Results 11 to 20 of about 41,015 (259)

The role of kynurenine and kynurenine metabolites in psoriasis

Türk Biyokimya Dergisi
Psoriasis is a widespread immunological disease characterised by inflammation and primarily associated with skin and joint symptoms. The kynurenine pathway significantly influences inflammation and immune system activity.
Akyurek Fikret, Tuncez-Akyurek Fatma, Sengul Fatma   +2 more
doaj   +2 more sources

Targeting Kynurenine Synthesis Attenuated Cigarette Smoke-Induced COPD-Like Lung Injury Driven by TALDO1-Mediated Metabolic Reprogramming. [PDF]

Adv Sci (Weinh)
Cigarette smoke induces airway epithelial TALDO1 upregulation and L‐kynurenine accumulation, driving mitochondrial injury with elevated mtROS, reduced Δψm, ATP, and OCR. This links to lung inflammation, alveolar destruction, and lung function damage, all attenuated by Epacadostat or Taldo1 reduction.
Wang W, Wu M, Yang Y, Chen Z, Yan J, Jin X, Cui Y, Zhang F, Li H, Chen W, Zhou Y, Zhu L, Tu W, Ran P.   +13 more
europepmc   +2 more sources

Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype

, 2005
The gene coding for arylformamidase (Afmid, also known as kynurenine formamidase) was inactivated in mice through the removal of a shared bidirectional promoter region regulating expression of the Afmid and thymidine kinase (Tk) genes. Afmid/Tk-deficient
Pabarcus, Michael K., Dobrovolsky, Vasily N., Bowyer, John F., Heflich, Robert H., Williams, Lee D., Doerge, Daniel R., Bergquist, Jonas,, Casida, John E., Arvidsson, Björn,   +8 more
core   +7 more sources

Binding of L-kynurenine to X. campestris tryptophan 2,3-dioxygenase [PDF]

, 2021
The kynurenine pathway is the major route of tryptophan metabolism. The first step of this pathway is catalysed by one of two heme-dependent dioxygenase enzymes – tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) – leading initially ...
H Kwon (7106996), EL Raven (11681302), MH Jesani (11681293), J Clayden (11681296), CG Mowat (11681299), SJ Thackray (11681290), ES Booth (11681284), J Basran (7670954), LP Campbell (11681287), PCE Moody (7706810)   +9 more
core   +6 more sources

Cluster headache and kynurenines [PDF]

The Journal of Headache and Pain, 2023
Abstract Background The glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites derived from catabolism of tryptophan (Trp) have significant involvement not only in glutamatergic processes, but ...
Tuka Bernadett, Körtési Tamás, Nánási Nikolett, Tömösi Ferenc, Janáky Tamás, Veréb Dániel, Szok Délia, Tajti János, Vécsei László   +8 more
openaire   +4 more sources

Brain Versus Blood: A Systematic Review on the Concordance Between Peripheral and Central Kynurenine Pathway Measures in Psychiatric Disorders

Frontiers in Immunology, 2021
ObjectiveDisturbances in the kynurenine pathway have been implicated in the pathophysiology of psychotic and mood disorders, as well as several other psychiatric illnesses.
Katrien Skorobogatov, Katrien Skorobogatov, Livia De Picker, Livia De Picker, Robert Verkerk, Violette Coppens, Violette Coppens, Marion Leboyer, Marion Leboyer, Marion Leboyer, Marion Leboyer, Norbert Müller, Manuel Morrens, Manuel Morrens   +13 more
doaj   +1 more source

Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease. [PDF]

PLoS ONE, 2015
The kynurenine pathway is a fundamental mechanism of immunosuppression and peripheral tolerance. It is increasingly recognized as playing a major role in the pathogenesis of a wide variety of inflammatory, neurodegenerative and malignant disorders ...
Simon P Jones, Nunzio F Franco, Bianca Varney, Gayathri Sundaram, David A Brown, Josien de Bie, Chai K Lim, Gilles J Guillemin, Bruce J Brew   +8 more
doaj   +1 more source

Serum kynurenine levels are a novel biomarker to predict the prognosis of patients with hepatocellular carcinoma.

PLoS ONE, 2020
BackgroundWe examined serum kynurenine levels in patients with chronic hepatitis C virus infection, and the relationship between serum kynurenine and prognosis in patients with hepatocellular carcinoma (HCC) and chronic hepatitis C.MethodsWe ...
Shigemune Bekki, Satoru Hashimoto, Kazumi Yamasaki, Atsumasa Komori, Seigo Abiru, Shinya Nagaoka, Akira Saeki, Tomoyuki Suehiro, Yuki Kugiyama, Asami Beppu, Tamotsu Kuroki, Minoru Nakamura, Masahiro Ito, Hiroshi Yatsuhashi   +13 more
doaj   +1 more source

A systematic review and meta-analysis of the kynurenine pathway of tryptophan metabolism in rheumatic diseases

Frontiers in Immunology, 2023
There is an increasing interest in the pathophysiological role of the kynurenine pathway of tryptophan metabolism in the regulation of immune function and inflammation.
Arduino A. Mangoni, Arduino A. Mangoni, Angelo Zinellu   +2 more
doaj   +1 more source

Are Kynurenines Accomplices or Principal Villains in Dementia? Maintenance of Kynurenine Metabolism [PDF]

Molecules, 2020
Worldwide, 50 million people suffer from dementia, a group of symptoms affecting cognitive and social functions, progressing severely enough to interfere with daily life. Alzheimer’s disease (AD) accounts for most of the dementia cases. Pathological and clinical findings have led to proposing several hypotheses of AD pathogenesis, finding a presence of
Masaru Tanaka, Zsuzsanna Bohár, László Vécsei   +2 more
openaire   +5 more sources