Results 11 to 20 of about 34,126 (294)

Paliperidone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways [PDF]

Frontiers in Pharmacology, 2021
Emerging evidence indicates that early-life exposure to environmental factors may increase the risk for schizophrenia via inflammatory mechanisms. Inflammation can alter the metabolism of tryptophan through the oxidative kynurenine pathway to compounds ...
Karina S. MacDowell, Karina S. MacDowell, Karina S. MacDowell, Eva Munarriz-Cuezva, Eva Munarriz-Cuezva, J. Javier Meana, J. Javier Meana, J. Javier Meana, Juan C. Leza, Juan C. Leza, Juan C. Leza, Jorge E. Ortega, Jorge E. Ortega, Jorge E. Ortega   +13 more
doaj   +2 more sources

The Role of Activation of the Tryptophan-Kynurenine Axis in the Pathogenesis of Acute Cerebrovascular Diseases: A Literature Review [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
Introduction: Acute cerebrovascular disorders are a major contributor to adult disability. The underlying processes that contribute to their development include inflammation, excitotoxicity, oxidative stress, and dysregulation of the tryptophan ...
Marina Grigolashvili, Alina Seryogina, Mira Beisembayeva, Shynar Muratbekova, Ivan Turkevich, Yelena Shayakhmetova   +5 more
doaj   +2 more sources

The kynurenine system and immunoregulation [PDF]

Journal of Neural Transmission, 2011
There is developing interest in the role of the kynurenines in the immune function. A considerable amount of evidence has accumulated as concerns interactions between the kynurenine pathway, cytokines and the nervous system. Indoleamine 2,3-dioxygenase (IDO) occupies a key position connecting the immune system and the kynurenine pathway.
Mándi Yvette, Vécsei László
openaire   +4 more sources

Cluster headache and kynurenines [PDF]

The Journal of Headache and Pain, 2023
Abstract Background The glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites derived from catabolism of tryptophan (Trp) have significant involvement not only in glutamatergic processes, but ...
Tuka Bernadett, Körtési Tamás, Nánási Nikolett, Tömösi Ferenc, Janáky Tamás, Veréb Dániel, Szok Délia, Tajti János, Vécsei László   +8 more
openaire   +4 more sources

Are Kynurenines Accomplices or Principal Villains in Dementia? Maintenance of Kynurenine Metabolism [PDF]

Molecules, 2020
Worldwide, 50 million people suffer from dementia, a group of symptoms affecting cognitive and social functions, progressing severely enough to interfere with daily life. Alzheimer’s disease (AD) accounts for most of the dementia cases. Pathological and clinical findings have led to proposing several hypotheses of AD pathogenesis, finding a presence of
Masaru Tanaka, Zsuzsanna Bohár, László Vécsei   +2 more
openaire   +5 more sources

Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease. [PDF]

PLoS ONE, 2015
The kynurenine pathway is a fundamental mechanism of immunosuppression and peripheral tolerance. It is increasingly recognized as playing a major role in the pathogenesis of a wide variety of inflammatory, neurodegenerative and malignant disorders ...
Simon P Jones, Nunzio F Franco, Bianca Varney, Gayathri Sundaram, David A Brown, Josien de Bie, Chai K Lim, Gilles J Guillemin, Bruce J Brew   +8 more
doaj   +1 more source

Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma.

PLoS ONE, 2020
BackgroundWe examined serum kynurenine levels in patients with chronic hepatitis C virus infection, and the relationship between serum kynurenine and prognosis in patients with hepatocellular carcinoma (HCC) and chronic hepatitis C.MethodsWe ...
Shigemune Bekki, Satoru Hashimoto, Kazumi Yamasaki, Atsumasa Komori, Seigo Abiru, Shinya Nagaoka, Akira Saeki, Tomoyuki Suehiro, Yuki Kugiyama, Asami Beppu, Tamotsu Kuroki, Minoru Nakamura, Masahiro Ito, Hiroshi Yatsuhashi   +13 more
doaj   +1 more source

Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial

Journal of Neuroinflammation, 2021
Background Administration of lipopolysaccharide (LPS) from Gram-negative bacteria, also known as the human endotoxemia model, is a standardized and safe model of human inflammation. Experimental studies have revealed that peripheral administration of LPS
Vincent Millischer, Matthias Heinzl, Anthi Faka, Michael Resl, Ada Trepci, Carmen Klammer, Margot Egger, Benjamin Dieplinger, Martin Clodi, Lilly Schwieler   +9 more
doaj   +1 more source

Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile [PDF]

, 2014
Tryptophan is an important precursor for chemical entities that ultimately support the biosynthesis of key metabolites. The second stage of tryptophan catabolism is catalysed by kynurenine formamidase, an enzyme that is different between eukaryotes and ...
Zoltner, Martin, Srikannathasan, Velupillai, Hunter, William N., Díaz-Sáez, Laura   +3 more
core   +1 more source

Effects of inflammation on the kynurenine pathway in schizophrenia — a systematic review

Journal of Neuroinflammation, 2020
Background In the last decade, there has been growing evidence that an interaction exists between inflammation and the kynurenine pathway in schizophrenia.
Bruno Pedraz-Petrozzi, Osama Elyamany, Christoph Rummel, Christoph Mulert   +3 more
doaj   +1 more source