Cytotoxicity of 3-hydroxykynurenine in a neuronal hybrid cell line
Brain Research, 1989 The toxicity of 3-hydroxykynurenine (3HK), an endogenous tryptophan metabolite which is markedly elevated in rat CNS tissue as a result of neonatal vitamin B-6 deficiency, was investigated in a neuronally derived hybrid cell line (N18-RE-105). At concentrations in excess of 100 microM, 3HK was toxic to greater than 85% of cultured cells over the course
Tomáš Guilarte, T R Guilarte
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The kynurenine pathway: an immunometabolic bridge linking systemic inflammation to neuroaxonal vulnerability in multiple sclerosis [PDF]
Frontiers in Cellular NeuroscienceMultiple sclerosis (MS) extends beyond focal autoimmune demyelination, with progressive neurodegeneration and cognitive impairment arising from mechanisms not fully explained by inflammatory lesions alone.
José Luis Maldonado-García +9 more
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Pregnancy complications affect kynurenine pathway metabolite concentrations in umbilical cord blood [PDF]
Reproductive Biology and EndocrinologyBackground Tryptophan and its kynurenine pathway (KP) metabolites play key roles in modulating the immune system and vasculature, and exhibit both pro- and antioxidant properties, making them crucial for a healthy pregnancy and fetal development ...
Michelle Broekhuizen +10 more
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Tryptophan metabolites clearance in hemodialyzed patients [PDF]
Amino AcidsHemodialysis (HD) and hemodiafiltration (HDF) procedures have limited efficacy regarding removal of selected toxins. Tryptophan (Trp) metabolites formed through the kynurenine (KYN) pathway are known to contribute to kidney failure (KF) complications ...
Izabela Zakrocka +8 more
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Metabolic alterations in diabetic patients: aqueous humor profiling for biomarker discovery [PDF]
Amino AcidsDiabetic retinopathy, a leading cause of vision loss in working-age populations, is a severe complication of diabetes mellitus. Metabolomics, a key approach in systems biology, offers insights into the complex pathophysiology of diabetes by analyzing low-
Arturs Zemitis +6 more
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Cell Reports, 2023 Summary: Kynurenine monooxygenase (KMO) blockade protects against multiple organ failure caused by acute pancreatitis (AP), but the link between KMO and systemic inflammation has eluded discovery until now.
Alastair J. Hayes +19 more
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Kynurenine Pathway in Diabetes Mellitus—Novel Pharmacological Target?
Cells, 2023 The tryptophan–kynurenine pathway (Trp–KYN) is the major route for tryptophan conversion in the brain and in the periphery. Kynurenines display a wide range of biological actions (which are often contrasting) such as cytotoxic/cytoprotective, oxidant ...
Kamila Kozieł, Ewa M. Urbanska
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Role of Kynurenine Pathway in Oxidative Stress during Neurodegenerative Disorders
Cells, 2021 Neurodegenerative disorders are chronic and life-threatening conditions negatively affecting the quality of patients’ lives. They often have a genetic background, but oxidative stress and mitochondrial damage seem to be at least partly responsible for ...
Adrian Mor +3 more
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The mediating role of the kynurenine pathway in longitudinal associations between dietary intake and quality of life in colorectal cancer survivors up to 12 months posttreatment. [PDF]
Int J CancerWhat's New? Many colorectal cancer survivors experience reduced health‐related quality of life (HRQoL), often lasting years after diagnosis. Healthy dietary patterns and even individual macro‐ and micronutrients, however, can potentially improve HRQoL.
Holthuijsen DDB +14 more
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Kynurenic acid and 3-hydroxykynurenine production from d-kynurenine in mice [PDF]
Brain Research, 2012 Robert Schwarcz
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