Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis [PDF]
Cell Reports, 2023 Summary: Kynurenine monooxygenase (KMO) blockade protects against multiple organ failure caused by acute pancreatitis (AP), but the link between KMO and systemic inflammation has eluded discovery until now.
Alastair J. Hayes +19 more
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Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice
Neurobiology of Disease, 2006 The brain levels of the endogenous excitotoxin quinolinic acid (QUIN) and its bioprecursor, the free radical generator 3-hydroxykynurenine (3-HK), are elevated in early stage Huntington disease (HD).
Paolo Guidetti +9 more
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Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects. [PDF]
Neuroscience, 2017 Sathyasaikumar KV +6 more
europepmc +2 more sources
Polypeptide Modification and Cross-Linking by Oxidized 3-Hydroxykynurenine [PDF]
Biochemistry, 2000 3-Hydroxykynurenine (3OHKyn) is present in the mammalian lens as a UV filter and is formed from kynurenine in the tryptophan metabolic pathway. 3OHKyn is a readily autoxidized o-aminophenol which binds to proteins in vitro. The lens, particularly its central region, the nucleus, becomes increasingly oxidized with age.
Aquilina, J., Carver, J., Truscott, R.
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Kynurenine Pathway in Diabetes Mellitus—Novel Pharmacological Target?
Cells, 2023 The tryptophan–kynurenine pathway (Trp–KYN) is the major route for tryptophan conversion in the brain and in the periphery. Kynurenines display a wide range of biological actions (which are often contrasting) such as cytotoxic/cytoprotective, oxidant ...
Kamila Kozieł, Ewa M. Urbanska
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Role of Kynurenine Pathway in Oxidative Stress during Neurodegenerative Disorders
Cells, 2021 Neurodegenerative disorders are chronic and life-threatening conditions negatively affecting the quality of patients’ lives. They often have a genetic background, but oxidative stress and mitochondrial damage seem to be at least partly responsible for ...
Adrian Mor +3 more
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The Kynurenine Pathway in Obese Middle-Aged Women with Normoglycemia and Type 2 Diabetes
Metabolites, 2022 We examined the relationships of tryptophan (Trp) and the metabolites of the kynurenine pathway (KP) to the occurrence of type 2 diabetes (T2D) and metabolic risk factors in obese middle-aged women.
Justyna Kubacka +4 more
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Activation of NAD(P)H oxidase by tryptophan-derived 3-hydroxykynurenine accelerates endothelial apoptosis and dysfunction in vivo. [PDF]
Circ Res, 2014 Wang Q +6 more
europepmc +2 more sources
Frontiers in Immunology, 2023 There is an increasing interest in the pathophysiological role of the kynurenine pathway of tryptophan metabolism in the regulation of immune function and inflammation.
Arduino A. Mangoni +2 more
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Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma
Frontiers in Oncology, 2020 Dysregulation of the kynurenine pathway has been regarded as a mechanism of tumor immune escape by the enzymatic activity of indoleamine 2, 3 dioxygenase and kynurenine production. However, the immune-modulatory properties of other kynurenine metabolites
Soudabeh Rad Pour +17 more
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