Results 61 to 70 of about 216,890 (260)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Induced Polarization Imaging: A Geophysical Tool for the Identification of Unmarked Graves

Remote Sensing
The identification of unmarked graves is important in archaeology, forensics, and cemetery management, but invasive methods are often restricted due to ethical or cultural concerns. This necessitates the use of non-invasive geophysical techniques.
Matthias Steiner, Adrián Flores Orozco
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Geothermal Resource Exploration in Reshi Town by Integrated Geophysical Methods

Energies
Geothermal resources are a sustainable and valuable source of energy that offers considerable economic and social advantages. The present investigation centers on the accessibility of geothermal reservoirs in Reshi Town, Taoyuan County, Changde City ...
Ijaz Ahmed, Haifei Liu, Rujun Chen, Jawad Ahmad, Shahid Ali Shah, Shah Fahad, Osama Abdul Rahim, Farid Ullah, Li Rui   +8 more
doaj   +1 more source

Application of bipolar electrochemistry to follow electrochemical reactions at the semiconductor-electrolyte interface [PDF]

International Journal of Mining and Geo-Engineering
The properties of metallic minerals and metallic minerals-electrolyte interface have always been a concern in the induced polarization (IP) geophysical method due to their effects on the IP response.
Saeide Ahmadi, Ahmad Ghorbani, Hamid Reza Zare   +2 more
doaj   +1 more source

Pharmacological activation of rev-erbα suppresses LPS-induced macrophage M1 polarization and prevents pregnancy loss

BMC Immunology, 2021
Background Circadian rhythm is an important player for reproduction. Rev-erbα, a significant clock gene, is involved in regulating cell differentiation, inflammation and metabolism.
Liyuan Cui, Feng Xu, Songcun Wang, Xinyi Li, Haiyan Lin, Yan Ding, Meirong Du   +6 more
doaj   +1 more source

Spectral induced polarization porosimetry [PDF]

Geophysical Journal International, 2014
Induced polarization is a geophysical method looking to image and interpret low-frequency polarization mechanisms occurring in porous media. Below 10 kHz, the quadrature conductivity of metal-free sandy and clayey materials exhibits a distribution of relaxation times, which can be related to the pore size distribution of these porous materials.
Revil, A., Florsch, Nicolas, Camerlynck, Christian   +2 more
openaire   +3 more sources