Results 111 to 120 of about 5,596 (203)

Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery.

PLoS ONE, 2018
ObjectiveObesity is associated with increased inflammation and insulin resistance. In conditions with chronic immune activation, low plasma vitamin B6-levels are described, as well as an increased kynurenine:tryptophan-ratio (KTR).
Monika H E Christensen, Dag J Fadnes, Therese H Røst, Eva R Pedersen, John R Andersen, Villy Våge, Arve Ulvik, Øivind Midttun, Per M Ueland, Ottar K Nygård, Gunnar Mellgren   +10 more
doaj   +1 more source

Neurotoxic effects of citronellol induced by the conversion of kynurenine to 3-hydroxykynurenine

Journal of Hazardous Materials
Citronellol is widely utilized in consumer products, including cosmetics, fragrances, and household items. However, despite being considered a relatively safe chemical, the health effects and toxicity mechanisms associated with exposure to high concentrations of citronellol, based on product content, remain inadequately understood.
Seong Soon Kim, Suhyun Kim, Yeonhwa Kim, Youngran Ha, Hyojin Lee, Hyunji Im, Jung Yoon Yang, Dae-Seop Shin, Kyu-Seok Hwang, Yuji Son, Sung Bum Park, Ki Young Kim, Han-Seul Lee, Ki-Tae Kim, Sung-Hee Cho, Myung Ae Bae, Hae-Chul Park   +16 more
openaire   +2 more sources

Sex differences in peripheral and central dysregulation of the kynurenine pathway in Parkinson’s disease

npj Parkinson's Disease
We previously demonstrated that kynurenine pathway (KP) dysregulation associates with Parkinson’s disease (PD) and its symptoms. Here, we profiled 16 KP-related markers in a second, independent cohort; plasma: n = 202 (116 PD (“OFF”), 86 controls); CSF ...
Leslie C. Jellen, Martha L. Escobar Galvis, Qiong Sha, Christine Isaguirre, Amy Johnson, Zach Madaj, Mechelle M. Lewis, Ryan D. Sheldon, Lan Kong, Xuemei Huang, Lena Brundin   +10 more
doaj   +1 more source

Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia

Schizophrenia
Alterations in the kynurenine pathway of tryptophan metabolism have been implicated in the pathophysiology of schizophrenia. Here, we performed an in-depth analysis of all metabolites of the kynurenine pathway, i.e., tryptophan (TRY), kynurenic acid ...
Nico Antenucci, Giovanna D’Errico, Francesco Fazio, Ferdinando Nicoletti, Valeria Bruno, Giuseppe Battaglia   +5 more
doaj   +1 more source

Diverse Physiological Roles of Kynurenine Pathway Metabolites: Updated Implications for Health and Disease

Metabolites
Tryptophan is an essential amino acid critical for human health. It plays a pivotal role in numerous physiological and biochemical processes through its metabolism.
Yuechang Wang, Yonggang Zhang, Wei Wang, Yanmin Zhang, Xueqian Dong, Yang Liu   +5 more
doaj   +1 more source

Expression analysis of novel striatal-enriched genes in Huntington disease [PDF]

, 2017
Selective degeneration of striatal neurons is a pathologic hallmark of Huntington disease (HD). The exact mechanism(s) behind this specific neurodegeneration is still unknown.
Becanovic, Kristina, Leavitt, Blair R., Luthi-Carter, Ruth, Mazarei, Gelareh, Neal, Scott J., Simpson, Elizabeth M.   +5 more
core  

Dietary advanced glycation products combined with chronic restraint stress induced anxiety-like and depression-like behaviors in male mice

npj Science of Food
Dietary advanced glycation end products (AGEs) and chronic stress might be involved in psychiatric disorders. It remains unclear whether dietary AGEs and chronic stress work together to trigger anxiety and depression.
Yebing Zhang, Kuiying Gu, Lili Xin, Yu Xia, Guoqi Yang, Jiejiao Cai, Zhilong He, Li-Qiang Qin, Zhongxiao Wan   +8 more
doaj   +1 more source

The effect of dietary tryptophan levels on oxidative stress of liver induced by diquat in weaned piglets [PDF]

, 2014

core   +1 more source

3-Hydroxykynurenine, a Tryptophan Metabolite Generated during the Infection, Is Active Against Trypanosoma cruzi. [PDF]

ACS Med Chem Lett, 2017
Knubel CP, Insfran C, Martinez FF, Diaz Lujan C, Fretes RE, Theumer MG, Cervi L, Motran CC.   +7 more
europepmc   +1 more source

Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis. [PDF]

Sci Rep, 2016
Skouras C, Zheng X, Binnie M, Homer NZ, Murray TB, Robertson D, Briody L, Paterson F, Spence H, Derr L, Hayes AJ, Tsoumanis A, Lyster D, Parks RW, Garden OJ, Iredale JP, Uings IJ, Liddle J, Wright WL, Dukes G, Webster SP, Mole DJ.   +21 more
europepmc   +1 more source