Results 51 to 60 of about 1,306,598 (296)
Advanced Materials Interfaces, EarlyView.Fibrin–gelatin hydrogels functionalized with reduced graphene oxide create a mechanically stable and bioactive 3D environment for engineered cardiac tissue. The composite matrix promotes endothelial lumen formation, enhances sarcomeric protein expression, and increases contractile performance of embedded cardiomyocytes.
Christoph Kuckelkorn +5 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
wiley +1 more source
PLoS ONE, 2012 Neurogenesis continues in the adult brain and in the adult olfactory epithelium. The cytokine, leukaemia inhibitory factor and nitric oxide are both known to stimulate neuronal progenitor cell proliferation in the olfactory epithelium after injury.
Estefania Lopez-Arenas +3 more
doaj +1 more source
Journal of Pharmacological Sciences, 2011 .: Compelling evidence supports the notion that the majority of neurodegenerative diseases are associated with microglia-mediated neuroinflammation. Therefore, quelling of microglial activation may lead to neuronal cell survival.
Byung-Wook Kim +7 more
doaj +1 more source
Remote preconditioning by aortic constriction: affords cardioprotection as classical or other remote ischemic preconditioning? Role of iNOS [PDF]
, 2011 Dose remote preconditioning by aortic constriction (RPAC) affords cardioprotection similar to classical or other remote ischemic preconditioning stimulus?
Ashok Sharma +11 more
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The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]
Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Feelisch, Martin +3 more
core +1 more source
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Inducible nitric oxide synthase in human diseases
Clinical and Experimental Immunology, 1998 Since its discovery as a biologically active molecule in the late 1980s, nitric oxide (NO) has been found to play an important role as signal molecule in many parts of the organism as well as cytotoxic or regulatory effector molecule of the innate immune response.
K D, Kröncke +2 more
openaire +3 more sources
Inducible nitric oxide synthase and cardiovascular disease [PDF]
Cardiovascular Research, 2000 The simple gas nitric oxide (NO) has a diverse array of actions in numerous physiological and pathophysiological processes in the cardiovascular system. Three distinct NO synthase (NOS) isoforms, each encoded for by separate genes, have now been identified [1–4]. nNOS (or ‘neuronal’ NOS, NOS1) and eNOS (or ‘endothelial’ NOS, NOS3) are constitutive, Ca2+
openaire +2 more sources
Nitric oxide synthase in skeletal muscle fibres of patients with type 2 diabetes [PDF]
, 2012 Muscle-derived nitric oxide (NO) mediates fundamental physiological actions on skeletal muscle including glucose uptake into muscle cells. Recently, we have shown that the altered glucose metabolism in skeletal muscle of patients with type 2 diabetes ...
Karla Punkt +5 more
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