Results 341 to 350 of about 390,247 (379)

Mitochondrial transfer as a novel therapeutic approach in ischemic stroke treatment: Current challenges and future perspectives

Neuroprotection, EarlyView.
Cerebral ischemia is a serious neurological disease that mainly leads to pathological changes such as mitochondrial dysfunction, oxidative stress and iron death. Mitochondria play a key role in the regulation of cellular energy metabolism and oxidative stress, and their damage can lead to mitochondrial damage, reduced adenosine triphosphate production,
Shuchen Meng, Min Bai, Changsheng Ma, Bo Han, Mengyuan Duan, Liying Zhang, Jinfen Guo, Changku Shi, Ke Li, Maotao He   +9 more
wiley   +1 more source

Induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) inhibit M1 macrophage polarization and reduce alveolar bone loss associated with periodontitis. [PDF]

Stem Cell Res Ther
Chen L, Liu Y, Yu C, Cao P, Ma Y, Geng Y, Cai Y, Zhang Y, Liu J, Li Y, Luan Q.   +10 more
europepmc   +1 more source

Plasticity of Gene Expression in Spaceflight and Postflight in Relation to Cardiovascular Disease: Mechanisms and Candidate Repurposed Drugs

PROTEOMICS, EarlyView.
ABSTRACT Spaceflight poses unique challenges to human health due to exposure to increased levels of cosmic radiation, microgravity, and associated oxidative stress. These environmental factors can lead to cellular damage, inflammation, and a range of health complications, including cardiovascular problems, immune system impairment, and an increased ...
Marilena M. Bourdakou, Eleni M. Loizidou, George M. Spyrou   +2 more
wiley   +1 more source

Microfluidic Flow Promotes a Steatotic Phenotype in Induced Pluripotent Stem Cell-Derived Hepatocytes that is Influenced by Disease State of the Donor. [PDF]

Gastro Hep Adv
Minocha E, Jiang L, Gupta AK, Green RM, Zohar Y, Wertheim JA.   +5 more
europepmc   +1 more source

Pancreatic islet composites secrete insulin in response to a glucose challenge [PDF]

, 2017
Black Jr., Asa C, Cope, Lee Anne, Limnios, Jason Ionnis, Lochner, Frank, McCommon, George, Young, Henry E.   +5 more
core  

Microglial Drivers of Alzheimer's Disease Pathology: An Evolution of Diverse Participating States

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Microglia, the resident immune‐competent cells of the brain, become dysfunctional in Alzheimer's disease (AD), and their aberrant immune responses contribute to the accumulation of pathological proteins and neuronal injury. Genetic studies implicate microglia in the development of AD, prompting interest in developing immunomodulatory therapies
Madison K. Kuhn, Elizabeth A. Proctor
wiley   +1 more source

Simulation of cardiac arrhythmias in human induced pluripotent stem cell-derived cardiomyocytes. [PDF]

PLoS One
Bommer T, Knierim M, Unsöld J, Riedl D, Stengel L, Paulus M, Körtl T, Liaw N, Maier LS, Streckfuss-Bömeke K, Sossalla S, Pabel S.   +11 more
europepmc   +1 more source

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Preclinical Cardiotoxicity Screening in Cardio-Oncology. [PDF]

JACC CardioOncol
Shead KD, Huethorst E, Burton F, Lang NN, Myles RC, Smith GL.   +5 more
europepmc   +1 more source

Cryomicroneedle Arrays for Biotherapeutics Delivery

Small Science, EarlyView.
CryoMNs for biotherapeutic delivery to treat various diseases. CryoMNs: cryomicroneedles. Biotherapy offers a promising approach for treating a variety of diseases. However, the lack of advanced delivery systems remains a significant barrier to improve the efficacy, safety, and cost‐effectiveness of biotherapeutics.
Chunli Yang, Li Zhang, Angxi Zhou, Siyi Wang, Ya Ren, Maya Xiang, Run Tian, Yang Yu, Rong Li, Maling Gou   +9 more
wiley   +1 more source