Impacts of RNA Mobility Signals on Virus Induced Somatic and Germline Gene Editing
Frontiers in Genome Editing, 2022 Viral vectors are being engineered to deliver CRISPR/Cas9 components systemically in plants to induce somatic or heritable site-specific mutations. It is hypothesized that RNA mobility signals facilitate entry of viruses or single guide RNAs (sgRNAs ...
Bliss M. Beernink +3 more
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A PCR based protocol for detecting indel mutations induced by TALENs and CRISPR/Cas9 in zebrafish. [PDF]
PLoS ONE, 2014 Genome editing techniques such as the zinc-finger nucleases (ZFNs), transcription activator-like effecter nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system Cas9 can induce efficient ...
Chuan Yu +3 more
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The bioenergetic status relates to dopamine neuron loss in familial PD with PINK1 mutations [PDF]
, 2012 Mutations in the PINK1 gene cause autosomal recessive familial Parkinson’s disease (PD). The gene encodes a mitochondrial protein kinase that plays an important role in maintaining mitochondrial function and integrity.
Johann Hagenah +39 more
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Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor [PDF]
, 2007 More than 70 missense mutations have been identified in the human melanocortin 4 receptor (MC4R), and many of them have been associated with obesity. In a number of cases, the causal link between mutations in MC4R and obesity is controversially discussed.
Stäubert, Claudia +17 more
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TILLING to detect induced mutations in soybean
BMC Plant Biology, 2008 Background Soybean (Glycine max L. Merr.) is an important nitrogen-fixing crop that provides much of the world's protein and oil. However, the available tools for investigation of soybean gene function are limited.
Nielsen Niels +13 more
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Mutagenic potency of MMS-induced 1meA/3meC lesions in E. coli. [PDF]
, 2009 The mutagenic activity of MMS in E. coli depends on the susceptibility of DNA bases to methylation and their repair by cellular defense systems. Among the lesions in methylated DNA is 1meA/3meC, which is recently recognized as being mutagenic.
Janion, Celina +7 more
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Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization [PDF]
, 2012 Carpenter syndrome is an autosomal-recessive multiple-congenital-malformation disorder characterized by multisuture craniosynostosis and polysyndactyly of the hands and feet; many other clinical features occur, and the most frequent include obesity ...
Gileadi, Opher +45 more
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K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder [PDF]
, 2011 The human fibroblast growth factor receptor 3 (FGFR3) gene is frequently mutated in superficial urothelial cell carcinoma (UCC). To test the functional significance of FGFR3 activating mutations as a ‘driver’ of UCC, we targeted the expression of mutated
Taketo, M.M. +17 more
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Mitochondrial Mutations in Ethambutol-Induced Optic Neuropathy
Frontiers in Cell and Developmental Biology, 2021 Background: Ethambutol-induced optic neuropathy (EON) is a well-recognized ocular complication in patients who take ethambutol as a tuberculosis treatment. The aim of the current study was to investigate the presence of mitochondrial mutations, including
Xiao-Hui Zhang +8 more
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Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations [PDF]
, 2010 Mutations of mitochondrial DNA are associated with a wide spectrum of disorders, primarily affecting the central nervous system and muscle function. The specific consequences of mitochondrial DNA mutations for neuronal pathophysiology are not understood.
Turnbull, Douglass M. +16 more
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