Results 81 to 90 of about 10,022,913 (342)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

Cell, 2021
Summary The race to produce vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began when the first sequence was published, and this forms the basis for vaccines currently deployed globally.
Daming Zhou, W. Dejnirattisai, P. Supasa, Chang Liu, A. Mentzer, H. Ginn, Yuguang Zhao, Helen M. E. Duyvesteyn, A. Tuekprakhon, Rungtiwa Nutalai, Beibei Wang, G. Paesen, C. López-Camacho, J. Slon-Campos, B. Hallis, N. Coombes, K. Bewley, S. Charlton, T. Walter, D. Skelly, S. Lumley, C. Dold, R. Levin, T. Dong, A. Pollard, J. Knight, D. Crook, T. Lambe, E. Clutterbuck, S. Bibi, A. Flaxman, M. Bittaye, Sandra Belij-Rammerstorfer, S. Gilbert, W. James, M. Carroll, P. Klenerman, E. Barnes, S. Dunachie, E. Fry, J. Mongkolsapaya, Jingshan Ren, D. Stuart, G. Screaton   +43 more
semanticscholar   +1 more source

How conformational changes can affect catalysis, inhibition and drug resistance of enzymes with induced-fit binding mechanism such as the HIV-1 protease

, 2013
A central question is how the conformational changes of proteins affect their function and the inhibition of this function by drug molecules. Many enzymes change from an open to a closed conformation upon binding of substrate or inhibitor molecules ...
Hemmateenejad, Bahram, Weikl, Thomas R.
core   +1 more source

Common Mitochondrial DNA Mutations Generated through DNA-Mediated Charge Transport [PDF]

, 2009
Mutation sites that arise in human mitochondrial DNA as a result of oxidation by a rhodium photooxidant have been identified. HeLa cells were incubated with [Rh(phi)2bpy]Cl3 (phi is 9,10-phenanthrenequinone diimine), an intercalating photooxidant, to ...
Barton, Jacqueline K., Davis, Molly L., Merino, Edward J.   +2 more
core   +2 more sources

BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations. [PDF]

PLoS Medicine, 2007
Epidermal growth factor receptor (EGFR) mutations are present in the majority of patients with non-small cell lung cancer (NSCLC) responsive to the EGFR tyrosine kinase inhibitors (TKIs) gefitinib or erlotinib.
Daniel B Costa, Balázs Halmos, Amit Kumar, Susan T Schumer, Mark S Huberman, Titus J Boggon, Daniel G Tenen, Susumu Kobayashi   +7 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

medRxiv, 2021
Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies.
W. Garcia-Beltran, Evan C. Lam, K. S. Denis, Adam D Nitido, Zeidy H. Garcia, B. Hauser, J. Feldman, Maia N Pavlovic, D. Gregory, M. Poznansky, A. Sigal, A. Schmidt, A. Iafrate, V. Naranbhai, A. Balazs   +14 more
semanticscholar   +1 more source

Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy. [PDF]

, 2014
Contraction in the mammalian heart is controlled by the intracellular Ca2+ concentration as it is in all striated muscle, but the heart has an additional signalling system that comes into play to increase heart rate and cardiac output during exercise or ...
Marston, SB, Messer, AE
core   +2 more sources

Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila

Cell Reports, 2021
Summary: The maintenance of mitochondrial homeostasis requires PTEN-induced kinase 1 (PINK1)-dependent mitophagy, and mutations in PINK1 are associated with Parkinson’s disease (PD). PINK1 is also downregulated in tumor cells with PTEN mutations. However,
Yongchao Han, Na Zhuang, Tao Wang
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source