Results 241 to 250 of about 172,313 (331)
Ir/Ni Metallaphotoredox Catalysis for the C(sp<sup>3</sup>)─H Bond α-Arylation and Alkylation of N-Alkyl N-Heterocycles. [PDF]
Lv B, Ling F, Soulé JF.
europepmc +1 more source
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves+3 more
wiley +1 more source
Clade III Synthases Add Cyclic and Linear Terpenoids to the Psilocybe Metabolome
The Psilocybe cubensis terpene synthases, CubB‐CubE, were investigated. Product formation assays identified CubB as a (3R,6E)‐(‐)‐nerolidol or linalool synthase, whereas CubC is a multiproduct synthase catalyzing the formation of β‐caryophyllene and other linear and cyclic sesquiterpenes/‐terpenoids.
Nick Zschoche+7 more
wiley +1 more source
This study shows that the flavin‐dependent tryptophan halogenase Thal also regioselectively halogenates the tricyclic non‐native substrate tryptoline, a β‐carboline with various pharmacological activities. Interestingly, Thal brominates a different position of the shared pharmacophore indole in tryptoline than it does in tryptophan. A crystal structure
Simon Bork+3 more
wiley +1 more source
Modulation of the Neuro-Cancer Connection by Metabolites of Gut Microbiota. [PDF]
Mafe AN, Büsselberg D.
europepmc +1 more source
Artificial metalloenzymes (ArM) hold great potential for the sustainable catalysis of complex new‐to‐nature reactions. To efficiently improve the catalytic efficacy of ArMs a rational approach is desirable, requiring detailed molecular insight into their conformational landscape.
Adil A. Safeer+5 more
wiley +1 more source
Ruthenium(ii) catalyzed C-3 site selective alkenylation of indole derivatives via C-H activation. [PDF]
Rallabandi J, Mohanty S, Shown I.
europepmc +1 more source
Benzoylurea scaffolds accurately mimic the side‐chain vectors of the i, i + 1/2, and i + 3 positions of polyproline type II helices, showing functional activity in the disruption of a protein–protein interaction implicated in breast cancer. Given the essential role of protein–protein interactions (PPIs) in cellular signaling pathways, their selective ...
James Luccarelli+4 more
wiley +1 more source
A coopetition-driven strategy of parallel/perpendicular aromatic stacking enabling metastable supramolecular polymerization. [PDF]
Gao Z+5 more
europepmc +1 more source