Results 241 to 250 of about 1,306,598 (296)

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Studies of the Impact of the Bifidobacterium Species on Inducible Nitric Oxide Synthase Expression and Nitric Oxide Production in Murine Macrophages of the BMDM Cell Line. [PDF]

Probiotics Antimicrob Proteins
Zabłocka A, Jakubczyk D, Leszczyńska K, Pacyga-Prus K, Macała J, Górska S.   +5 more
europepmc   +1 more source

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Inducible nitric oxide synthase and inflammation

Expert Opinion on Investigational Drugs, 1998
Nitric oxide (NO), derived from L-arginine (L-Arg) by the enzyme nitric oxide synthase (NOS), is involved in acute and chronic inflammatory events. In view of the complexity associated with the inflammatory response, the dissection of possible mechanisms by which NO modulates this response will be profitable in designing novel and more efficacious NOS ...
D, Salvemini, M H, Marino
openaire   +2 more sources

Inducible nitric oxide synthase in inflammation

The Histochemical Journal, 1995
Inflammation, the reaction of vascularized tissue to local injury, not only limits the effects of injury; it may also be the underlying pathological process which initiates or sustains disease. In this paper, the evidence is reviewed for a role for nitric oxide (NO) as a chemical indicator of inflammation and inflammatory diseases.
V, Cattell, A, Jansen
openaire   +2 more sources

Inducible nitric oxide synthase in the myocard

Molecular and Cellular Biochemistry, 2001
Recognition of significance of nitric oxide synthases (NOS) in cardiovascular regulations has led to intensive research and development of therapies focused on NOS as potential therapeutic targets. However, the NOS isoform profile of cardiac tissue and subcellular localization of NOS isoforms remain a matter of debate.
I B, Buchwalow, W, Schulze, P, Karczewski, M M, Kostic, G, Wallukat, R, Morwinski, E G, Krause, J, Müller, M, Paul, J, Slezak, F C, Luft, H, Haller   +11 more
openaire   +2 more sources

Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes

Journal of Neuroscience Research, 1997
It has been previously demonstrated that microglia and astrocytes produce micromolar amounts of nitric oxide in vitro. In this study, we demonstrate that primary rat oligodendrocytes can be stimulated to produce iNOS mRNA as detected by Northern blot and in situ hybridization analysis and a 131-kDa iNOS protein by Western blot analysis; protein was ...
J E, Merrill, S P, Murphy, B, Mitrovic, A, Mackenzie-Graham, J C, Dopp, M, Ding, J, Griscavage, L J, Ignarro, C J, Lowenstein   +8 more
openaire   +2 more sources

Inducible Nitric Oxide Synthase - Time for Reappraisal

Current Drug Target -Inflammation & Allergy, 2002
Inducible nitric oxide synthase (iNOS) is one of three key enzymes generating nitric oxide (NO) from the amino acid L-arginine. iNOS-derived NO plays an important role in numerous physiological and pathophysiological conditions, e.g. blood pressure regulation, inflammation, infection, and the onset and progression of malignant diseases.
Lirk, Philipp, Hoffmann, Georg, Rieder, Josef   +2 more
openaire   +3 more sources

Inducible Nitric Oxide Synthase Expression

Current Protocols in Toxicology, 2000
AbstractThis unit contains three protocols that can be used to determine iNOS expression in mouse macrophage‐like cells, RAW 264.7, by measuring end product, protein, and mRNA. A bacterial product, lipopolysaccharide (LPS), stimulates iNOS expression in RAW 264.7 cells.
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Inducible nitric oxide synthase aggresome formation is mediated by nitric oxide

Biochemical and Biophysical Research Communications, 2012
Nitric oxide (NO) generated by inducible NO synthase (iNOS) contributes critically to inflammatory injury and host defense. While previously thought as a soluble protein, iNOS was recently reported to form aggresomes inside cells. But what causes iNOS aggresome formation is unknown.
Tingting, Wang, Yong, Xia
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Immunobiology of Nitric Oxide and Regulation of Inducible Nitric Oxide Synthase

2017
Nitric oxide (NO) is a bioactive gas that has multiple roles in innate and adaptive immune responses. In macrophages, nitric oxide is produced by inducible nitric oxide synthase upon microbial and cytokine stimulation. It is needed for host defense against pathogens and for immune regulation.
Martin, Lee, Kevin, Rey, Katrina, Besler, Christine, Wang, Jonathan, Choy   +4 more
openaire   +2 more sources