Results 51 to 60 of about 172,741 (147)

Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells [PDF]

, 2010
Background : The immunoregulatory enzyme indoleamine 2,3-dioxygenase, which catalyzes the conversion of tryptophan into kynurenine, is expressed in a significant subset of patients with acute myeloid leukemia, resulting in the inhibition of T-cell ...
Emanuela Ottaviani, C. Evangelisti, Michele Baccarani, CURTI, ANTONIO, Roberto M Lemoli, Onofri C, Sergio Rutella, SALVESTRINI, VALENTINA, BACCARANI, MICHELE, Chiara Onofri, " L, LEMOLI, ROBERTO MASSIMO, OTTAVIANI, EMANUELA, M. Aluigi, Antonio Curti, D. Ocadlikova, Cecilia Evangelisti, V. Salvestrini, OCADLIKOVA, DARINA, Darina Ocadlikova, Raimondo De Cristofaro, M. Baccarani, TRABANELLI, SARA, R. M. Lemoli, Sara Trabanelli, ALUIGI, MICHELA, A. Curti, A Seràgnoli, S. Rutella, R. De Cristofaro, E. Ottaviani, S. Trabanelli, EVANGELISTI, CECILIA, Valentina Salvestrini, Rutella S, De Cristofaro R, C. Onofri, Michela Aluigi, Aluigi M, Curti A, Trabanelli S, Salvestrini V, Ocadlikova D, Evangelisti C, Roberto M. Lemoli, Ottaviani E, Baccarani M   +46 more
core   +1 more source

Metabolic dialogues: regulators of chimeric antigen receptor T cell function in the tumor microenvironment

Molecular Oncology, Volume 18, Issue 7, Page 1695-1718, July 2024.
T cells engineered to express chimeric antigen receptors (CAR) are dependent on the transport and utilization of nutrients from the extracellular space, fueling their anti‐tumor activity. Nonetheless, the tumor microenvironment is characterized by a dearth of several key nutrients and alterations in metabolic scavenging systems.
Josquin Moraly, Taisuke Kondo, Mehdi Benzaoui, Justyn DuSold, Sohan Talluri, Marie C. Pouzolles, Christopher Chien, Valérie Dardalhon, Naomi Taylor   +8 more
wiley   +1 more source

Modulation of indoleamine 2,3-dioxygenase by interferon-gamma in human placental chorionic villi.

, 2000
The effect of interferon-gamma on indoleamine 2,3-dioxygenase, a tryptophan catabolizing enzyme, was studied in cultured human placental chorionic villi.
Sargent, IL, Sargent, Ian, Redman, CW, Boyd, CA, Kudo, Y   +4 more
core   +1 more source

Extracellular vesicles originating from melanoma cells promote dysregulation in haematopoiesis as a component of cancer immunoediting

Journal of Extracellular Vesicles, Volume 13, Issue 7, July 2024.
Abstract Haematopoiesis dysregulation with the presence of immature myeloid and erythroid immunosuppressive cells are key characteristics of the immune escape phase of tumour development. Here, the role of in vitro generated B16F10 tumour cell‐derived extracellular vesicles (tEVs) as indirect cellular communicators, participating in tumour‐induced ...
Doste R. Mamand, Safa Bazaz, Dara K. Mohammad, Xiuming Liang, Svetlana Pavlova, Carsten Mim, Susanne Gabrielsson, Joel Z. Nordin, Oscar P. B. Wiklander, Manuchehr Abedi‐Valugerdi, Samir EL‐Andaloussi   +10 more
wiley   +1 more source

The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane

, 2014
Indoleamine-2,3-dioxygenase-1 (IDO1) is a critical immunoregulatory enzyme responsible for the metabolism of tryptophan during inflammation and disease.
Reed, John H., Ioppolo, Joseph A., Austin, Christopher J. D., Ong, Jennifer A., Kahlert, Jan, Rendina, Louis M., Issa, Fatiah, Hibbs, David, Smith, Jason R., Jamie, Joanne F.   +9 more
core   +2 more sources

Ce6 nanoassemblies: Molecular mechanism and strategies for combinational anticancer therapy

Aggregate, Volume 5, Issue 1, February 2024.
The photosensitizer chlorin e6 (Ce6) emerges as a promising option for molecular self‐assembly owing to its planar conjugated structure and hydrophobicity. The resulting self‐assembled nanoparticles exhibit enhanced pharmacokinetic profile and excellent biocompatibility.
Yuwei Liu, Shuting Xu, Qingyang Lyu, Yi Huang, Weiping Wang   +4 more
wiley   +1 more source

Indoleamine 2,3-dioxygenase vaccination

, 2015
Indoleamine 2,3-dioxygenase (IDO) is an immunoregulatory enzyme. Remarkably, we discovered IDO-specific T cells that can influence adaptive immune reactions in patients with cancer.
Svane, Inge Marie, Andersen, Mads Hald
core   +1 more source

Exploring the serotonin‐probiotics‐gut health axis: A review of current evidence and potential mechanisms

Food Science &Nutrition, Volume 12, Issue 2, Page 694-706, February 2024.
Effects of serotonin‐5HT on central nervous system & GI tract functions. Abstract Modulatory effects of serotonin (5‐Hydroxytryptamine [5‐HT]) have been seen in hepatic, neurological/psychiatric, and gastrointestinal (GI) disorders. Probiotics are live microorganisms that confer health benefits to their host.
Noor Akram, Zargham Faisal, Rushba Irfan, Yasir Abbas Shah, Syeda Ayesha Batool, Toobaa Zahid, Aqsa Zulfiqar, Areeja Fatima, Qudsia Jahan, Hira Tariq, Farhan Saeed, Aftab Ahmed, Aasma Asghar, Huda Ateeq, Muhammad Afzaal, Mahbubur Rahman Khan   +15 more
wiley   +1 more source

HIV-Induced Type I Interferon and Tryptophan Catabolism Drive T Cell Dysfunction Despite Phenotypic Activation [PDF]

, 2008
10.03.14 KB.
Shearer, GM, Hardy, AW, Anderson Stephanie A., Adriano Boasso, Shearer Gene M., Dolan, MJ, Matthew J Dolan, Boasso Adriano, Dolan Matthew J., Andrew W Hardy, Stephanie A Anderson, Gene M Shearer, Boasso, A, Hardy Andrew W., Anderson, SA   +14 more
core   +1 more source

Anti‐Inflammatory and Microbiota‐Regulating Property of Deficiency Tonic Medicines in Edible Traditional Chinese Medicine: A Promising Therapy for Depressive Disorder

Journal of Food Biochemistry, Volume 2024, Issue 1, 2024.
Depression has become the leading cause of disability worldwide. Conventional serotonergic antidepressants fail to meet anticipated outcomes and increase the risk of drug dependency and side effects. Consequently, the significance of diet and nutrition in the prevention and management of depression and anxiety has increasingly received attention.
Siyu Ren, Peilin Qin, Gang Wang, Jian Yang, Akhilesh K. Verma   +4 more
wiley   +1 more source