Results 121 to 130 of about 3,546,540 (364)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Navigating Drug–Drug Interactions in Clinical Drug Development: A Tutorial

open access: yesClinical and Translational Science
This tutorial provides essential guidelines and insights, in addition to regulatory guidance, for the evaluation of drug–drug interactions (DDIs), with a focus on the tools and timing of assessment critical for effective management of inclusion/exclusion
Jesmin Lohy Das   +2 more
doaj   +1 more source

Theory evaluation of the touchline media employee induction programme

open access: yes, 2009
Includes bibliographical references (leaves 39-41).This is a theory evaluation of the Touchline Media (TLM) employee induction programme. Organisations use induction training as part of the new employee welcoming process, making it one of the most common
Hendricks, Kenrick
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Demo 17-01 Electrostatic Induction

open access: yes, 2001
Two electrically isolated metal spheres are placed in contact, and a charged rod is held adjacent to one of the spheres as shown in Figure 1. When the spheres are separated, keeping the charged rod in its position as shown, they will carry equal and ...

core  

Artificial neural network prediction of weld distortion rectification using a travelling induction coil

open access: yes, 2013
An experimental investigation has been carried out to determine the applicability of an induction heating process with a travelling induction coil for the rectification of angular welding distortion.
Campbell, S. W.   +7 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome.

open access: yesScience, 1990
In tumor cells from virtually all patients with chronic myelogenous leukemia, the Philadelphia chromosome, a fusion of chromosomes 9 and 22, directs the synthesis of the P210bcr/abl protein.
G. Daley, R. A. Etten, D. Baltimore
semanticscholar   +1 more source

Development of an induction motor condition monitoring test rig And fault detection strategies

open access: yes, 2014
Includes bibliographical references.This thesis sets out to develop an induction motor condition monitoring test rig to experimentally simulate the common faults associated with induction motors and to develop strategies for detecting these faults that ...
Dlamini, Mpendulo
core  

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

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