Results 51 to 60 of about 216,890 (260)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Electrical resistivity and induced polarization in the investigation of acid drainage in decommissioning a mine

REM: International Engineering Journal
The opening and development of mines without previous planning can generate costly environmental liabilities that are difficult to recover. The Osamu Utsumi Mine was responsible for extracting uranium until 1995 in open pit mining operations. The sulfide
Beatriz Guzzo Duz, César Augusto Moreira, Marcos Eduardo Hartwig, Felipe Queiroz Miano, Lucas Moreira Furlan   +4 more
doaj   +1 more source

Microglia polarization in heat-induced early neural injury

Archives of Medical Science, 2021
Introduction In the occurrence and development of heat stroke (HS), factors such as hyperthermia, ischemia and hypoxia are essential to the central nervous system (CNS) inflammatory response, but the main mechanism underlying CNS inflammation remains ...
Lei Wang, Jing Zhao, Baofeng Zhu, Junhua Shen, Zi Ye, Qiang Peng, Yi Zhang   +6 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A geophysical study of a coastal plane in Sardinia

Annals of Geophysics, 1996
The paper deals with some aspects of the planning and the interpretation of the IP and resistivity measurements in the San Priamo coastal plane (Sardinia, Italy).
A. Godio, L. Ferrero, G. Ranieri
doaj   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Polarization-maintaining terahertz anti-resonant fibers based on mode couplings between core and cladding

Results in Physics, 2021
This study numerically investigated the index-induced mode coupling between the fundamental mode in core and the fundamental mode in cladding tubes in THz anti-resonant fibers (ARFs), and then, this index-induced mode coupling was applied for designing ...
Shuai Sun, Wei Shi, Quan Sheng, Zhongbao Yan, Shuai Zhang, Junxiang Zhang, Chaodu Shi, Guizhong Zhang, Jianquan Yao   +8 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Permeability and Induced Polarization of Mudstones

Water Resources Research
Electrical measurements can be used to estimate hydraulic properties such as permeability (k) in sedimentary rocks. Previous work has focused on sandstones, siltstones, and carbonates, while investigations on mudstones have rarely been reported.
Klaudio Peshtani, Andreas Weller, Lee Slater   +2 more
doaj   +1 more source

Geophysics‐Based Contaminant Mass Discharge Quantification Downgradient of a Landfill and a Former Pharmaceutical Factory

Water Resources Research, 2018
Contaminant mass discharge is a commonly applied tool to evaluate the environmental impact of contaminated sites on water resources. At large contaminated sites with heterogeneous sources, such as landfills, the number of wells available is often not ...
Nicola Balbarini, Vinni Rønde, Pradip Maurya, Gianluca Fiandaca, Ingelise Møller, Knud Erik Klint, Anders V. Christiansen, Philip J. Binning, Poul L. Bjerg   +8 more
doaj   +1 more source