Results 61 to 70 of about 260,655 (288)
Validation of correlation-induction strategies for simulation experiments [PDF]
Proceedings of the 17th conference on Winter simulation - WSC '85, 1985 This paper develops a three-stage procedure for validating the use of the Schruben-Margolin correlation Induction strategy together with the follow-up analysis of Nozarl, Arnold, and Pegden in a simulation experiment designed to estimate a general linear model for the simulation response.
Jeffrey D. Tew, James R. Wilson
openaire +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Analytical Equivalent Circuit Extraction of Foreign Metal Objects in WPT Systems
IEEE AccessWireless power transfer (WPT) technologies are rapidly attracting attention because of their wide application field. Among them, inductive power transfer (IPT) technology is most promising for daily usage in households.
Ryo Shirai +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Investigating on Through Glass via Based RF Passives for 3-D Integration
IEEE Journal of the Electron Devices Society, 2018 Due to low dielectric loss and low cost, glass is developed as a promising material for advanced interposers in 2.5-D and 3-D integration. In this paper, through glass vias (TGVs) are used to implement inductors for minimal footprint and large quality ...
Libo Qian +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Energies, 2020 In this paper, an effective simulation method for lightning impulse voltage tests of reactor and transformer windings is presented. The method is started from the determination of the realized equivalent circuit of the considered winding in the wide ...
Piyapon Tuethong +2 more
doaj +1 more source