Results 21 to 30 of about 3,496 (164)
The Kynurenine Pathway in Obese Middle-Aged Women with Normoglycemia and Type 2 Diabetes
Metabolites, 2022 We examined the relationships of tryptophan (Trp) and the metabolites of the kynurenine pathway (KP) to the occurrence of type 2 diabetes (T2D) and metabolic risk factors in obese middle-aged women.
Justyna Kubacka +4 more
doaj +1 more source
Frontiers in Immunology, 2023 There is an increasing interest in the pathophysiological role of the kynurenine pathway of tryptophan metabolism in the regulation of immune function and inflammation.
Arduino A. Mangoni +2 more
doaj +1 more source
Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma
Frontiers in Oncology, 2020 Dysregulation of the kynurenine pathway has been regarded as a mechanism of tumor immune escape by the enzymatic activity of indoleamine 2, 3 dioxygenase and kynurenine production. However, the immune-modulatory properties of other kynurenine metabolites
Soudabeh Rad Pour +17 more
doaj +1 more source
Frontiers in Immunology, 2021 ObjectiveDisturbances in the kynurenine pathway have been implicated in the pathophysiology of psychotic and mood disorders, as well as several other psychiatric illnesses.
Katrien Skorobogatov +13 more
doaj +1 more source
Stage-Dependent Changes in Kynurenine Pathway Enzyme Expression Suggest Immune-Related Involvement in Bladder Cancer Progression. [PDF]
Int J UrolABSTRACT L‐tryptophan (Trp) metabolism through the L‐kynurenine (Kyn) pathway contributes to immune escape in neoplasms, including bladder cancer (BC). Indoleamine 2,3‐dioxygenase‐1 (IDO1) is a key enzyme, and its catabolites—Kyn, 3‐hydroxykynurenine (3HK), and 3‐hydroxyanthranilate (3HAA)—depend on other enzymes and play a crucial role in ...
Lemes DE +7 more
europepmc +2 more sources
Biomedicines, 2021 Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) differ for triggers, mode of start, associated symptoms, evolution, and biochemical traits.
Manuela Simonato +16 more
doaj +1 more source
Detection of 3-hydroxykynurenine in a plant pathogenic fungus [PDF]
Biochemical Journal, 2003 A redox-active compound has been purified from the barley powdery mildew fungus Blumeria (Erysiphe) graminis f. sp. hordei. A combination of spectrophotometry, MS and NMR has identified it as 3-hydroxykynurenine (3OHKyn). This compound, never previously detected in any fungus or pathogen, is best known for its role in vertebrate cataracts.
Wilson, T. +4 more
openaire +3 more sources
Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia
Biomolecules, 2023 Preeclampsia (PE) is a pregnancy-related disorder characterized by high blood pressure and proteinuria in the third trimester. The disease is associated with many metabolic and biochemical changes.
Zainab Abdulameer Jasim +3 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2008 The 3-hydroxykynurenine transaminase (3-HKT) gene plays a vital role in the development of malaria parasites by participating in the synthesis of xanthurenic acid, which is involved in the exflagellation of microgametocytes in the midgut of malaria ...
R Vidhyanandhini, N Pradeep Kumar
doaj +1 more source
Scientific Reports, 2022 SARS-CoV-2 causes major disturbances in serum metabolite levels, associated with severity of the immune response. Despite the numerous advantages of urine for biomarker discovery, the potential association between urine metabolites and disease severity ...
Joseph P. Dewulf +12 more
doaj +1 more source