Results 21 to 30 of about 28,282 (229)

Plasma Kynurenine Predicts Severity and Complications of Heart Failure and Associates with Established Biochemical and Clinical Markers of Disease

Kidney & Blood Pressure Research, 2019
Background: Kynurenine, a metabolite of the L-tryptophan pathway, plays a pivotal role in neuro-inflammation, cancer immunology, and cardiovascular inflammation, and has been shown to predict cardiovascular events.
Thomas Bernd Dschietzig, Karl-Heinz Kellner, Katrin Sasse, Felix Boschann, Robert Klüsener, Jana Ruppert, Franz Paul Armbruster, Dragic Bankovic, Andreas Meinitzer, Veselin Mitrovic, Christoph Melzer   +10 more
doaj   +1 more source

Kynurenine Acid - Metabolism And Regulation Of Kynurenine Pathway

Journal of Education, Health and Sport, 2017
Kozłowska Magdalena, Kozłowski Piotr. Kynurenine acid - metabolism and regulation of kynurenine pathway. Journal of Education, Health and Sport. 2017;7(7):888-895. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.891286 http://ojs.ukw.edu.pl/index.php/johs/article/view/4815 The journal has had 7 points in Ministry of Science ...
Piotr Kozłowski, Magdalena Kozlowska
openaire   +3 more sources

Kynurenine Pathway of Tryptophan Metabolism Is Associated with Hospital Mortality in Patients with Acute Respiratory Distress Syndrome: A Prospective Cohort Study

Antioxidants, 2022
Acute respiratory distress syndrome (ARDS) involves dysregulated immune-inflammatory responses, characterized by severe oxidative stress and high mortality.
Li-Chung Chiu, Hsiang-Yu Tang, Chun-Ming Fan, Chi-Jen Lo, Han-Chung Hu, Kuo-Chin Kao, Mei-Ling Cheng   +6 more
doaj   +1 more source

Neopterin and Kynurenine in Mesangioproliferative Glomerulonephritis

Pteridines, 1998
Serum kynurenine and neopterin concentrations were determined in patients with chronic mesangioproliferative glomerulonephritis with normal renal function and in patients with chronic renal failure. Significantly increased kynurenine and neopterin levels
Martinsons Agris, Rudzite Vera, Widner Bernhard, Fuchs Dietmar   +3 more
doaj   +1 more source

Kynurenines in CNS disease: regulation by inflammatory cytokines

Frontiers in Neuroscience, 2014
The kynurenine pathway metabolizes the essential amino acid tryptophan and generates a number of neuroactive metabolites collectively called the kynurenines.
Brian M Campbell, Erik eCharych, Anna W Lee, Thomas eMöller   +3 more
doaj   +1 more source

Brain Kynurenine Pathway Metabolite Levels May Reflect Extent of Neuroinflammation in ALS, FTD and Early Onset AD

Pharmaceuticals, 2023
Objectives: Despite distinct clinical profiles, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients share a remarkable portion of pathological features, with a substantial percentage of patients displaying a mixed disease ...
Annelies Heylen, Yannick Vermeiren, Ido P. Kema, Martijn van Faassen, Claude van der Ley, Debby Van Dam, Peter P. De Deyn   +6 more
doaj   +1 more source

Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

Malaria Journal, 2017
Background One-fourth of children with cerebral malaria (CM) retain cognitive sequelae up to 2 years after acute disease. The kynurenine pathway of the brain, forming neuroactive metabolites, e.g.
Dag Holmberg, Elisabeth Franzén-Röhl, Richard Idro, Robert O. Opoka, Paul Bangirana, Carl M. Sellgren, Ronny Wickström, Anna Färnert, Lilly Schwieler, Göran Engberg, Chandy C. John   +10 more
doaj   +1 more source

Kynurenines and Neurofilament Light Chain in Multiple Sclerosis

Frontiers in Neuroscience, 2021
Multiple sclerosis is an autoimmune, demyelinating, and neurodegenerative disease of the central nervous system. In recent years, it has been proven that the kynurenine system plays a significant role in the development of several nervous system ...
Dániel Pukoli, Dániel Pukoli, Helga Polyák, Cecilia Rajda, László Vécsei, László Vécsei   +5 more
doaj   +1 more source

Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K+ channels

Journal of Pharmacological Sciences, 2015
Kynurenine is a potential contributor to hypotension in animal and human sepsis. The present study was designed to examine whether the voltage-dependent K+ channels encoded by the KCNQ gene family (Kv7 channels) mediate vasodilator effects of kynurenine ...
Kensuke Sakakibara, Guo-Gang Feng, Jiazheng Li, Takahiko Akahori, Yoshitaka Yasuda, Emi Nakamura, Noboru Hatakeyama, Yoshihiro Fujiwara, Hiroyuki Kinoshita   +8 more
doaj   +1 more source

Tryptophan Metabolites, Cytokines, and Fatty Acid Binding Protein 2 in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Biomedicines, 2021
Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) differ for triggers, mode of start, associated symptoms, evolution, and biochemical traits.
Manuela Simonato, Stefano Dall’Acqua, Caterina Zilli, Stefania Sut, Romano Tenconi, Nicoletta Gallo, Paolo Sfriso, Leonardo Sartori, Francesco Cavallin, Ugo Fiocco, Paola Cogo, Paolo Agostinis, Anna Aldovini, Daniela Bruttomesso, Renzo Marcolongo, Stefano Comai, Aldo Baritussio   +16 more
doaj   +1 more source