Joyce Y Huang, Lesley M Butler, Øivind Midttun, Arve Ulvik, Renwei Wang, Aizhen Jin, Yu-Tang Gao, Per M Ueland, Woon-Puay Koh, Jian-Min Yuan   +9 more
doaj   +1 more source

A second generation of 1,2,4-oxadiazole derivatives with enhanced solubility for inhibition of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti. [PDF]

RSC Med Chem, 2021
Maciel LG, Barbosa ADS, de Alencar-Filho EB, Soares TA, Dos Anjos JV.   +4 more
europepmc   +1 more source

Postoperative Serum Quinolinic Acid and 3-Hydroxykynurenine in Dogs with Congenital Portosystemic Shunt: A Pilot Study of Their Association with Postattenuation Neurologic Signs

Veterinary Sciences
Postattenuation neurologic signs (PANS) are serious complications following surgical ligation of congenital portosystemic shunts (cPSS) in dogs, but their pathogenesis remains incompletely understood. We hypothesized that surgical ligation alters hepatic
Shoma Mikawa, Yuto Ishimaru, Yasuhiko Okamura   +2 more
doaj   +1 more source

The Synthesis of 3-Hydroxykynurenine (+Chromogen) [PDF]

Bulletin of the Chemical Society of Japan, 1950
Yoshimasa Hirata, Koji Nakanishi
openaire   +1 more source

Aryl hydrocarbon receptor activation mediates kidney disease and renal cell carcinoma. [PDF]

, 2019
The aryl hydrocarbon receptor (AhR) is a well-known ligand-activated cytoplasmic transcription factor that contributes to cellular responses against environmental toxins and carcinogens.
Chen, Lin, Feng, Ya-Long, Guo, Yan, Liu, Bao-Li, Liu, Qing-Quan, Vaziri, Nosratola D, Yang, Tian, Zhao, Hui, Zhao, Ying-Yong   +8 more
core   +1 more source

Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery.

PLoS ONE, 2018
ObjectiveObesity is associated with increased inflammation and insulin resistance. In conditions with chronic immune activation, low plasma vitamin B6-levels are described, as well as an increased kynurenine:tryptophan-ratio (KTR).
Monika H E Christensen, Dag J Fadnes, Therese H Røst, Eva R Pedersen, John R Andersen, Villy Våge, Arve Ulvik, Øivind Midttun, Per M Ueland, Ottar K Nygård, Gunnar Mellgren   +10 more
doaj   +1 more source

Sex differences in peripheral and central dysregulation of the kynurenine pathway in Parkinson’s disease

npj Parkinson's Disease
We previously demonstrated that kynurenine pathway (KP) dysregulation associates with Parkinson’s disease (PD) and its symptoms. Here, we profiled 16 KP-related markers in a second, independent cohort; plasma: n = 202 (116 PD (“OFF”), 86 controls); CSF ...
Leslie C. Jellen, Martha L. Escobar Galvis, Qiong Sha, Christine Isaguirre, Amy Johnson, Zach Madaj, Mechelle M. Lewis, Ryan D. Sheldon, Lan Kong, Xuemei Huang, Lena Brundin   +10 more
doaj   +1 more source