Results 71 to 80 of about 5,521 (201)

Immune–proteo–metabolomic changes link to Aβ and tau pathology in Alzheimer disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Tryptophan metabolism is increasingly implicated in Alzheimer's disease (AD), particularly through aryl hydrocarbon receptor (AhR) ligands that influence neuroinflammation. However, their relationships with core AD pathology—amyloid‐β (A) and tau (T) deposition—and associated immune–proteomic alterations remain unclear. METHODS We
Meng Wang, Maria Buthut, Jenny Meinhardt, Carolin Otto, Gerardina Gallaccio, Camila Fernández‐Zapata, Matteo Teves, Claudia Samol, Katja Dettmer, Simon Heckscher, Sakshi Kamboj, Yozlem Bahar, Christian Conrad, Christian Böttcher, Desiree Kunkel, Klemens Ruprecht, Friedemann Paul, Peter J. Oefner, Helena Radbruch, Wolfram Gronwald, Harald Prüß, Chotima Böttcher   +21 more
wiley   +1 more source

Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice

The Journal of Clinical Investigation, 2022
Neuropathic pain is one of the most important clinical consequences of injury to the somatosensory system. Nevertheless, the critical pathophysiological mechanisms involved in neuropathic pain development are poorly understood.
Alexandre G. Maganin, Guilherme R. Souza, Miriam D. Fonseca, Alexandre H. Lopes, Rafaela M. Guimarães, André Dagostin, Nerry T. Cecilio, Atlante S. Mendes, William A. Gonçalves, Conceição E.A. Silva, Francisco Isaac Fernandes Gomes, Lucas M. Mauriz Marques, Rangel L. Silva, Letícia M. Arruda, Denis A. Santana, Henrique Lemos, Lei Huang, Marcela Davoli-Ferreira, Danielle Santana-Coelho, Morena B. Sant’Anna, Ricardo Kusuda, Jhimmy Talbot, Gabriela Pacholczyk, Gabriela A. Buqui, Norberto P. Lopes, Jose C. Alves-Filho, Ricardo M. Leão, Jason C. O’Connor, Fernando Q. Cunha, Andrew Mellor, Thiago M. Cunha   +30 more
doaj   +1 more source

Maintenance of Gut Microbial Balance via the Kynurenine Pathway Improves Larval Performance and Resistance to Bacillus thuringiensis in Spodoptera exigua

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
CRISPR/Cas9‐mediated deletion of kmo in Spodoptera exigua abolished 8‐HQA production, disrupted gut microbial homeostasis, and promoted Enterococcus dominance in gut and oral secretion. Mutants exhibited impaired growth, delayed development, and increased susceptibility to Bacillus thuringiensis, highlighting a conserved role of the kynurenine pathway ...
Daniel Pinos, Elena García‐Marín, Beatriz Ramírez‐Serrano, Luis Benavent‐Albarracín, Jordi Gamir, Cristina M. Crava   +5 more
wiley   +1 more source

Impact of Alcohol Intake on Parkinson's Disease Risk and Progression: A Systematic Review and Dose–Response Meta‐Analysis of Prospective Studies

Movement Disorders, Volume 41, Issue 4, Page 843-855, April 2026.
Abstract The association between alcohol consumption and Parkinson's disease (PD) risk remains unclear, whereas smoking has an inverse relationship with the disease. This study systematically reviewed and meta‐analyzed 16 studies (2014–2024) from PubMed, Scopus, Web of Science, MEDLINE, and the Cochrane Library to assess the relationship between ...
Sahar Hemeda, Mohammed Elmadani, Mohammed Merzah, Aseel Odeh, Evelyn Pintér, István Balás, József Janszky, Dávid Pintér, Norbert Kovács   +8 more
wiley   +1 more source

Differential Analysis of IAA Anabolism Pathway Based on Bacillus cereus, Bacillus subtilis and Bacillus safensis Genome

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
Three Bacillus species isolated from Platycladus orientalis rhizosphere in Taihang Mountains: Bacillus cereus has 3 IAA synthesis pathways (TAM, IAM, IPyA); Bacillus subtilis has IAM/IPyA; and Bacillus safensis only has IPyA (via whole‐genome sequencing).
Dongyue Hou, Xuejie Zhai, Kezhong Zhang, Jinteng Cui   +3 more
wiley   +1 more source

Research review: the role of cytokines in depression in adolescents: a systematic review [PDF]

, 2013
Background: While cytokines have been implicated in the pathophysiology of depression in adults, the potential role in younger age groups such as adolescents is less clear.
Abbasi, Andrade, Angold, APA, Arango, Babcock, Banks, Bao, Bartlett, Baune, Baune, Baune, Baune, Benes, Bengtsson, Bet, Birmaher, Birmaher, Bluthe, Brambilla, Breder, Bufalino, Cao, Capuron, Capuron, Capuron, Carlezon, Caserta, Caspi, Cavanagh, Chaiton, Connor, Copeland, Craen, D'mello, Danese, Danese, Danese, Dantzer, Dantzer, Dantzer, Dantzer, Deinzer, Dixon, Dowlati, Du, Du, Du, Dunn, Einvik, Ericsson, Eyre, Eyre, Fabry, Fagundes, Fertuzinhos, Fischer, Fisher, Frenois, Funk, Gabbay, Gabbay, Gabbay, Gimeno, Godbout, Goebel, Goldstein, Goodyer, Haroon, Henje Blom, Hill, Hood, Howren, Irwin, Irwin, Jaffee, Janelidze, Janssen, Jun, Kamata, Karg, Kaufman, Kendell, Kent, Khairova, Kilbourn, Kim, Kim, Komaki, Koo, Kovacs, Krishnan, Kronfol, Kronfol, Kubera, Kuo, Leo, Liberati, Lin, Loftis, Madrigal, Maes, Maes, Maes, Maes, Maes, Maes, Maes, Malenka, Mann, McCrory, Mcdermott, McGuffin, McGuffin, McKittrick, McNally, Meaney, Mendlewicz, Mendlovic, Merali, Mill, Miller, Miller, Miller, Misener, Morales, Moussavi, Muller, Nanni, Nemets, Nerozzi, O'brien, O'brien, O'connor, Palucha, Pandey, Pandey, Pavon, Pedersen, Peng, PGC, Pittenger, Qin, Quinones, Raggi, Raison, Ransahoff, Risch, Rooij, Rosa, Rothermundt, Rothwell, Ruhe, Sas, Schleifer, Schleifer, Schwarcz, Schwarz, Shain, Sharpley, Sluzewska, Smith, Solomon, Song, Steensberg, Steptoe, Sun, Sutcigil, Szczepankiewicz, Szelenyi, Taler, Talge, Targum, Taylor, Tonelli, Tuglu, Tyring, Udina, Uher, Ustun, Verthelyi, Watkins, Weaver, Weissman, West, Wilson, Wolf, Worns, Xia, Yirmiya, Yirmiya, Zisook   +191 more
core   +1 more source

Dynamic Factor Analysis for Sparse and Irregular Longitudinal Data: An Application to Metabolite Measurements in a COVID‐19 Study

Statistics in Medicine, Volume 45, Issue 6-7, March 2026.
ABSTRACT Factor analysis (FA) can be used to identify key biomarkers in biological processes by assuming that latent biological pathways (statistically, “latent factors”) drive the activity of measurable biomarkers (“observed variables”). However, biological pathways often interact, meaning that the classical FA assumption of independence between ...
Jiachen Cai, Robert J. B. Goudie, Brian D. M. Tom   +2 more
wiley   +1 more source

A pilot study of maternal vitamin D status and its association with breast milk and infant gut metabolites

Physiological Reports, Volume 14, Issue 5, March 2026.
Vitamin D status in our pilot study was associated with higher levels of certain amino acids and hexanoic acid in breast milk and metabolites in infant stool samples. Abstract Human milk contains multiple bioactive components, many of which are influenced by the mother's nutritional status.
Alyssa S. Gutierrez, Katherine E. Chetta, Santosh Thapa, Sigmund J. Haidacher, Kathleen M. Hoch, John E. Baatz, Anthony M. Haag, Numan Oezguen, Thomas D. Horvath, Carol L. Wagner, Melinda A. Engevik   +10 more
wiley   +1 more source

Kynurenine pathway metabolism and the microbiota-gut-brain axis [PDF]

, 2018
It has become increasingly clear that the gut microbiota influences not only gastrointestinal physiology but also central nervous system (CNS) function by modulating signalling pathways of the microbiota-gut-brain axis.
Clarke, Gerard, Cryan, John F., Dinan, Timothy G., Kennedy, Paul J.   +3 more
core   +1 more source

NAD+ Homeostasis Attenuates Japanese Encephalitis Virus Infection Progression

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
JEV infection in brain tissue triggers inflammation and stress in neuronal cells, leading to NAD+ depletion via the overactivation of PARPs and SIRTs. While compensatory biosynthetic pathways (de novo and salvage) were upregulated, the NAD+ level fell critically. In vitro NAMPT inhibition exacerbates this deficit and viral load.
Takele Adugna Kassegn, Zhancheng Tian, Junzheng Du, Qingli Niu, Jifei Yang, Zhang Hongge, Yuqing Song, Fengxue Chai, Zhonghui Zhang, Guiquan Guan, Hong Yin   +10 more
wiley   +1 more source