Results 71 to 80 of about 7,682,818 (299)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Regrowth resistance: low-level platinum resistance mediated by rapid recovery from platinum-induced cell-cycle arrest [PDF]

, 2009
The H69CIS200 and H69OX400 cell lines are novel models of low-level platinum drug resistance developed from H69 human small cell lung cancer cells with eight 4-day treatments of 200 ng/ml cisplatin or 400 ng/ml oxaliplatin respectively. A recovery period
Ross Davey, Davey, Ross, Britta Stordal, Stordal, Britta   +3 more
core   +2 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Increasing Light Intensity Enhances Bacillus amyloliquefaciens PMB05-Mediated Plant Immunity and Improves Biocontrol of Bacterial Wilt

Agriculture
Bacterial wilt is a highly destructive disease affecting a wide range of crops, with no effective chemical control methods currently available. Consequently, the development of microbial strategies for disease management has become increasingly important.
Sin-Hua Li, Ai-Ting Li, Ming-Qiao Shi, Yi-Xuan Lu, Li-Ya Hong, Hsing-Ying Chung, Yi-Hsien Lin   +6 more
doaj   +1 more source

Erwinia carotovora subsp. carotovora and Erwinia-Derived Elicitors HrpN and PehA Trigger Distinct but Interacting Defense Responses and Cell Death in Arabidopsis

Molecular Plant-Microbe Interactions, 2003
We have used an hrp-positive strain of the soft rot pathogen Erwinia carotovora subsp. carotovora to elucidate plant responses to this bacterial necrotroph.
Tarja Kariola, Tiina A. Palomäki, Günter Brader, E. Tapio Palva   +3 more
doaj   +1 more source

Supranational surveillance of antimicrobial resistance: The legacy of the last decade and proposals for the future

, 2010
Antimicrobial resistance among clinically important bacteria is widely acknowledged as a major global public health threat. A decade ago, several supranational surveillance initiatives were introduced. Few of them are still ongoing, and only one features
CORNAGLIA, Giuseppe, Giske CG, European Study Group on Antimicrobial Resistance Surveillance, Christian G. Giske, Giuseppe Cornaglia, Cornaglia, G, Giske, CG   +6 more
core   +1 more source

Molecular mechanisms of insulin resistance in chronic liver disease [PDF]

, 2008
The work presented here analyses the role of PP2A in the dysregulation of glucose metabolism in the setting of chronic hepatitis C. We propose a new model for virus induced insulin resistance development through the overexpression of PP2A in the liver ...
Bernsmeier, Christine
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Plant phenotyping and root‐associated metabolomics reveal insights into pathogen protection by diverse arbuscular mycorrhizal fungi

Plants, People, Planet
Societal Impact Statement Arbuscular mycorrhizal (AM) fungi support plant development by enhancing growth and resistance to pathogens through mycorrhiza‐induced resistance (MIR).
Natascha V. Weinberger, Ximena Cibils‐Stewart, Chris Brien, Nathaniel Jewell, Bettina Berger, Timothy R. Cavagnaro, Matthias J. Salomon, Meena Mikhael, Jonathan M. Plett, Krista L. Plett, Jeff R. Powell   +10 more
doaj   +1 more source