Results 81 to 90 of about 6,757,588 (301)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Application of Pullulan to Induce Disease Resistance Against Diaporthe nobilis in Postharvest Kiwifruit

Food Frontiers
Kiwifruit stands out as a globally favored fruit owing to its palatable flavor and nutritional benefits. However, it continues to ripen after harvest, and this trait makes it more susceptible to fungal infections. Diaporthe spp.
Shukun Yu, Huanhuan Li, Lihong Han, Junjie Wang, Xiaofeng Tang, Zhao‐Jun Wei, Yongsheng Liu, Min Miao   +7 more
doaj   +1 more source

Harnessing microbial consortia for induced systemic resistance and sustainable management of dry root rot in cluster bean under hot arid climatic conditions

Frontiers in Microbiology
Dry root rot, caused by Macrophomina phaseolina, severely threatens cluster bean production, necessitating sustainable management strategies. This study aimed to screen, characterize and evaluate microbial isolates with antagonistic potential against M ...
Devendra Singh, Aman Verma, Kuldeep Singh Jadon, Hans Raj Mahla, Rajesh Kumar Kakani   +4 more
doaj   +1 more source

Caloric restriction induces anabolic resistance to resistance exercise

European Journal of Applied Physiology, 2020
Abstract Purpose Weight loss can result in the loss of muscle mass and bone mineral density. Resistance exercise is commonly prescribed to attenuate these effects. However, the anabolic endocrine response to resistance exercise during caloric restriction has not been characterized. Methods
Chaise Murphy, Karsten Koehler
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Waitea circinata: a novel biocontrol agent against Meloidogyne enterolobii on tomato plants

Journal of Nematology
Root-knot nematodes (RKN), particularly Meloidogyne enterolobii, pose a significant threat to agriculture, with current management heavily reliant on agrochemicals due to a scarcity of resistant crop varieties.
Alves Gianlucca de Urzêda, Felipe CG, Denner RF, Mara RR, Leila GA   +4 more
doaj   +1 more source

Endophytic fungus Beauveria bassiana induces antioxidant enzyme activities and enhances the growth of Rhizoctonia solani-infected potato plants

Вестник защиты растений
The physiological and biochemical changes in potato plants colonized by the endophytic form of the entomophatogenic fungus Beauveria bassiana (Ascomycota: Hypocreales) were analyzed under biotic stress caused by infection with the phytopathogen ...
О. Г. Томилова, Х. П. Толоконникова, М. В. Тюрин, Н. А. Крюкова   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Application of Sodium Silicate Enhances Cucumber Resistance to Fusarium Wilt and Alters Soil Microbial Communities

Frontiers in Plant Science, 2018
Exogenous silicates can enhance plant resistance to pathogens and change soil microbial communities. However, the relationship between changes in soil microbial communities and enhanced plant resistance remains unclear.
Xingang Zhou, Xingang Zhou, Yanhui Shen, Xuepeng Fu, Fengzhi Wu, Fengzhi Wu   +5 more
doaj   +1 more source