Results 61 to 70 of about 259,340 (309)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

A geophysical study of a coastal plane in Sardinia

Annals of Geophysics, 1996
The paper deals with some aspects of the planning and the interpretation of the IP and resistivity measurements in the San Priamo coastal plane (Sardinia, Italy).
A. Godio, L. Ferrero, G. Ranieri
doaj   +1 more source

Microglia polarization in heat-induced early neural injury

Archives of Medical Science, 2021
Introduction In the occurrence and development of heat stroke (HS), factors such as hyperthermia, ischemia and hypoxia are essential to the central nervous system (CNS) inflammatory response, but the main mechanism underlying CNS inflammation remains ...
Lei Wang, Jing Zhao, Baofeng Zhu, Junhua Shen, Zi Ye, Qiang Peng, Yi Zhang   +6 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Permeability and Induced Polarization of Mudstones

Water Resources Research
Electrical measurements can be used to estimate hydraulic properties such as permeability (k) in sedimentary rocks. Previous work has focused on sandstones, siltstones, and carbonates, while investigations on mudstones have rarely been reported.
Klaudio Peshtani, Andreas Weller, Lee Slater   +2 more
doaj   +1 more source

Geophysics‐Based Contaminant Mass Discharge Quantification Downgradient of a Landfill and a Former Pharmaceutical Factory

Water Resources Research, 2018
Contaminant mass discharge is a commonly applied tool to evaluate the environmental impact of contaminated sites on water resources. At large contaminated sites with heterogeneous sources, such as landfills, the number of wells available is often not ...
Nicola Balbarini, Vinni Rønde, Pradip Maurya, Gianluca Fiandaca, Ingelise Møller, Knud Erik Klint, Anders V. Christiansen, Philip J. Binning, Poul L. Bjerg   +8 more
doaj   +1 more source

High-temperature electromagnons in the magnetically induced multiferroic cupric oxide driven by intersublattice exchange [PDF]

, 2014
Magnetically induced ferroelectric multiferroics present an exciting new paradigm in the design of multifunctional materials, by intimately coupling magnetic and polar order.
Doig, K. I., Lloyd-Hughes, James, Lloyd-Hughes, J, Gaw, Stephen M., Gaw, SM, Doig, KI, Hétroy Wheeler, E. M., Boothroyd, AT, Hétroy Wheeler, EM, Prabhakaran, D, Boothroyd, Andrew T., Jones, S. P. P., Jones, SPP, Boothroyd, Andrew, Prabhakaran, Dharmalingam   +14 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Induced Polarization Imaging: A Geophysical Tool for the Identification of Unmarked Graves

Remote Sensing
The identification of unmarked graves is important in archaeology, forensics, and cemetery management, but invasive methods are often restricted due to ethical or cultural concerns. This necessitates the use of non-invasive geophysical techniques.
Matthias Steiner, Adrián Flores Orozco
doaj   +1 more source