The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors [PDF]
Molecules, 2022 Under normal physiological conditions, the kynurenine pathway (KP) plays a critical role in generating cellular energy and catabolizing tryptophan.
Tamera D Hughes +2 more
exaly +6 more sources
The tryptophan–kynurenine pathway in immunomodulation and cancer metastasis [PDF]
Cancer Medicine, 2023 Introduction The activation of the kynurenine pathway in cancer progression and metastasis through immunomodulatory pathways has drawn attention to the potential for kynurenine pathway inhibition.
June Cheptoo Serem +2 more
exaly +4 more sources
The Role of Activation of the Tryptophan-Kynurenine Axis in the Pathogenesis of Acute Cerebrovascular Diseases: A Literature Review [PDF]
Ķazaķstannyṇ Klinikalyķ MedicinasyIntroduction: Acute cerebrovascular disorders are a major contributor to adult disability. The underlying processes that contribute to their development include inflammation, excitotoxicity, oxidative stress, and dysregulation of the tryptophan ...
Marina Grigolashvili +5 more
doaj +3 more sources
The kynurenine system and immunoregulation [PDF]
Journal of Neural Transmission, 2011 There is developing interest in the role of the kynurenines in the immune function. A considerable amount of evidence has accumulated as concerns interactions between the kynurenine pathway, cytokines and the nervous system. Indoleamine 2,3-dioxygenase (IDO) occupies a key position connecting the immune system and the kynurenine pathway.
Mándi Yvette, Vécsei László
openaire +4 more sources
Synchronous spectrofluorimetric determination of tryptophan and kynurenine in human plasma using hydroxypropyl-β-cyclodextrin complexation for investigating their role in major depressive disorder [PDF]
Scientific ReportsMajor depressive disorder (MDD) is recently associated with immunological activation and deregulation of the kynurenine pathway, which redirects tryptophan metabolism away from serotonin production and towards neuroactive metabolites.
Adnan Alharbi +4 more
doaj +2 more sources
The kynurenine pathway: an immunometabolic bridge linking systemic inflammation to neuroaxonal vulnerability in multiple sclerosis [PDF]
Frontiers in Cellular NeuroscienceMultiple sclerosis (MS) extends beyond focal autoimmune demyelination, with progressive neurodegeneration and cognitive impairment arising from mechanisms not fully explained by inflammatory lesions alone.
José Luis Maldonado-García +9 more
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Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo
EBioMedicine, 2021 Background: L-kynurenine is a tryptophan-derived immunosuppressive metabolite and precursor to neurotoxic anthranilate and quinolinate. We evaluated the stereoisomer D-kynurenine as an immunosuppressive therapeutic which is hypothesized to produce less ...
Peter J. Siska +22 more
doaj +1 more source
Cluster headache and kynurenines [PDF]
The Journal of Headache and Pain, 2023 Abstract Background The glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites derived from catabolism of tryptophan (Trp) have significant involvement not only in glutamatergic processes, but ...
Tuka Bernadett +8 more
openaire +4 more sources
Diagnostics, 2022 Kynurenine is a tryptophan metabolite linked to several inflammatory processes including transplant failure, a significant challenge in transplant medicine. The detection of small molecules such as kynurenine, however, is often complex and time consuming.
Max Borgolte +4 more
doaj +1 more source
Scientific Reports, 2021 Inflammation increases the risk of cardiometabolic disease. Delineating specific inflammatory pathways and biomarkers of their activity could identify the mechanistic underpinnings of the increased risk. Plasma levels of kynurenine, a metabolite involved
Minoo Bagheri +16 more
doaj +1 more source