Results 11 to 20 of about 5,596 (203)

Reduced plasma concentrations of vitamin B6 and increased plasma concentrations of the neurotoxin 3-hydroxykynurenine are associated with nodding syndrome: a case control study in Gulu and Amuru districts, Northern Uganda [PDF]

The Pan African Medical Journal, 2016
INTRODUCTION: nodding syndrome was first reported in Uganda in 2003 among internally displaced populations. Risk factors for the syndrome remain unknown.
James Henry Obol, Denis Anywar Arony, Ronald Wanyama, Kenneth Luryama Moi, Bongomin Bodo, Patrick Olwedo Odong, Michael Odida   +6 more
doaj   +2 more sources

Cytotoxicity of 3-hydroxykynurenine in a neuronal hybrid cell line

Brain Research, 1989
The toxicity of 3-hydroxykynurenine (3HK), an endogenous tryptophan metabolite which is markedly elevated in rat CNS tissue as a result of neonatal vitamin B-6 deficiency, was investigated in a neuronally derived hybrid cell line (N18-RE-105). At concentrations in excess of 100 microM, 3HK was toxic to greater than 85% of cultured cells over the course
Clifford L Eastman, Tomáš R Guilarte
exaly   +3 more sources

The kynurenine pathway: an immunometabolic bridge linking systemic inflammation to neuroaxonal vulnerability in multiple sclerosis [PDF]

Frontiers in Cellular Neuroscience
Multiple sclerosis (MS) extends beyond focal autoimmune demyelination, with progressive neurodegeneration and cognitive impairment arising from mechanisms not fully explained by inflammatory lesions alone.
José Luis Maldonado-García, José Luis Maldonado-García, Lissette Haydee García-Mena, Eduardo Alberto Ferat-Peláez, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, Argelia Esperanza Rojas-Mayorquín, Manuel Iván Girón-Pérez, Daniel Ortuño-Sahagún, Lenin Pavón   +9 more
doaj   +2 more sources

Pregnancy complications affect kynurenine pathway metabolite concentrations in umbilical cord blood [PDF]

Reproductive Biology and Endocrinology
Background Tryptophan and its kynurenine pathway (KP) metabolites play key roles in modulating the immune system and vasculature, and exhibit both pro- and antioxidant properties, making them crucial for a healthy pregnancy and fetal development ...
Michelle Broekhuizen, Heike Allenberg, Claude P. van der Ley, Sofie K. M. van Zundert, Zongye Cai, Martijn van Faassen, Daphne Merkus, A. H. Jan Danser, Anja Lange, Irwin K. M. Reiss, Matthias Heckmann   +10 more
doaj   +2 more sources

Tryptophan metabolites clearance in hemodialyzed patients [PDF]

Amino Acids
Hemodialysis (HD) and hemodiafiltration (HDF) procedures have limited efficacy regarding removal of selected toxins. Tryptophan (Trp) metabolites formed through the kynurenine (KYN) pathway are known to contribute to kidney failure (KF) complications ...
Izabela Zakrocka, Radosław Mlak, Natalia Moniczewska, Sylwia Boczkowska, Renata Kloc, Tomasz Kocki, Ewa M. Urbańska, Wojciech Załuska, Andreas Kronbichler   +8 more
doaj   +2 more sources

Metabolic alterations in diabetic patients: aqueous humor profiling for biomarker discovery [PDF]

Amino Acids
Diabetic retinopathy, a leading cause of vision loss in working-age populations, is a severe complication of diabetes mellitus. Metabolomics, a key approach in systems biology, offers insights into the complex pathophysiology of diabetes by analyzing low-
Arturs Zemitis, Lelde Svjascenkova, Sandra Bleidele, Alberts Veitners, Juris Vanags, Kristaps Klavins, Guna Laganovska   +6 more
doaj   +2 more sources

The mediating role of the kynurenine pathway in longitudinal associations between dietary intake and quality of life in colorectal cancer survivors up to 12 months posttreatment. [PDF]

Int J Cancer
What's New? Many colorectal cancer survivors experience reduced health‐related quality of life (HRQoL), often lasting years after diagnosis. Healthy dietary patterns and even individual macro‐ and micronutrients, however, can potentially improve HRQoL.
Holthuijsen DDB, Rijnhart JJM, van Roekel EH, Bours MJL, Ueland PM, Breukink SO, Janssen-Heijnen MLG, Konsten JL, Keulen ETP, McCann A, Brezina S, Gigic B, Ose J, Weijenberg MP, Eussen SJPM.   +14 more
europepmc   +2 more sources

Stage-Dependent Changes in Kynurenine Pathway Enzyme Expression Suggest Immune-Related Involvement in Bladder Cancer Progression. [PDF]

Int J Urol
ABSTRACT L‐tryptophan (Trp) metabolism through the L‐kynurenine (Kyn) pathway contributes to immune escape in neoplasms, including bladder cancer (BC). Indoleamine 2,3‐dioxygenase‐1 (IDO1) is a key enzyme, and its catabolites—Kyn, 3‐hydroxykynurenine (3HK), and 3‐hydroxyanthranilate (3HAA)—depend on other enzymes and play a crucial role in ...
Lemes DE, Santos AÁS, de Oliveira JL, Roman-Ramos H, Moreno ACR, Camacho CP, Pontes-Junior J, Dellê H.   +7 more
europepmc   +2 more sources

The Kynurenine Pathway in Obese Middle-Aged Women with Normoglycemia and Type 2 Diabetes

Metabolites, 2022
We examined the relationships of tryptophan (Trp) and the metabolites of the kynurenine pathway (KP) to the occurrence of type 2 diabetes (T2D) and metabolic risk factors in obese middle-aged women.
Justyna Kubacka, Magdalena Staniszewska, Ilona Sadok, Grazyna Sypniewska, Anna Stefanska   +4 more
doaj   +1 more source

Kynurenine Pathway in Diabetes Mellitus—Novel Pharmacological Target?

Cells, 2023
The tryptophan–kynurenine pathway (Trp–KYN) is the major route for tryptophan conversion in the brain and in the periphery. Kynurenines display a wide range of biological actions (which are often contrasting) such as cytotoxic/cytoprotective, oxidant ...
Kamila Kozieł, Ewa M. Urbanska
doaj   +1 more source