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The role of oral contraceptive use in associations of concussion history with kynurenine pathway metabolites, inflammation, and psychological symptoms in female athletes. [PDF]
Brain Behav Immun HealthGoeckner BD +5 more
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Serum Kynurenine Pathway Metabolites as Candidate Diagnostic Biomarkers for Pituitary Adenoma: A Case-Control Study. [PDF]
Medicina (Kaunas)Oflas ND, Akbay Hİ, Alay M, Erdem M.
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3-Hydroxykynurenine as a substrate/activator for mushroom tyrosinase
Archives of Biochemistry and Biophysics, 20033-Hydroxykynurenine is a tryptophan metabolite with an o-aminophenol structure. It is both a tyrosinase activator and a substrate, reducing the lag phase, stimulating the monophenolase activity, and being oxidized to xanthommatin. In the early stage of monophenol hydroxylation, catechol accumulation takes place, whereas 3-hydroxykynurenine is ...
Antonio Rescigno +2 more
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Increased brain concentrations of a neurotoxin, 3-hydroxykynurenine, in Huntington's disease
Neuroscience Letters, 1992Concentrations of the neurotoxic tryptophan metabolite, 3-hydroxykynurenine, were determined in brain tissue taken post-mortem from patients with Huntington's disease and Alzheimer's disease. 3-Hydroxykynurenine was substantially and significantly increased in all three brain areas studied in Huntington's disease, but not significantly increased in the
G P Reynolds, S J Pearson, G P Reynolds
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3‐Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum
European Journal of Neuroscience, 1999Abstractl‐3‐Hydroxykynurenine (L‐3‐HK) and quinolinate (QUIN) are two metabolites of the kynurenine pathway, the major route of tryptophan degradation in mammals. L‐3‐HK is a known generator of highly reactive free radicals, whereas QUIN is an endogenous excitotoxin acting specifically at N‐methyl‐d‐aspartate (NMDA) receptors.
Robert Schwarcz, P Guidetti
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Oxidation of 3‐hydroxykynurenine. A reexamination
Journal of Heterocyclic Chemistry, 1988AbstractThe oxidation mixture of 3‐hydroxykynurenine (1), treated with aqueous acetic anhydride and, subsequently, with acidic methanol, yields the 1‐hydroxy‐3‐carbomethoxy‐5‐methoxy‐11‐(β‐aspartoyl‐N‐acetyl‐methyl ester)pyrido[3,2‐a]phenoxazine (5), the 1‐hydroxy‐11‐(β‐aspartoyl‐N‐acetyl‐methyl ester)‐5.H‐pyrido[3,2‐a]‐phenoxazin‐5‐one (6), the 1 ...
A. Bolognese +3 more
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