Results 121 to 130 of about 2,572,407 (303)

Abduction: The Logic of Discovery of Grounded Theory

open access: yesForum: Qualitative Social Research, 2009
This essay is a contribution to the question whether grounded theory methodology (in the variant of STRAUSS & CORBIN) contains an abductive research logic as developed in the work of Charles Sanders PEIRCE.
Jo Reichertz
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Induction in Saturation

open access: yes
Abstract Proof by induction is commonplace in modern mathematics and computational logic. This paper overviews and discusses our recent results in turning saturation-based first-order theorem proving into a powerful framework for automating inductive reasoning.
Laura Kovács   +3 more
openaire   +1 more source

Specific Aspects Regarding Coupled Numerical Modeling of Inverter and Load Equipments in an Induction Heating Installation [PDF]

open access: yesJournal of Electrical and Electronics Engineering, 2008
The most propitious projection of inductiveelectrothermic installation requires a deep study ofcoupled electrothermic and circuits problems; thereforethe present paper follows the same line.
Claudiu MICH-VANCEA, Teodor LEUCA
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Tuberculosis in Malta : a case for sputum induction [PDF]

open access: yes, 2013
Sputum induction is a procedure used to help patients expectorate samples of sputum for laboratory analysis. It is a simple, safe and standardised procedure which may avoid the use of more invasive and potentially harmful interventions such as fibreoptic
Farrugia, Brian
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

From Color Induction to Brightness Induction

open access: yesThe Tohoku Journal of Experimental Medicine, 1958
Retinal induction was studied in the light-adapted human retina by the method of electrostimulation. 1. The properties of retinal induction are qualitatively the same as in the dark-adapted retina except that its dissipation is more rapid. 2. There is an optimal intensity of adapting light for production of retinal induction. 3.
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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