Results 71 to 80 of about 5,596 (203)

Fasting and Caloric Restriction Activate an ADIOL‐NHR‐91‐Kynurenine Pathway Signaling Axis to Promote Healthspan

Aging Cell, Volume 25, Issue 5, May 2026.
The steroid hormone ADIOL emerges as a key mediator of fasting–and caloric restriction–induced healthspan benefits in C. elegans. These regimens activate ADIOL production, which acts through the estrogen receptor β homolog NHR‐91 to reduce neural kynurenic acid levels and enhance healthspan independently of lifespan. ADIOL supplementation, even late in
Ana Guijarro‐Hernández, Shinja Yoo, George A. Lemieux, Sena Komatsu, Abdullah Q. Latiff, Rishika R. Patil, Kaveh Ashrafi   +6 more
wiley   +1 more source

Chronic Treatment with the IDO1 Inhibitor 1-Methyl-D-Tryptophan Minimizes the Behavioural and Biochemical Abnormalities Induced by Unpredictable Chronic Mild Stress in Mice - Comparison with Fluoxetine. [PDF]

PLoS ONE, 2016
We demonstrated that confronting mice to the Unpredictable Chronic Mild Stress (UCMS) procedure-a validated model of stress-induced depression-results in behavioural alterations and biochemical changes in the kynurenine pathway (KP), suspected to modify ...
Anthony Laugeray, Jean-Marie Launay, Jacques Callebert, Oguz Mutlu, Gilles J Guillemin, Catherine Belzung, Pascal R Barone   +6 more
doaj   +1 more source

Why Osteosarcopenia Matters: Clinical and Investigative Implications

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
Osteosarcopenia: Non‐pharmacological and pharmacological treatment strategies. ABSTRACT Background Osteosarcopenia, the combination of osteoporosis and sarcopenia, is a geriatric syndrome linked to functional decline, falls, and fragility fractures. The interaction among bone, muscle, and their shared pathophysiology is driven by mechanical, metabolic,
Erik Luiz Bonamigo, Marcella Nora Maia, Renata Pinheiro Cavallaro de Oliveira, Régis Gemerasca Mestriner, Ivan Aprahamian, Gustavo Duque   +5 more
wiley   +1 more source

Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice

The Journal of Clinical Investigation, 2022
Neuropathic pain is one of the most important clinical consequences of injury to the somatosensory system. Nevertheless, the critical pathophysiological mechanisms involved in neuropathic pain development are poorly understood.
Alexandre G. Maganin, Guilherme R. Souza, Miriam D. Fonseca, Alexandre H. Lopes, Rafaela M. Guimarães, André Dagostin, Nerry T. Cecilio, Atlante S. Mendes, William A. Gonçalves, Conceição E.A. Silva, Francisco Isaac Fernandes Gomes, Lucas M. Mauriz Marques, Rangel L. Silva, Letícia M. Arruda, Denis A. Santana, Henrique Lemos, Lei Huang, Marcela Davoli-Ferreira, Danielle Santana-Coelho, Morena B. Sant’Anna, Ricardo Kusuda, Jhimmy Talbot, Gabriela Pacholczyk, Gabriela A. Buqui, Norberto P. Lopes, Jose C. Alves-Filho, Ricardo M. Leão, Jason C. O’Connor, Fernando Q. Cunha, Andrew Mellor, Thiago M. Cunha   +30 more
doaj   +1 more source

On the breeding habits of the Cowry Erronea errones (Linne) [PDF]

, 1954
Cowries are fairly common in the shallow a reas of Palk Bay and Gulf of Mannar. The species commonly found in the area between Mandapam Camp and Mandapam has been ide ntified as Erronea errones ...
Natarajan, A V
core  

Immune–proteo–metabolomic changes link to Aβ and tau pathology in Alzheimer disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Tryptophan metabolism is increasingly implicated in Alzheimer's disease (AD), particularly through aryl hydrocarbon receptor (AhR) ligands that influence neuroinflammation. However, their relationships with core AD pathology—amyloid‐β (A) and tau (T) deposition—and associated immune–proteomic alterations remain unclear. METHODS We
Meng Wang, Maria Buthut, Jenny Meinhardt, Carolin Otto, Gerardina Gallaccio, Camila Fernández‐Zapata, Matteo Teves, Claudia Samol, Katja Dettmer, Simon Heckscher, Sakshi Kamboj, Yozlem Bahar, Christian Conrad, Christian Böttcher, Desiree Kunkel, Klemens Ruprecht, Friedemann Paul, Peter J. Oefner, Helena Radbruch, Wolfram Gronwald, Harald Prüß, Chotima Böttcher   +21 more
wiley   +1 more source

Structure of a Product of a Fluorescence Reaction of 3-Hydroxykynurenine

Chemical and Pharmaceutical Bulletin, 1970
A product of fluorescence reaction of 3-hydroxykynurenine with p-toluenesulfonylchloride was separated and its structure was investigated. A reaction product of 2-amino-3-hydroxyacetophenone, which has the same configuration of carbonyl, amino and hydroxyl groups, with p-toluenesulfonylchloride was also studied.
WATANABE, MITSUO, TAMURA, ZENZO, OKADA, MASASHI   +2 more
openaire   +2 more sources

Maintenance of Gut Microbial Balance via the Kynurenine Pathway Improves Larval Performance and Resistance to Bacillus thuringiensis in Spodoptera exigua

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
CRISPR/Cas9‐mediated deletion of kmo in Spodoptera exigua abolished 8‐HQA production, disrupted gut microbial homeostasis, and promoted Enterococcus dominance in gut and oral secretion. Mutants exhibited impaired growth, delayed development, and increased susceptibility to Bacillus thuringiensis, highlighting a conserved role of the kynurenine pathway ...
Daniel Pinos, Elena García‐Marín, Beatriz Ramírez‐Serrano, Luis Benavent‐Albarracín, Jordi Gamir, Cristina M. Crava   +5 more
wiley   +1 more source

Research review: the role of cytokines in depression in adolescents: a systematic review [PDF]

, 2013
Background: While cytokines have been implicated in the pathophysiology of depression in adults, the potential role in younger age groups such as adolescents is less clear.
Abbasi, Andrade, Angold, APA, Arango, Babcock, Banks, Bao, Bartlett, Baune, Baune, Baune, Baune, Benes, Bengtsson, Bet, Birmaher, Birmaher, Bluthe, Brambilla, Breder, Bufalino, Cao, Capuron, Capuron, Capuron, Carlezon, Caserta, Caspi, Cavanagh, Chaiton, Connor, Copeland, Craen, D'mello, Danese, Danese, Danese, Dantzer, Dantzer, Dantzer, Dantzer, Deinzer, Dixon, Dowlati, Du, Du, Du, Dunn, Einvik, Ericsson, Eyre, Eyre, Fabry, Fagundes, Fertuzinhos, Fischer, Fisher, Frenois, Funk, Gabbay, Gabbay, Gabbay, Gimeno, Godbout, Goebel, Goldstein, Goodyer, Haroon, Henje Blom, Hill, Hood, Howren, Irwin, Irwin, Jaffee, Janelidze, Janssen, Jun, Kamata, Karg, Kaufman, Kendell, Kent, Khairova, Kilbourn, Kim, Kim, Komaki, Koo, Kovacs, Krishnan, Kronfol, Kronfol, Kubera, Kuo, Leo, Liberati, Lin, Loftis, Madrigal, Maes, Maes, Maes, Maes, Maes, Maes, Maes, Malenka, Mann, McCrory, Mcdermott, McGuffin, McGuffin, McKittrick, McNally, Meaney, Mendlewicz, Mendlovic, Merali, Mill, Miller, Miller, Miller, Misener, Morales, Moussavi, Muller, Nanni, Nemets, Nerozzi, O'brien, O'brien, O'connor, Palucha, Pandey, Pandey, Pavon, Pedersen, Peng, PGC, Pittenger, Qin, Quinones, Raggi, Raison, Ransahoff, Risch, Rooij, Rosa, Rothermundt, Rothwell, Ruhe, Sas, Schleifer, Schleifer, Schwarcz, Schwarz, Shain, Sharpley, Sluzewska, Smith, Solomon, Song, Steensberg, Steptoe, Sun, Sutcigil, Szczepankiewicz, Szelenyi, Taler, Talge, Targum, Taylor, Tonelli, Tuglu, Tyring, Udina, Uher, Ustun, Verthelyi, Watkins, Weaver, Weissman, West, Wilson, Wolf, Worns, Xia, Yirmiya, Yirmiya, Zisook   +191 more
core   +1 more source

Impact of Alcohol Intake on Parkinson's Disease Risk and Progression: A Systematic Review and Dose–Response Meta‐Analysis of Prospective Studies

Movement Disorders, Volume 41, Issue 4, Page 843-855, April 2026.
Abstract The association between alcohol consumption and Parkinson's disease (PD) risk remains unclear, whereas smoking has an inverse relationship with the disease. This study systematically reviewed and meta‐analyzed 16 studies (2014–2024) from PubMed, Scopus, Web of Science, MEDLINE, and the Cochrane Library to assess the relationship between ...
Sahar Hemeda, Mohammed Elmadani, Mohammed Merzah, Aseel Odeh, Evelyn Pintér, István Balás, József Janszky, Dávid Pintér, Norbert Kovács   +8 more
wiley   +1 more source