Results 301 to 310 of about 390,247 (379)

Unravelling axonal transcriptional landscapes: insights from induced pluripotent stem cell-derived cortical neurons and implications for motor neuron degeneration. [PDF]

Open Biol
Xu J, Hörner M, Nagel M, Perhat P, Korneck M, Noß M, Hauser S, Schoels L, Admard J, Casadei N, Schuele R.   +10 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Effects of Induced Pluripotent Stem Cell-Derived Astrocytes on Cisplatin Sensitivity in Pediatric Brain Cancer Cells. [PDF]

Cancers (Basel)
Kiran S, Xue Y, Sarker DB, Sang QA.
europepmc   +1 more source

FABP7 Expression Modulates the Response of Astrocytes to Induced Endotoxemia

Glia, EarlyView.
FABP7 silencing reduces inflammatory response in astrocytes. FABP7 silencing decreases astrocyte‐mediated neurotoxicity. FABP7 silencing attenuates NF‐κB‐dependent transcriptional response during endotoxemia. ABSTRACT Fatty acid binding proteins (FABPs) are a family of small proteins involved in fatty acid (FA) subcellular trafficking.
Mariana Bresque, Daniel Esteve, Garret Balmer, Haylee L. Hamilton, Joshua S. Stephany, Mariana Pehar, Marcelo R. Vargas   +6 more
wiley   +1 more source

Generation of two induced pluripotent stem cell lines to model and investigate diseases affecting Pacific Islanders. [PDF]

Stem Cell Res
Zhang A, Jahng JWS, Guevara JV, Yan CD, McConnell MV, Wu JC.   +5 more
europepmc   +1 more source

Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application

Stem Cell Reports, 2014
H. Kamao, M. Mandai, S. Okamoto, Noriko Sakai, Akiko Suga, S. Sugita, J. Kiryu, Masayo Takahashi   +7 more
semanticscholar   +1 more source

Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation

Glia, EarlyView.
ABSTRACT Multiple sclerosis (MS) is the most common non‐infectious inflammatory CNS disease, characterized by progressive neurodegeneration and focal demyelinated lesions. Traditionally considered an autoimmune disease, MS is driven by the immune system's attack on CNS myelin, resulting in cumulative disability.
Volker Siffrin
wiley   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Human induced pluripotent stem cell-cardiomyocytes for cardiotoxicity assessment: a comparative study of arrhythmiainducing drugs with multi-electrode array analysis. [PDF]

Korean J Physiol Pharmacol
Park NK, Park YG, Choi JH, Choi HK, Moon SH, Park SJ, Choi SW.   +6 more
europepmc   +1 more source

Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration

International Journal of Cancer, EarlyView.
What's New? SOX2 is one of the key developmental genes with a reported altered expression in many tumors. The mechanisms underlying SOX2 regulation in cancer, however, remain elusive. This study shows that TP53 transcriptionally regulates SOX2 through binding to its promoter and the SRR2 enhancer.
Patricia Lado‐Fernández, Jéssica M. Vilas, Tânia Fernandes, Carmen Carneiro, Sabela Da Silva‐Álvarez, Valentín Estévez‐Souto, Pablo Pedrosa, Miguel González‐Barcia, Luis E. Abatti, Jennifer A. Mitchell, Carmen Rivas, Gema Moreno‐Bueno, Anxo Vidal, Manuel Collado   +13 more
wiley   +1 more source