Results 21 to 30 of about 807,076 (263)
Mitochondrial Mutations in Ethambutol-Induced Optic Neuropathy
Frontiers in Cell and Developmental Biology, 2021 Background: Ethambutol-induced optic neuropathy (EON) is a well-recognized ocular complication in patients who take ethambutol as a tuberculosis treatment. The aim of the current study was to investigate the presence of mitochondrial mutations, including
Xiao-Hui Zhang +8 more
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Mu-seq: sequence-based mapping and identification of transposon induced mutations. [PDF]
PLoS ONE, 2013 Mutations tagged by transposon insertions can be readily mapped and identified in organisms with sequenced genomes. Collections of such mutants allow a systematic analysis of gene function, and can be sequence-indexed to build invaluable resources.
Donald R McCarty +6 more
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Aminoglycoside induced ototoxicity associated with mitochondrial DNA mutations
Egyptian Journal of Medical Human Genetics, 2016 Despite the risk of permanent ototoxic effects, aminoglycosides remain commonly utilized antibiotics worldwide due to low cost and efficiency in treating severe infections. Over the last two decades, mitochondrial mutations have been shown to enhance the
Joseph Foster II, Mustafa Tekin
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Mitochondrial DNA mutations associated with aminoglycoside induced ototoxicity
Journal of Otology, 2017 Aminoglycosides (AmAn) are widely used for their great efficiency against gram-negative bacterial infections. However, they can also induce ototoxic hearing loss, which has affected millions of people around the world. As previously reported, individuals
Zewen Gao, Ye Chen, Min-Xin Guan
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Cell Reports, 2020 Summary: Somatic mutations in skin cancers and other ultraviolet (UV)-exposed cells are typified by C>T and CC>TT substitutions at dipyrimidine sequences; however, many oncogenic “driver” mutations in melanoma do not fit this UV signature.
Marian F. Laughery +12 more
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Induction of genetic variability in okra [Abelmoschus esculentus (L.) Moench] by gamma and ems. [PDF]
Electronic Journal of Plant Breeding, 2014 An investigation was carried out to study the extent of genetic variability induced through physical and chemical mutagens in okra. Seeds of two popular okra varieties viz.
Peddi Sudharshan Reddy, L. K. Dhaduk
doaj
Mitochondrial DNA Mutations Induced by Carbon Ions Radiation: A Preliminary Study
Dose-Response, 2018 Heavy-ion irradiation-induced nuclear DNA damage and mutations have been studied comprehensively. However, there is no information about the deleterious effect of heavy-ion irradiation on mitochondrial DNA (mtDNA).
Yong Chen, Haining Gao, Wenling Ye
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A molecular analysis of mutations at the complex dumpy locus in Drosophila melanogaster. [PDF]
PLoS ONE, 2010 The Drosophila dumpy gene consists of seventy eight coding exons and encodes a huge extracellular matrix protein containing large numbers of epidermal growth factor-like (EGF) modules and a novel module called dumpy (DPY).
Amber Carmon +4 more
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Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle +5 more
wiley +1 more source
Inflammation-induced cell proliferation potentiates DNA damage-induced mutations in vivo.
PLoS Genetics, 2015 Mutations are a critical driver of cancer initiation. While extensive studies have focused on exposure-induced mutations, few studies have explored the importance of tissue physiology as a modulator of mutation susceptibility in vivo.
Orsolya Kiraly +4 more
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