Increased Indoleamine-2,3-Dioxygenase Activity Is Associated With Poor Clinical Outcome in Adults Hospitalized With Influenza in the INSIGHT FLU003Plus Study [PDF]
, 2018 BACKGROUND: Indoleamine-2,3-dioxygenase (IDO) mediated tryptophan (TRP) depletion has antimicrobial and immuno-regulatory effects. Increased kynurenine (KYN)-to-TRP (KT) ratios, reflecting increased IDO activity, have been associated with poorer outcomes
Davey, RT +12 more
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Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity [PDF]
, 2017 We report a systematic RNAi longevity screen of 82 Caenorhabditis elegans genes selected based on orthology to human genes differentially expressed with age. We find substantial enrichment in genes for which knockdown increased lifespan.
Backer, G. (Grant) +10 more
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Frontiers in Aging Neuroscience, 2018 Down syndrome (DS), caused by trisomy of chromosome 21, is the most common genetic cause of intellectual disability. Individuals with DS exhibit changes in neurochemistry and neuroanatomy that worsen with age, neurological delay in learning and memory ...
Nathan Duval +2 more
doaj +1 more source
The excretion of kynurenine and 3-hydroxykynurenine by man [PDF]
Biochemical Journal, 1954 C E, DALGLIESH, S, TEKMAN
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Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition
Frontiers in Molecular Biosciences, 2019 The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid ...
Robert S. Phillips +4 more
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Oxidative stress in bacteria and protein damage by reactive oxygen species [PDF]
, 2010 The advent of O2 in the atmosphere was among the first major pollution events occurred on earth The reaction between ferrous iron, very abundant in the reductive early atmosphere, and oxygen results in the formation of harmful superoxide and hydroxyl ...
Elisa Cabiscol +2 more
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Inhibition of 3-Hydroxykynurenine Transaminase from Aedes aegypti and Anopheles gambiae: A Mosquito-Specific Target to Combat the Transmission of Arboviruses. [PDF]
ACS Bio Med Chem Au, 2023 Maciel LG +6 more
europepmc +1 more source
Aryl hydrocarbon receptor activation mediates kidney disease and renal cell carcinoma. [PDF]
, 2019 The aryl hydrocarbon receptor (AhR) is a well-known ligand-activated cytoplasmic transcription factor that contributes to cellular responses against environmental toxins and carcinogens.
Chen, Lin +8 more
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A second generation of 1,2,4-oxadiazole derivatives with enhanced solubility for inhibition of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti. [PDF]
RSC Med Chem, 2021 Maciel LG +4 more
europepmc +1 more source
The Synthesis of 3-Hydroxykynurenine (+Chromogen) [PDF]
Bulletin of the Chemical Society of Japan, 1950 Yoshimasa Hirata, Koji Nakanishi
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