Results 21 to 30 of about 41,015 (259)

Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile [PDF]

, 2014
Tryptophan is an important precursor for chemical entities that ultimately support the biosynthesis of key metabolites. The second stage of tryptophan catabolism is catalysed by kynurenine formamidase, an enzyme that is different between eukaryotes and ...
Zoltner, Martin, Srikannathasan, Velupillai, Hunter, William N., Díaz-Sáez, Laura   +3 more
core   +1 more source

Effects of inflammation on the kynurenine pathway in schizophrenia — a systematic review

Journal of Neuroinflammation, 2020
Background In the last decade, there has been growing evidence that an interaction exists between inflammation and the kynurenine pathway in schizophrenia.
Bruno Pedraz-Petrozzi, Osama Elyamany, Christoph Rummel, Christoph Mulert   +3 more
doaj   +1 more source

RETRACTED ARTICLE: Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis

Nature Communications, 2022
Indoleamine 2,3 dioxygenase-1 (IDO1) catalyzes tryptophan-kynurenine metabolism in many inflammatory and cancer diseases. Of note, acute inflammation that occurs immediately after heart injury is essential for neonatal cardiomyocyte proliferation and ...
Donghong Zhang, Jinfeng Ning, Tharmarajan Ramprasath, Changjiang Yu, Xiaoxu Zheng, Ping Song, Zhonglin Xie, Ming-Hui Zou   +7 more
doaj   +1 more source

Linking major depressive disorder pathogenesis with kynurenine pathway - a literature review

Journal of Education, Health and Sport, 2023
Introduction: Depressive disorders are a significant problem. They lead to suffering, loss of interest and may contribute to suicide attempts. Despite the large number of available medications, 10-35% of patients fail to achieve remission.
Dominik Szawica, Aleksandra Kuźniar, Kamila Fularska, Michał Oleszko, Edward Wąsiewicz   +4 more
doaj   +1 more source

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis [PDF]

, 2009
Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites <i>Trypanosoma brucei rhodesiense</i> or <i>Trypanosoma brucei gambiense</i>, and is a major cause of systemic and neurological disability ...
Barrett, M.P., Stone, T.W., Bradley, B.M., Kennedy, P.G.E., Rodgers, J.   +4 more
core   +1 more source

Plasma Kynurenine Predicts Severity and Complications of Heart Failure and Associates with Established Biochemical and Clinical Markers of Disease

Kidney & Blood Pressure Research, 2019
Background: Kynurenine, a metabolite of the L-tryptophan pathway, plays a pivotal role in neuro-inflammation, cancer immunology, and cardiovascular inflammation, and has been shown to predict cardiovascular events.
Thomas Bernd Dschietzig, Karl-Heinz Kellner, Katrin Sasse, Felix Boschann, Robert Klüsener, Jana Ruppert, Franz Paul Armbruster, Dragic Bankovic, Andreas Meinitzer, Veselin Mitrovic, Christoph Melzer   +10 more
doaj   +1 more source

Kynurenine Acid - Metabolism And Regulation Of Kynurenine Pathway

Journal of Education, Health and Sport, 2017
Kozłowska Magdalena, Kozłowski Piotr. Kynurenine acid - metabolism and regulation of kynurenine pathway. Journal of Education, Health and Sport. 2017;7(7):888-895. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.891286 http://ojs.ukw.edu.pl/index.php/johs/article/view/4815 The journal has had 7 points in Ministry of Science ...
Piotr Kozłowski, Magdalena Kozlowska
openaire   +3 more sources

Neopterin and Kynurenine in Mesangioproliferative Glomerulonephritis

Pteridines, 1998
Serum kynurenine and neopterin concentrations were determined in patients with chronic mesangioproliferative glomerulonephritis with normal renal function and in patients with chronic renal failure. Significantly increased kynurenine and neopterin levels
Martinsons Agris, Rudzite Vera, Widner Bernhard, Fuchs Dietmar   +3 more
doaj   +1 more source

Tryptophan catabolism increases in breast cancer patients compared to healthy controls without affecting the cancer outcome or response to chemotherapy

Journal of Translational Medicine, 2019
Background Indoleamine 2,3-dioxygenase catalyzes the conversion of tryptophan to kynurenine, an immunosuppressive metabolite involved in T regulatory cell differentiation.
Concetta Elisa Onesti, François Boemer, Claire Josse, Stephane Leduc, Vincent Bours, Guy Jerusalem   +5 more
doaj   +1 more source

Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K+ channels

Journal of Pharmacological Sciences, 2015
Kynurenine is a potential contributor to hypotension in animal and human sepsis. The present study was designed to examine whether the voltage-dependent K+ channels encoded by the KCNQ gene family (Kv7 channels) mediate vasodilator effects of kynurenine ...
Kensuke Sakakibara, Guo-Gang Feng, Jiazheng Li, Takahiko Akahori, Yoshitaka Yasuda, Emi Nakamura, Noboru Hatakeyama, Yoshihiro Fujiwara, Hiroyuki Kinoshita   +8 more
doaj   +1 more source