Results 21 to 30 of about 5,596 (203)

Role of Kynurenine Pathway in Oxidative Stress during Neurodegenerative Disorders

Cells, 2021
Neurodegenerative disorders are chronic and life-threatening conditions negatively affecting the quality of patients’ lives. They often have a genetic background, but oxidative stress and mitochondrial damage seem to be at least partly responsible for ...
Adrian Mor, Anna Tankiewicz-Kwedlo, Anna Krupa, Dariusz Pawlak   +3 more
doaj   +1 more source

A systematic review and meta-analysis of the kynurenine pathway of tryptophan metabolism in rheumatic diseases

Frontiers in Immunology, 2023
There is an increasing interest in the pathophysiological role of the kynurenine pathway of tryptophan metabolism in the regulation of immune function and inflammation.
Arduino A. Mangoni, Arduino A. Mangoni, Angelo Zinellu   +2 more
doaj   +1 more source

Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma

Frontiers in Oncology, 2020
Dysregulation of the kynurenine pathway has been regarded as a mechanism of tumor immune escape by the enzymatic activity of indoleamine 2, 3 dioxygenase and kynurenine production. However, the immune-modulatory properties of other kynurenine metabolites
Soudabeh Rad Pour, Hiromasa Morikawa, Narsis A. Kiani, Narsis A. Kiani, David Gomez-Cabrero, David Gomez-Cabrero, Alistair Hayes, Xiaozhong Zheng, Maria Pernemalm, Janne Lehtiö, Damian J. Mole, Johan Hansson, Johan Hansson, Hanna Eriksson, Hanna Eriksson, Jesper Tegnér, Jesper Tegnér, Jesper Tegnér   +17 more
doaj   +1 more source

Brain Versus Blood: A Systematic Review on the Concordance Between Peripheral and Central Kynurenine Pathway Measures in Psychiatric Disorders

Frontiers in Immunology, 2021
ObjectiveDisturbances in the kynurenine pathway have been implicated in the pathophysiology of psychotic and mood disorders, as well as several other psychiatric illnesses.
Katrien Skorobogatov, Katrien Skorobogatov, Livia De Picker, Livia De Picker, Robert Verkerk, Violette Coppens, Violette Coppens, Marion Leboyer, Marion Leboyer, Marion Leboyer, Marion Leboyer, Norbert Müller, Manuel Morrens, Manuel Morrens   +13 more
doaj   +1 more source

Tryptophan Metabolites, Cytokines, and Fatty Acid Binding Protein 2 in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Biomedicines, 2021
Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) differ for triggers, mode of start, associated symptoms, evolution, and biochemical traits.
Manuela Simonato, Stefano Dall’Acqua, Caterina Zilli, Stefania Sut, Romano Tenconi, Nicoletta Gallo, Paolo Sfriso, Leonardo Sartori, Francesco Cavallin, Ugo Fiocco, Paola Cogo, Paolo Agostinis, Anna Aldovini, Daniela Bruttomesso, Renzo Marcolongo, Stefano Comai, Aldo Baritussio   +16 more
doaj   +1 more source

Detection of 3-hydroxykynurenine in a plant pathogenic fungus [PDF]

Biochemical Journal, 2003
A redox-active compound has been purified from the barley powdery mildew fungus Blumeria (Erysiphe) graminis f. sp. hordei. A combination of spectrophotometry, MS and NMR has identified it as 3-hydroxykynurenine (3OHKyn). This compound, never previously detected in any fungus or pathogen, is best known for its role in vertebrate cataracts.
Wilson, T., Thomsen, K., Petersen, B., Duus, J., Oliver, Richard   +4 more
openaire   +3 more sources

Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis [PDF]

, 2016
The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the trigger for induction of the KP, driving a complex cascade of production ...
Bianca Varney, Bruce J. Brew, Bruce J. Brew, Bruce J. Brew, Chai K. Lim, Gayathri Sundaram, Mei Li Ng, Michael D. Lovelace, Michael D. Lovelace, Nunzio Franco, Saparna Pai   +10 more
core   +6 more sources

Kynurenic acid and 3-hydroxykynurenine production from d-kynurenine in mice [PDF]

Brain Research, 2012
Robert Schwarcz
exaly   +2 more sources

Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia

Biomolecules, 2023
Preeclampsia (PE) is a pregnancy-related disorder characterized by high blood pressure and proteinuria in the third trimester. The disease is associated with many metabolic and biochemical changes.
Zainab Abdulameer Jasim, Hussein Kadhem Al-Hakeim, Samaneh Zolghadri, Agata Stanek   +3 more
doaj   +1 more source

An expanding range of targets for kynurenine metabolites of tryptophan [PDF]

, 2013
The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail, Stone, Trevor W., Stoy, Nicholas   +2 more
core   +1 more source