Results 21 to 30 of about 5,521 (201)
Frontiers in Immunology, 2021 ObjectiveDisturbances in the kynurenine pathway have been implicated in the pathophysiology of psychotic and mood disorders, as well as several other psychiatric illnesses.
Katrien Skorobogatov +13 more
doaj +1 more source
Biomedicines, 2021 Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) differ for triggers, mode of start, associated symptoms, evolution, and biochemical traits.
Manuela Simonato +16 more
doaj +1 more source
Kynurenic acid and 3-hydroxykynurenine production from D-kynurenine in mice. [PDF]
Brain Res, 2012 Wang XD +3 more
europepmc +2 more sources
Structure and mechanism of an antibiotics-synthesizing 3-hydroxykynurenine C-methyltransferase. [PDF]
Sci Rep, 2015 AbstractStreptosporangium sibiricum SibL catalyzes the methyl transfer from S-adenosylmethionine (SAM) to 3-hydroxykynurenine (3-HK) to produce S-adenosylhomocysteine (SAH) and 3-hydroxy-4-methyl-kynurenine for sibiromycin biosynthesis. Here, we present the crystal structures of apo-form Ss-SibL, Ss-SibL/SAH binary complex and Ss-SibL/SAH/3-HK ternary ...
Chen SC +9 more
europepmc +4 more sources
Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis [PDF]
, 2016 The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the trigger for induction of the KP, driving a complex cascade of production ...
Bianca Varney +10 more
core +6 more sources
Detection of 3-hydroxykynurenine in a plant pathogenic fungus [PDF]
Biochemical Journal, 2003 A redox-active compound has been purified from the barley powdery mildew fungus Blumeria (Erysiphe) graminis f. sp. hordei. A combination of spectrophotometry, MS and NMR has identified it as 3-hydroxykynurenine (3OHKyn). This compound, never previously detected in any fungus or pathogen, is best known for its role in vertebrate cataracts.
Wilson, T. +4 more
openaire +3 more sources
Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia
Biomolecules, 2023 Preeclampsia (PE) is a pregnancy-related disorder characterized by high blood pressure and proteinuria in the third trimester. The disease is associated with many metabolic and biochemical changes.
Zainab Abdulameer Jasim +3 more
doaj +1 more source
An expanding range of targets for kynurenine metabolites of tryptophan [PDF]
, 2013 The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail +2 more
core +1 more source
The kynurenine pathway and the brain: challenges, controversies and promises [PDF]
, 2017 Research on the neurobiology of the kynurenine pathway has suffered years of relative obscurity because tryptophan degradation, and its involvement in both physiology and major brain diseases, was viewed almost exclusively through the lens of the well ...
Schwarcz, Robert, Stone, Trevor W.
core +1 more source
Memorias do Instituto Oswaldo Cruz, 2008 The 3-hydroxykynurenine transaminase (3-HKT) gene plays a vital role in the development of malaria parasites by participating in the synthesis of xanthurenic acid, which is involved in the exflagellation of microgametocytes in the midgut of malaria ...
R Vidhyanandhini, N Pradeep Kumar
doaj +1 more source