Results 241 to 250 of about 172,313 (331)

Ir/Ni Metallaphotoredox Catalysis for the C(sp³)─H Bond α-Arylation and Alkylation of N-Alkyl N-Heterocycles. [PDF]

Chemistry
Lv B, Ling F, Soulé JF.
europepmc   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Clade III Synthases Add Cyclic and Linear Terpenoids to the Psilocybe Metabolome

ChemBioChem, EarlyView.
The Psilocybe cubensis terpene synthases, CubB‐CubE, were investigated. Product formation assays identified CubB as a (3R,6E)‐(‐)‐nerolidol or linalool synthase, whereas CubC is a multiproduct synthase catalyzing the formation of β‐caryophyllene and other linear and cyclic sesquiterpenes/‐terpenoids.
Nick Zschoche, Sebastian Schober, Karl Walther, Andrew R. Chadeayne, Markus Gressler, Stefan Bartram, Sarah E. O’Connor, Dirk Hoffmeister   +7 more
wiley   +1 more source

Structural Basis of Regioselective Bromination of Tricyclic Tryptoline by the Tryptophan Halogenase Thal

ChemBioChem, EarlyView.
This study shows that the flavin‐dependent tryptophan halogenase Thal also regioselectively halogenates the tricyclic non‐native substrate tryptoline, a β‐carboline with various pharmacological activities. Interestingly, Thal brominates a different position of the shared pharmacophore indole in tryptoline than it does in tryptophan. A crystal structure
Simon Bork, Caroline Besse, Norbert Sewald, Hartmut H. Niemann   +3 more
wiley   +1 more source

Modulation of the Neuro-Cancer Connection by Metabolites of Gut Microbiota. [PDF]

Biomolecules
Mafe AN, Büsselberg D.
europepmc   +1 more source

Activity‐enhancing mutations in an LmrR‐based artificial metalloenzyme destabilize the protein scaffold and alter its conformational plasticity

ChemBioChem, Accepted Article.
Artificial metalloenzymes (ArM) hold great potential for the sustainable catalysis of complex new‐to‐nature reactions. To efficiently improve the catalytic efficacy of ArMs a rational approach is desirable, requiring detailed molecular insight into their conformational landscape.
Adil A. Safeer, Fabrizio Casilli, Wouter Beugelink, Gerard Roelfes, Marc Baldus, Hugo van Ingen   +5 more
wiley   +1 more source

Ruthenium(ii) catalyzed C-3 site selective alkenylation of indole derivatives via C-H activation. [PDF]

RSC Adv
Rallabandi J, Mohanty S, Shown I.
europepmc   +1 more source

A Polyproline Type II Peptidomimetic Disrupts a Grb2 SH3C Domain Protein–Protein Interaction Implicated in Breast Cancer

ChemBioChem, EarlyView.
Benzoylurea scaffolds accurately mimic the side‐chain vectors of the i, i + 1/2, and i + 3 positions of polyproline type II helices, showing functional activity in the disruption of a protein–protein interaction implicated in breast cancer. Given the essential role of protein–protein interactions (PPIs) in cellular signaling pathways, their selective ...
James Luccarelli, Philip C. Simister, Andrew D. Hamilton, Stephan M. Feller, Sam Thompson   +4 more
wiley   +1 more source

A coopetition-driven strategy of parallel/perpendicular aromatic stacking enabling metastable supramolecular polymerization. [PDF]

Nat Commun
Gao Z, Xie X, Zhang J, Yuan W, Yan H, Tian W.   +5 more
europepmc   +1 more source