Results 51 to 60 of about 4,122,423 (255)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Semiglobal Matching Results on the ISPRS Stereo Matching Benchmark [PDF]
, 2011 Digital surface models can be efficiently generated with automatic image matching from optical stereo images. The Working Group 4 of Commission I on "Geometric and Radiometric Modelling of Optical Spaceborne Sensors" provides a matching benchmark ...
Reinartz, Peter +3 more
core +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
On the Induced Matching Problem [PDF]
, 2007 We study extremal questions on induced matchings in certain natural graph classes. We argue that these questions should be asked for twinless graphs, that is graphs not containing two vertices with the same neighborhood.
Iyad Kanj +7 more
core +1 more source
Response to Comments: Kansas Induced Seismicity Action Plan [2014]
, 2014 Kansas Induced Seismicity State Task Force.Induced seismicity--Kansas.Earthquakes--Kansas."The Kansas Task Force on Induced Seismicity recently closed an open comment period in response to its draft State Action Plan (SAP).
Kansas Induced Seismicity State Task Force.
core +1 more source
Maximal Induced Matchings in Triangle-Free Graphs [PDF]
, 2014 17 ...
Manu Basavaraju +4 more
openaire +4 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Putting Context into Schema Matching [PDF]
, 2006 Attribute-level schema matching has proven to be an important first step in developing mappings for data exchange, integration, restructuring and schema evolution. In this paper we investigate contextual schema matching, in which selection conditions are
Elnahrawy, Eiman +3 more
core