Results 71 to 80 of about 3,496 (164)

Distinct effects of fish oil and olive oil on neurotransmitter metabolism, gut microbiota, and gut–brain axis dysfunction, depression-like behaviors in CUMS-induced rats

Journal of Agriculture and Food Research
The pathogenesis of depression involves both physiological and psychological factors. Through the gut-brain axis, neurotransmitters, gut barrier function, and microbiota jointly regulate neuroinflammation, influencing brain function and emotional ...
Pin-Yu Chiang, Chen-Yu Liao, Chin-Ying Wu, Wei-Yu Kao, Yi-Tung Lin, Pin-Hui Wei, Te-Hsuan Tung, Shih-Yi Huang   +7 more
doaj   +1 more source

The excretion of kynurenine and 3-hydroxykynurenine by man [PDF]

Biochemical Journal, 1954
C E, DALGLIESH, S, TEKMAN
openaire   +3 more sources

Exploring the Microbiome-Kynurenine Axis in Mild Cognitive Impairment: From Gut to Brain

Journal of Integrative Neuroscience
Mild cognitive impairment (MCI) represents a critical prodromal stage of Alzheimer’s disease. This review synthesizes current evidence to present a coherent pathological cascade driving MCI progression: gut microbiota dysbiosis (e.g., enrichment of ...
Jiaxing Zhu, Haihua Xie, Yingke Ouyang, Ting Zhu, Qianyan Liu, Weiai Liu, Shulin Xiong, Mi Liu   +7 more
doaj   +1 more source

Rapamycin Treatment Ameliorates Age-Related Accumulation of Toxic Metabolic Intermediates in Brains of the Ts65Dn Mouse Model of Down Syndrome and Aging

Frontiers in Aging Neuroscience, 2018
Down syndrome (DS), caused by trisomy of chromosome 21, is the most common genetic cause of intellectual disability. Individuals with DS exhibit changes in neurochemistry and neuroanatomy that worsen with age, neurological delay in learning and memory ...
Nathan Duval, Guido N. Vacano, David Patterson   +2 more
doaj   +1 more source

Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition

Frontiers in Molecular Biosciences, 2019
The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metabolites in the kynurenine pathway, however, are potentially toxic, particularly 3-hydroxykynurenine, 3-hydroxyanthranilic acid, and quinolinic acid ...
Robert S. Phillips, Robert S. Phillips, Emma Carine Iradukunda, Tamera Hughes, J. Phillip Bowen   +4 more
doaj   +1 more source

The Synthesis of 3-Hydroxykynurenine (+Chromogen) [PDF]

Bulletin of the Chemical Society of Japan, 1950
Yoshimasa Hirata, Koji Nakanishi
openaire   +1 more source

Inhibition of 3-Hydroxykynurenine Transaminase from Aedes aegypti and Anopheles gambiae: A Mosquito-Specific Target to Combat the Transmission of Arboviruses. [PDF]

ACS Bio Med Chem Au, 2023
Maciel LG, Ferraz MVF, Oliveira AA, Lins RD, Dos Anjos JV, Guido RVC, Soares TA.   +6 more
europepmc   +1 more source

A second generation of 1,2,4-oxadiazole derivatives with enhanced solubility for inhibition of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti. [PDF]

RSC Med Chem, 2021
Maciel LG, Barbosa ADS, de Alencar-Filho EB, Soares TA, Dos Anjos JV.   +4 more
europepmc   +1 more source

Neurotoxic effects of citronellol induced by the conversion of kynurenine to 3-hydroxykynurenine

Journal of Hazardous Materials
Citronellol is widely utilized in consumer products, including cosmetics, fragrances, and household items. However, despite being considered a relatively safe chemical, the health effects and toxicity mechanisms associated with exposure to high concentrations of citronellol, based on product content, remain inadequately understood.
Seong Soon Kim, Suhyun Kim, Yeonhwa Kim, Youngran Ha, Hyojin Lee, Hyunji Im, Jung Yoon Yang, Dae-Seop Shin, Kyu-Seok Hwang, Yuji Son, Sung Bum Park, Ki Young Kim, Han-Seul Lee, Ki-Tae Kim, Sung-Hee Cho, Myung Ae Bae, Hae-Chul Park   +16 more
openaire   +2 more sources

Sex differences in peripheral and central dysregulation of the kynurenine pathway in Parkinson’s disease

npj Parkinson's Disease
We previously demonstrated that kynurenine pathway (KP) dysregulation associates with Parkinson’s disease (PD) and its symptoms. Here, we profiled 16 KP-related markers in a second, independent cohort; plasma: n = 202 (116 PD (“OFF”), 86 controls); CSF ...
Leslie C. Jellen, Martha L. Escobar Galvis, Qiong Sha, Christine Isaguirre, Amy Johnson, Zach Madaj, Mechelle M. Lewis, Ryan D. Sheldon, Lan Kong, Xuemei Huang, Lena Brundin   +10 more
doaj   +1 more source