Results 41 to 50 of about 262,428 (237)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Effective Modeling of Leakage Inductance for use in Circuit Simulation
, 2008 Theoretical methods for the calculation of winding losses with respect to frequency have been well documented, but the variation in leakage inductance of magnetic components due to frequency has been less well addressed. In this paper Dowell’s well-known
Brown, Andrew, Wilson, Peter
core +2 more sources
Validation of correlation-induction strategies for simulation experiments [PDF]
Proceedings of the 17th conference on Winter simulation - WSC '85, 1985 This paper develops a three-stage procedure for validating the use of the Schruben-Margolin correlation Induction strategy together with the follow-up analysis of Nozarl, Arnold, and Pegden in a simulation experiment designed to estimate a general linear model for the simulation response.
Jeffrey D. Tew, James R. Wilson
openaire +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
PLoS ONE, 2019 In this study, we construct a paddle positioning system for defibrillation training simulators. The system consists of a chest manikin fabricated based on the standard somatotype of Koreans and simulator paddles similar to those of commercial ...
Young Seok Lee +4 more
doaj +1 more source
Materials Research Express, 2021 We designed, fabricated, and characterized microwave transmission properties with rewound strip structures for YBa _2 Cu _3 O _7 (YBCO)-based kinetic inductance detectors (KIDs).
Seiichiro Ariyoshi +6 more
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source