Results 41 to 50 of about 4,733,094 (302)
Mitochondrial DNA mutations associated with aminoglycoside induced ototoxicity
Journal of Otology, 2017 Aminoglycosides (AmAn) are widely used for their great efficiency against gram-negative bacterial infections. However, they can also induce ototoxic hearing loss, which has affected millions of people around the world. As previously reported, individuals
Zewen Gao, Ye Chen, Min-Xin Guan
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A molecular analysis of mutations at the complex dumpy locus in Drosophila melanogaster. [PDF]
PLoS ONE, 2010 The Drosophila dumpy gene consists of seventy eight coding exons and encodes a huge extracellular matrix protein containing large numbers of epidermal growth factor-like (EGF) modules and a novel module called dumpy (DPY).
Amber Carmon +4 more
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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Inflammation-induced cell proliferation potentiates DNA damage-induced mutations in vivo.
PLoS Genetics, 2015 Mutations are a critical driver of cancer initiation. While extensive studies have focused on exposure-induced mutations, few studies have explored the importance of tissue physiology as a modulator of mutation susceptibility in vivo.
Orsolya Kiraly +4 more
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Cell Reports, 2020 Summary: Somatic mutations in skin cancers and other ultraviolet (UV)-exposed cells are typified by C>T and CC>TT substitutions at dipyrimidine sequences; however, many oncogenic “driver” mutations in melanoma do not fit this UV signature.
Marian F. Laughery +12 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Development of Sorghum Tolerant to Acid Soil Using Induced Mutation with Gamma Irradiation
Atom Indonesia, 2010 Water scarcity still becomes a problem in some dryland agricultural areas in Indonesia. Development of dryland farming system may be focused on crops that are required less water such as sorghum.
S. Human +3 more
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Microbiology Spectrum, 2023 The 2022 World Health Organization guidelines recommend use of two core anti-tuberculosis (TB) drugs, bedaquiline (BDQ) and clofazimine (CFZ), for treatment of drug-resistant (DR)-TB.
Jin Shi +10 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2014 Announcement -- Agenda -- Breakout Sessions: Questions and Responses -- An Ounce of Understanding is Worth a Pound of Cure / by Kyle E. Murray -- Induced Seismicity and the Oil and Gas Industry -- Overview of Kansas Earthquakes / Rick Miller, Shelby ...
Induced Seismicity State Task Force Meeting (2014 : Wichita, Kan.)
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