Results 91 to 100 of about 5,521 (201)

The spectral transmission of ocular media suggests ultraviolet sensitivity is widespread among mammals [PDF]

, 2014
Although ultraviolet (UV) sensitivity is widespread among animals it is considered rare in mammals, being restricted to the few species that have a visual pigment maximally sensitive (λmax) below 400 nm.
Algvere PV, Brainard GC, Brainard GC, Collier R, Gaillard ER, Hunt S, Jacobs GH, Maddock SA, Trokel S, Van Heyningen R, Van Norren D, Xuan FJ, Zigman S   +12 more
core   +1 more source

Alterations in the Blood Kynurenine Pathway Following Long-Term PM2.5 and PM10 Exposure: A Cross-Sectional Study

Biomedicines
Human exposure to PM2.5 and PM10 has been linked to respiratory and cardiovascular diseases through inflammation activation. The kynurenine pathway is associated with inflammation, and it is necessary to investigate the effects of long-term PM2.5 and ...
Churdsak Jaikang, Giatgong Konguthaithip, Yutti Amornlertwatana, Narongchai Autsavapromporn, Sirichet Rattanachitthawat, Tawachai Monum   +5 more
doaj   +1 more source

Disruption of Gut Microbiota‐Mediated De Novo NAD+ Synthesis Contributes to the Development of Polycystic Ovary Syndrome

Advanced Science, Volume 12, Issue 45, December 4, 2025.
This study demonstrates that patients with PCOS exhibit altered gut microbial profiles, and FMT from PCOS patients induces PCOS‐like symptoms in mice. Specifically, gut dysbiosis reduces 3‐HAA levels in the context of PCOS. Administration of 3‐HAA to mice alleviates PCOS by promoting de novo NAD+ synthesis.
Ke Chen, Huafeng Geng, Yang Zheng, Hongyang Xie, Rui Qin, Junyang Chen, Cong Ye   +6 more
wiley   +1 more source

M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus [PDF]

, 2016
Monoamine oxidases (MAO), downstream targets of glucocorticoid, maintain the turnover and homeostasis of monoamine neurotransmitters; yet, its pathophysiological role in monoamine deficiency, oxidative stress and neuroinflammation remains controversial ...
Fung, ML, LAM, CS, Tipoe, GL, Wong, KC, Youdim, MBH   +4 more
core   +1 more source

Interoception and inflammation in psychiatric disorders [PDF]

, 2018
Despite a historical focus on neurally-mediated interoceptive signaling mechanisms, humoral (and even cellular) signals also play an important role in communicating bodily physiological state to the brain.
Aaronson, Airaksinen, Baglioni, Ban, Banks, Barrett, Baumeister, Baune, Bilbo, Bluthe, Brevet, Brydon, Bunzeck, Campbell, Capuron, Capuron, Capuron, Cho, Chrovian, Cohen, Craig, Critchley, Dantzer, Dantzer, Dorr, Dowell, Dowell, Eisenberger, Ek, Ericsson, Estes, Evans, Ewing, Felger, Felger, Felger, Fotuhi, Goehler, Goehler, Goldsmith, Goldsmith, Gorwood, Graybiel, Gross, Haapakoski, Hannestad, Harden, Haroon, Haroon, Harrison, Harrison, Harrison, Harrison, Harrison, Harrison, Harshaw, Hart, Hawrylycz, Hollerman, Hornig, Irwin, Irwin, Irwin, Irwin, Iwashyna, Jansen, Kamata, Kelley, Kitagami, Kohler, Koopman, Krishnadas, Krueger, Krueger, Laflamme, Lebon, Lee, Lee, Lekander, Marsland, Martinot, Meier, Meyer, Miller, Moller, Montagne, Mostafavi, Netea, Nimmerjahn, Pacheco-Lopez, Palminteri, Pang, Paolicelli, Paulus, Perry, Pessiglione, Prinz, Puntener, Raison, Raison, Raison, Raison, Raz, Reichenberg, Richetto, Rivest, Rosenkranz, Saito, Sandiego, Saper, Satizabal, Savitz, Savitz, Savitz, Schafer, Schultz, Schulz, Seth, Setiawan, Sharpley, Shuto, Smith, Stephan, Suzuki, Sweeney, Torrey, Tracey, Tyring, van den Biggelaar, van Kesteren, Videbech, Wan, Wang, Wang, Weaver, Weber, Werner, Wohleb, Wohleb, Wohleb, Wurfel, Yirmiya, Young, Zielinski, Zung   +144 more
core   +1 more source

Distinct effects of fish oil and olive oil on neurotransmitter metabolism, gut microbiota, and gut–brain axis dysfunction, depression-like behaviors in CUMS-induced rats

Journal of Agriculture and Food Research
The pathogenesis of depression involves both physiological and psychological factors. Through the gut-brain axis, neurotransmitters, gut barrier function, and microbiota jointly regulate neuroinflammation, influencing brain function and emotional ...
Pin-Yu Chiang, Chen-Yu Liao, Chin-Ying Wu, Wei-Yu Kao, Yi-Tung Lin, Pin-Hui Wei, Te-Hsuan Tung, Shih-Yi Huang   +7 more
doaj   +1 more source

A general mechanism of polypeptide cross-linking by 3-hydroxykynurenine

Redox Report, 1999
AbstractThe human lens contains a group of fluorescent compounds, derived from tryptophan, which act to absorb UV light in the 300–400 nm region of the spectrum.1 The major component is the glucoside of 3-hydroxykynurenine (3HK), 3-hydroxykynurenine glucoside (3HKG).2In the lens, 3HKG represents a unique pathway of tryptophan metabolism.
openaire   +2 more sources

Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice [PDF]

, 2015
L-Kynurenine (L-KYN) is a central metabolite of tryptophan degradation through the kynurenine pathway (KP). The systemic administration of L-KYN sulfate (L-KYNs) leads to a rapid elevation of the neuroactive KP metabolite kynurenic acid (KYNA).
Dániel Varga, Etsuro Ono, Hiroki Takakuwa, Judit Herédi, József Toldi, Levente Gellért, László Vécsei, Marian Ruszka, Naoki Iwamori, Tokuko Iwamori, Zita Kánvási, Zsolt Kis   +11 more
core   +1 more source

Rapamycin Treatment Ameliorates Age-Related Accumulation of Toxic Metabolic Intermediates in Brains of the Ts65Dn Mouse Model of Down Syndrome and Aging

Frontiers in Aging Neuroscience, 2018
Down syndrome (DS), caused by trisomy of chromosome 21, is the most common genetic cause of intellectual disability. Individuals with DS exhibit changes in neurochemistry and neuroanatomy that worsen with age, neurological delay in learning and memory ...
Nathan Duval, Guido N. Vacano, David Patterson   +2 more
doaj   +1 more source

Increased Indoleamine-2,3-Dioxygenase Activity Is Associated With Poor Clinical Outcome in Adults Hospitalized With Influenza in the INSIGHT FLU003Plus Study [PDF]

, 2018
BACKGROUND: Indoleamine-2,3-dioxygenase (IDO) mediated tryptophan (TRP) depletion has antimicrobial and immuno-regulatory effects. Increased kynurenine (KYN)-to-TRP (KT) ratios, reflecting increased IDO activity, have been associated with poorer outcomes
Davey, RT, Dwyer, D, Griffin, TJ, Hodgson, SW, INSIGHT FLU003 Plus Study Group, ., Kalomenidis, I, Kunisaki, KM, Montejano Sanchez, R, Nahra, R, Pett, SL, Ruxrungtham, K, Wendt, CH, Wentworth, D   +12 more
core