Results 101 to 110 of about 19,750,469 (329)
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang+2 more
wiley +1 more source
Practical considerations for postarrest targeted temperature management
Out-of-hospital cardiac arrest remains a major challenge worldwide, with survival to discharge rates of
Isabelle Mullen, Benjamin S Abella
doaj +1 more source
When pulled along the axis, double-strand DNA undergoes a large conformational change and elongates roughly twice its initial contour length at a pulling force about 70 pN.
Maiti, Prabal K, Santosh, Mogurampelly
core +1 more source
A stepwise emergence of evolution in the RNA world
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
High-speed gas-solid two-phase flow erosion of 1Cr9Mo alloy
A self-made gas-solid erosion testing apparatus driven by shock wave was used to investigate the wear properties of 1Cr9Mo steel commonly used as manufacturing materials in the coal chemical industry, and SiO2, Al2O3 and SiC particles were chosen as ...
OU Guo-fu+4 more
doaj +1 more source
Brucella NyxA and NyxB dimerization enhances effector function during infection
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre+4 more
wiley +1 more source
Background Sepsis is the leading cause of mortality for critically ill patients worldwide. Patients develop T lymphocyte dysfunctions leading to T-cell exhaustion associated with increased risk of death.
Julie Mouillaux+10 more
doaj +1 more source
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro+2 more
wiley +1 more source
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt+4 more
wiley +1 more source
Disorder-induced superfluidity
We use quantum Monte Carlo simulations to study the phase diagram of hard-core bosons with short-ranged {\it attractive} interactions, in the presence of uniform diagonal disorder.
Lode Pollet+3 more
core +1 more source