Results 61 to 70 of about 4,733,094 (302)

Peanut allergy:effect of environmental peanut exposure in children with filaggrin loss-of-function mutations [PDF]

, 2014
BackgroundFilaggrin (FLG) loss-of-function mutations lead to an impaired skin barrier associated with peanut allergy. Household peanut consumption is associated with peanut allergy, and peanut allergen in household dust correlates with household peanut ...
Makinson, Kerry, Hankinson, Jenny, Brown, Sara, Adnan Custovic, Nicolaos Nicolaou, McLean, W.H. Irwin, Simpson, Angela, Stephens, Alick C, Nicolaou, Nicolaos, Abdel Douiri, Simpson, Angela; id_orcid, Belgrave, Danielle C M, Kerry Makinson, Helen A. Brough, McLean, W. H. Irwin, Stephens, Alick C., Sara Brown, Brough, Helen A., Alick C. Stephens, Penagos, Martin, Turcanu, Victor, Danielle C.M. Belgrave, Lack, Gideon, Victor Turcanu, Custovic, Adnan, Belgrave, Danielle C. M., Martin Penagos, Jenny Hankinson, Gideon Lack, W.H. Irwin McLean, Brough, Helen A.; id_orcid, Belgrave, Danielle C.M., Douiri, Abdel; id_orcid, McLean, W H Irwin, Douiri, Abdel, Brough, Helen A, Angela Simpson   +36 more
core   +1 more source

Genomic saturation mutagenesis and polygenic analysis identify novel yeast genes affecting ethyl acetate production, a non-selectable polygenic trait

Microbial Cell, 2016
Isolation of mutants in populations of microorganisms has been a valuable tool in experimental genetics for decades. The main disadvantage, however, is the inability of isolating mutants in non-selectable polygenic traits.
Tom Den Abt, Ben Souffriau, Maria R. Foulquié-Moreno, Jorge Duitama, Johan M. Thevelein   +4 more
doaj   +1 more source

Antimutagenic effect of essential oil of sage (Salvia officinalis L.) and its fractions against UV-induced mutations in bacterial and yeast cells [PDF]

Archives of Biological Sciences, 2005
The inhibition of spontaneous and UV-induced mutations by essential oil (EO) of sage (Salvia officinalis L.) and its fractions F1-F5 containing different proportions of mono- and sesquiterpenes was studied with the Salmonella/microsome, E.
Knežević-Vukčević Jelena B., Vuković-Gačić Branka S., Stević Tatjana, Stanojević Jasna, Nikolić Biljana, Simić Draga   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Congenital hypogonadotropic hypogonadism due to GnRH receptor mutations in three brothers reveal sites affecting conformation and coupling [PDF]

, 2012
Congenital hypogonadotropic hypogonadism (CHH) is characterized by low gonadotropins and failure to progress normally through puberty. Mutations in the gene encoding the GnRH receptor (GNRHR1) result in CHH when present as compound heterozygous or ...
Newton, Claire, Young, Jacques, Claire L Newton, Millar, Robert, Newton, Claire L., Guiochon-Mantel Anne, Young Jacques, Guiochon-Mantel, Anne, Millar, Robert P., Bouligand, Jerome, Newton Claire L., Millar, Robert P, Tello Javier A., Tello, Javier, Anne Guiochon-Mantel, Newton, Claire L, Tello, Javier A., Millar Robert P., Robert P Millar, Jerome Bouligand, Jacques Young, Bouligand Jerome, Tello, Javier A, Javier A Tello   +23 more
core   +2 more sources

The negligible mutagenic effects of norfloxacin on the genome of the fission yeast Schizosaccharomyces pombe ATCC-16979

Microbiology Spectrum
Antibiotic therapy is commonly used in various medical scenarios, and some antibiotics will stay in the blood serum for days. Previous studies have demonstrated that the fluoroquinolone antibiotic norfloxacin exerts mutagenic effects on the whole genomes
Tongtong Lin, Xiaolin Wu, Yelin Lan, Yongchun Huang, Ziguang Deng, Yu Zhang, Michael Lynch, Hongan Long, Jiao Pan   +8 more
doaj   +1 more source

Discovery of chemically induced mutations in rice by TILLING

BMC Plant Biology, 2007
Background Rice is both a food source for a majority of the world's population and an important model system. Available functional genomics resources include targeted insertion mutagenesis and transgenic tools.
Colowit Peter, Tai Thomas H, Cooper Jennifer, Till Bradley J, Greene Elizabeth A, Henikoff Steven, Comai Luca   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Molecular dynamics as an approach to study prion protein misfolding and the effect of pathogenic mutations [PDF]

, 2011
Computer simulation of protein dynamics offers unique high-resolution information that complements experiment. Using experimentally derived structures of the natively folded prion protein (PrP), physically realistic dynamics and conformational changes ...
Valerie Daggett, Daggett, Valerie, van der Kamp, Marc W, Marc W. van der Kamp   +3 more
core   +1 more source