Results 121 to 130 of about 1,397,977 (265)

How should APOBEC3-induced resistance mutations be considered in the management of antiretroviral therapy? [PDF]

J Antimicrob Chemother
Gilbert M, Ferré VM, Guilbaud R, Digumber M, Peytavin G, Damond F, Le Hingrat Q, Yazdanpanah Y, Descamps D, Charpentier C, Joly V, Ghosn J.   +11 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Chemically Induced Resistance to Pathogen Infection in Arabidopsis by Cytokinin (Trans-Zeatin) and an Aromatic Cytokinin Arabinoside. [PDF]

Mol Plant Pathol
Hönig M, Cortleven A, Petřík I, Simerský R, Bryksová M, Plíhal O, Schmülling T.   +6 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Editorial: The Plant Holobiont Volume II: Impacts of the Rhizosphere on Plant Health

Frontiers in Plant Science, 2021
Nadia Lombardi, Nadia Lombardi, Sheridan Lois Woo, Sheridan Lois Woo, Sheridan Lois Woo, Sheridan Lois Woo, Francesco Vinale, Francesco Vinale, Francesco Vinale, David Turrà, David Turrà, Roberta Marra, Roberta Marra   +12 more
doaj   +1 more source

Understanding MeJA induced-resistance to <i>Phytophthora cinnamomi</i> in holm oak embryogenic lines. [PDF]

Front Plant Sci
Morcillo M, Sanchez-Lucas R, Sales E, Jorrín-Novo J, Miedes E, Arrillaga I.   +5 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Mechanisms of Tetramycin-Induced Resistance to Rice Blast Disease in <i>Oryza sativa</i> L. [PDF]

Int J Mol Sci
Jiang H, Zhao C, Li D, Sun K, Xu Y, Pang K, Yu X, Shentu X.   +7 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Establishment of the Genetic Transformation System of <i>Trichoderma longibrachiatum</i> 40418 and Its Induced Resistance Against <i>Meloidogyne incognita</i> in Tomato. [PDF]

J Fungi (Basel)
Luo N, Wang C, Yin H, Guo W, Li H, Jiao Y.   +5 more
europepmc   +1 more source