Results 111 to 120 of about 2,784,794 (306)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
New advances in the science and use of Trichoderma spp.
浙江大学学报. 农业与生命科学版, 2004 Trichoderma spp. have been known for their strong abilities to produce extracellular enzymes, especially cellulases and glucanases by T. reesei, and also for their abilities to control plant pathogens. Most notably, a number of lines of evidence indicate
Gary Harman
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The Role of Potassium Phosphite in Enhancing the Activity of Defense Enzymes in Rice Infected by Sheath Blight [PDF]
پژوهشنامه اصلاح گیاهان زراعیExtended Abstract Background: Rice (Oryza sativa L.) serves as the primary food source for over half of the world's population. The disease caused by Rhizoctonia solani has significantly impeded rice production, resulting in substantial economic losses ...
Milad Habibi Daronkolaei +4 more
doaj
Obesity-Induced Inflammation and Insulin Resistance [PDF]
Frontiers in Endocrinology, 2014 Immune response and metabolic regulation are highly integrated and this interface maintains a central homeostatic system, dysfunction of which can cause obesity-associated metabolic disorder such as type 2 diabetes, fatty liver disease and cardiovascular disease. Insulin resistance is an underlying basis for the pathogenesis of these metabolic diseases.
openaire +4 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Modes of action of non-pathogenic strains of Fusarium oxysporum in controlling Fusarium wilts
Plant Protection Science, 2002 Many studies have demonstrated the capacity of non-pathogenic strains of F. oxysporum to control Fusarium diseases.These non-pathogenic strains show several modes of action contributing to their biocontrol capacity.
C. Alabouvette, Ch. Olivain
doaj +1 more source
, 2011 We report on theoretical studies of recently discovered microwave-induced resistance oscillations and zero resistance states in Hall bars with two occupied subbands.
B. K. Ridley +5 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source