Results 91 to 100 of about 5,596 (203)

Omega-3 fatty acid supplementation affects tryptophan metabolism during a 12-week endurance training in amateur runners: a randomized controlled trial

Scientific Reports
The effects of long-term omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation during endurance training on tryptophan (Trp) metabolism and mental state of healthy individuals have not been evaluated so far.
Maja Tomczyk, Monika Bidzan-Wiącek, Jakub Antoni Kortas, Magdalena Kochanowicz, Zbigniew Jost, Helena L. Fisk, Philip C. Calder, Jędrzej Antosiewicz   +7 more
doaj   +1 more source

The spectral transmission of ocular media suggests ultraviolet sensitivity is widespread among mammals [PDF]

, 2014
Although ultraviolet (UV) sensitivity is widespread among animals it is considered rare in mammals, being restricted to the few species that have a visual pigment maximally sensitive (λmax) below 400 nm.
Algvere PV, Brainard GC, Brainard GC, Collier R, Gaillard ER, Hunt S, Jacobs GH, Maddock SA, Trokel S, Van Heyningen R, Van Norren D, Xuan FJ, Zigman S   +12 more
core   +1 more source

Elevating Circulating L‐Kynurenine Promotes Frailty in Aging Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background L‐Kynurenine (L‐Kyn), a product of tryptophan catabolism, increases with age and has been associated with reduced physical function and increased frailty in humans. Robustly expressed in skeletal muscle, kynurenine aminotransferases (KATs) degrade L‐Kyn into kynurenic acid and are regulated by the transcriptional co‐regulator ...
Mia Y. Kawaida, Abigail L. Tice, Samuel Alvarez, Jacob A. Lackey, Benjamin Izaguirre, Qingping Yang, Lan Wei‐LaPierre, Russell T. Hepple, Terence E. Ryan   +8 more
wiley   +1 more source

Alterations in the Blood Kynurenine Pathway Following Long-Term PM2.5 and PM10 Exposure: A Cross-Sectional Study

Biomedicines
Human exposure to PM2.5 and PM10 has been linked to respiratory and cardiovascular diseases through inflammation activation. The kynurenine pathway is associated with inflammation, and it is necessary to investigate the effects of long-term PM2.5 and ...
Churdsak Jaikang, Giatgong Konguthaithip, Yutti Amornlertwatana, Narongchai Autsavapromporn, Sirichet Rattanachitthawat, Tawachai Monum   +5 more
doaj   +1 more source

Antioxidative Efficacy of a Pistacia Lentiscus Supplement and Its Effect on the Plasma Amino Acid Profile in Inflammatory Bowel Disease: A Randomised, Double-Blind, Placebo-Controlled Trial [PDF]

, 2018
Oxidative stress is present in patients with Inflammatory Bowel Disease (IBD), and natural supplements with antioxidant properties have been investigated as a non-pharmacological approach. The objective of the present study was to assess the effects of a
Amerikanou, Charalampia, Forbes, Alastair, Kaliora, Andriana, Kalogeropoulos, Nick, Papada, Efstathia, Torović, Ljilja, Triantafillidis, John, Tzavara, Chara   +7 more
core   +1 more source

A general mechanism of polypeptide cross-linking by 3-hydroxykynurenine

Redox Report, 1999
AbstractThe human lens contains a group of fluorescent compounds, derived from tryptophan, which act to absorb UV light in the 300–400 nm region of the spectrum.1 The major component is the glucoside of 3-hydroxykynurenine (3HK), 3-hydroxykynurenine glucoside (3HKG).2In the lens, 3HKG represents a unique pathway of tryptophan metabolism.
openaire   +2 more sources

Transcriptomic, proteomic and biochemical comparison of luminescent and non‐luminescent Keroplatinae larvae (Diptera: Keroplatidae)

Insect Molecular Biology, Volume 35, Issue 1, Page 34-47, February 2026.
Transcriptomic and proteomic comparison of luminescent O. fultoni and non‐luminescent Neoditomyia sp show that the substrate binding fraction (SBF) has a similar abundance of hexamerins and the presence of flavin‐dependent reductases. In addition to the high content of keroplatin, SBF also contains considerable amounts of riboflavin and displays ...
Jaqueline R. Silva, Gabriel F. Pelentir, Danilo T. Amaral, Cassius Stevani, Vadim R. Viviani   +4 more
wiley   +1 more source

M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus [PDF]

, 2016
Monoamine oxidases (MAO), downstream targets of glucocorticoid, maintain the turnover and homeostasis of monoamine neurotransmitters; yet, its pathophysiological role in monoamine deficiency, oxidative stress and neuroinflammation remains controversial ...
Fung, ML, LAM, CS, Tipoe, GL, Wong, KC, Youdim, MBH   +4 more
core   +1 more source

Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice [PDF]

, 2015
L-Kynurenine (L-KYN) is a central metabolite of tryptophan degradation through the kynurenine pathway (KP). The systemic administration of L-KYN sulfate (L-KYNs) leads to a rapid elevation of the neuroactive KP metabolite kynurenic acid (KYNA).
Dániel Varga, Etsuro Ono, Hiroki Takakuwa, Judit Herédi, József Toldi, Levente Gellért, László Vécsei, Marian Ruszka, Naoki Iwamori, Tokuko Iwamori, Zita Kánvási, Zsolt Kis   +11 more
core   +1 more source

Distinct effects of fish oil and olive oil on neurotransmitter metabolism, gut microbiota, and gut–brain axis dysfunction, depression-like behaviors in CUMS-induced rats

Journal of Agriculture and Food Research
The pathogenesis of depression involves both physiological and psychological factors. Through the gut-brain axis, neurotransmitters, gut barrier function, and microbiota jointly regulate neuroinflammation, influencing brain function and emotional ...
Pin-Yu Chiang, Chen-Yu Liao, Chin-Ying Wu, Wei-Yu Kao, Yi-Tung Lin, Pin-Hui Wei, Te-Hsuan Tung, Shih-Yi Huang   +7 more
doaj   +1 more source