Results 31 to 40 of about 4,733,094 (302)
Gene mutations and expression in breast cancer [PDF]
, 2000 Bibliography: leaves 163-190.Breast cancer is the most common cause of death amongst women, with the incidence of the disease varying between countries. Like all other cancers, breast cancer is a multigenic disorder with mutations in oncogenes and tumour
Donninger, Howard
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Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins [PDF]
, 1993 The tumor suppressor p53 exerts important protective functions towards DNA-damaging agents. Its inactivation by allelic deletions or point mutations within the P53 gene as well as complex formation of wildtype p53 with cellular or viral proteins is a ...
Caselmann, Wolfgang H. +1 more
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Aminoglycoside induced ototoxicity associated with mitochondrial DNA mutations
Egyptian Journal of Medical Human Genetics, 2016 Despite the risk of permanent ototoxic effects, aminoglycosides remain commonly utilized antibiotics worldwide due to low cost and efficiency in treating severe infections. Over the last two decades, mitochondrial mutations have been shown to enhance the
Joseph Foster II, Mustafa Tekin
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Mu-seq: sequence-based mapping and identification of transposon induced mutations. [PDF]
PLoS ONE, 2013 Mutations tagged by transposon insertions can be readily mapped and identified in organisms with sequenced genomes. Collections of such mutants allow a systematic analysis of gene function, and can be sequence-indexed to build invaluable resources.
Donald R McCarty +6 more
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RIPCAL: a tool for alignment-based analysis of repeat-induced point mutations in fungal genomic sequences [PDF]
, 2008 Background Repeat-induced point mutation (RIP) is a fungal-specific genome defence mechanism that alters the sequences of repetitive DNA, thereby inactivating coding genes.
Hane, J. +7 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Next‐generation sequencing (NGS) has emerged as a promising approach to improve diagnostic accuracy, but its feasibility in low‐ and middle‐income countries remains unknown. This study characterized the diagnostic landscape and assessed organizational readiness for NGS implementation at two childhood cancer treatment centers in Accra ...
Melissa Carvalho +6 more
wiley +1 more source
Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability [PDF]
, 2015 This work has been supported by: Motor Neurone Disease Association (G.B.M., S.C. and C.E.S.); Euan MacDonald Centre (G.B.M. and S.C.); European Research Council (L.V.); Cambridge Hospitals National Institute for Health Research Biomedical Research Center
Foster, Joshua D. +15 more
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Induction of genetic variability in okra [Abelmoschus esculentus (L.) Moench] by gamma and ems. [PDF]
Electronic Journal of Plant Breeding, 2014 An investigation was carried out to study the extent of genetic variability induced through physical and chemical mutagens in okra. Seeds of two popular okra varieties viz.
Peddi Sudharshan Reddy, L. K. Dhaduk
doaj
Mitochondrial DNA Mutations Induced by Carbon Ions Radiation: A Preliminary Study
Dose-Response, 2018 Heavy-ion irradiation-induced nuclear DNA damage and mutations have been studied comprehensively. However, there is no information about the deleterious effect of heavy-ion irradiation on mitochondrial DNA (mtDNA).
Yong Chen, Haining Gao, Wenling Ye
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