Results 51 to 60 of about 1,337 (291)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
PLoS ONE, 2019 In this study, we construct a paddle positioning system for defibrillation training simulators. The system consists of a chest manikin fabricated based on the standard somatotype of Koreans and simulator paddles similar to those of commercial ...
Young Seok Lee +4 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
A Singly Curved Conformal Phased Array with Integrated Particles-Based CRLH Phase Shifters
Electronics, 2023 In this paper, a four unit cell micron-sized magnetic particles embedded composite right/left-handed (CRLH) transmission line metamaterial phase shifter is proposed.
Muhammad Ayaz, Irfan Ullah
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A Novel Electric Spring With Improved Range of Operation for Isolated Microgrid Systems
IEEE Access, 2023 The smart load phenomenon of electric spring has been proven to be an important aid to the distribution network in terms of voltage stability. While the performance of ES is commendable, its operational range presents a significant challenge.
Soumya Mohanty +6 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Methods for Extension of Tunability Range in Synthetic Inductance Simulators
Elektronika ir Elektrotechnika, 2018 Presented work focuses on methods for the extended electronic control in the designs of inductance simulators based on single-loop feedback topology. Implementation is based on diamond transistors as voltage-to-current converters and two voltage-mode ...
Roman Sotner +5 more
doaj +1 more source