Results 41 to 50 of about 1,306,598 (296)
beta-Arrestin 2 is Required for B1 Receptor-Dependent Activation of Inducible Nitric Oxide Synthase.
, 2010 beta-Arrestin 2 is Required for B1 Receptor-Dependent Activation of Inducible Nitric Oxide ...
Frank K. Kuhr (7968128)
core +4 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez +12 more
wiley +1 more source
Inducible nitric oxide synthase modulates lipolysis in adipocytes
Journal of Lipid Research, 2005 The role of inducible nitric oxide synthase (iNOS) in the modulation of adipocyte lipolysis was investigated. Treatment of white and brown adipose cell lines and mouse adipose explants with a mixture of tumor necrosis factor-α, interferon-γ, and ...
Patrice Penfornis, André Marette
doaj +1 more source
Inducible nitric oxide synthase and vascular injury [PDF]
Cardiovascular Research, 1999 The role nitric oxide (NO) plays in the cardiovascular system is complex and diverse. Even more controversial is the role that the inducible NO synthase enzyme (iNOS) serves in mediating different aspects of cardiovascular pathophysiology. Following arterial injury, NO has been shown to serve many vasoprotective roles, including inhibition of platelet ...
M, Kibbe, T, Billiar, E, Tzeng
openaire +2 more sources
Atom‐Efficient Cerium‐Based Molecular Cages as Biocompatible Reactive Oxygen Scavengers
Advanced Healthcare Materials, EarlyView.Discrete mixed‐valent cerium molecular cages organize accessible redox centers within confined coordination environments and scavenge superoxide, hydrogen peroxide, and hydroxyl radicals. Encapsulation of the lead cage in an ROS‐responsive DTP nanoplatform enables lesion‐associated delivery, attenuates macrophage oxidative stress and inflammation, and ...
Chao Li +9 more
wiley +1 more source
Advances in Redox ResearchTumors characterized by a prominent desmoplastic stroma – including pancreatic ductal adenocarcinoma, the desmoplastic melanoma subtype, and a subset of triple-negative breast cancer feature a dense, collagen-rich stroma that impairs drug penetration ...
Ryan Sasse
doaj +1 more source
Cellular Protective Mechanisms Of Inducible Nitric Oxide Synthase
Redox Biology, 2015 The inducible nitric oxide synthase (iNOS) is expressed constitutively but also induced in a number of epithelial cell types. iNOS regulates a number of cellular processes in these cell types without exerting toxicity. Among these functions is protection
Timothy R. Billiar
doaj +1 more source
Striatal neuroinflammation promotes parkinsonism in rats [PDF]
, 2008 The specific role of neuroinflammation in the pathogenesis of Parkinson's disease remains to be fully elucidated. By infusing lipopolysaccharide (LPS) into the striatum, we investigated the effect of neuroinflammation on the dopamine nigrostriatal ...
Randy L Hunter +34 more
core +2 more sources
Magnetoactive Hydrogels to Probe Curvature‐Directed Endothelial Cell Mechanosensing
Advanced Healthcare Materials, EarlyView.This work establishes a platform to investigate local curvature as a regulator of endothelial mechanosensing independent of shear stress. Magnetoactive hydrogels enable on‐demand curvature of endothelial monolayers to reproduce tortuosity quantified by clinically established metrics.
Avinava Roy +6 more
wiley +1 more source