Results 41 to 50 of about 13,584 (301)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Development of Lumped Element Kinetic Inductance Detectors for NIKA [PDF]

, 2011
Lumped-element kinetic inductance detectors(LEKIDs) have recently shown considerable promise as direct absorption mm-wavelength detectors for astronomical applications.
Benoit, A., Bideaud, A., Boudou, N., Calvo, M., Cruciani, A., Doyle, S., Leclercq, S., Leduc, H. G., Mauskopf, P., Monfardini, A., Roesch, M., Schuster, K. F., Swenson, L.   +12 more
core   +1 more source

Using inductive counting to simulate nondeterministic computation

Information and Computation, 1993
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Buntrock, G., Hemachandra, L.A., Siefkes, D.   +2 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Design, Manufacturing and characterization of integrated inductors with magnetic layers for DC-DC converter

Advanced Electromagnetics, 2012
This paper presents the conception, fabrication and characterization of integrated inductors containing magnetic layers. We require different steps of micro-technologies: preparation of glass and ferrite substrates, RF sputtering, photolithography ...
D. Yaya, D. Allassem, M. Youssouf, A. Siblini, J. P. Chatelon, J. J. Rousseau   +5 more
doaj   +1 more source

Design evaluation of microwave transmission properties of YBa2Cu3O7-based kinetic inductance detectors

Materials Research Express, 2021
We designed, fabricated, and characterized microwave transmission properties with rewound strip structures for YBa _2 Cu _3 O _7 (YBCO)-based kinetic inductance detectors (KIDs).
Seiichiro Ariyoshi, Hikaru Mikami, Atsushi Ebata, Satoshi Ohnishi, Takeshi Hizawa, Saburo Tanaka, Kensuke Nakajima   +6 more
doaj   +1 more source

Realization of Resistorless Lossless Positive and Negative Grounded Inductor Simulators Using Single ZC-CCCITA [PDF]

, 2012
This paper is in continuation with the very recent work of Prasad et al. [14], wherein new realizations of grounded and floating positive inductor simulator using current differencing transconductance amplifier (CDTA) are reported. The focus of the paper
Herencsar, N., Koton, J., Lahiri, A., Metin, B., Vrba, K.   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source