Results 221 to 230 of about 1,332,541 (298)

Peripherally inserted central venous catheters for remission induction chemotherapy phase of acute leukemia: a single center experience in severely thrombocytopenic patients. [PDF]

Ann Hematol
Picardi M, Giordano C, Vincenzi A, Scarpa A, Pugliese N, Della Pepa R, Cimmino E, Persico M, Pane F.   +8 more
europepmc   +1 more source

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Colonization with extended-spectrum and AmpC β-lactamase-producing Enterobacterales and bacteremia risk in patients with acute leukemia who receive induction chemotherapy without fluoroquinolone prophylaxis. [PDF]

Antimicrob Agents Chemother
Stoeckle K, Sah Bandar I, Chen L, Douglass C, Davidson E, Hovan M, Derti S, La Spina M, Roboz GJ, Kaner J, Helfgott D, Kreiswirth BN, Westblade LF, Satlin MJ.   +13 more
europepmc   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

Phase II study of maintenance trifluridine/tipiracil (TAS-102) plus bevacizumab after induction chemotherapy in metastatic colorectal cancer. [PDF]

Oncologist
Ota K, Uemura M, Tanida T, Nakata K, Kudo T, Kagawa Y, Haraguchi N, Minami S, Matsuura Y, Ota H, Hiraki M, Yasui M, Takahashi H, Iwamoto K, Nishida N, Hata T, Nishizawa Y, Fukunaga M, Komori T, Takahashi Y, Tokuyama S, Tamagawa H, Naito A, Yoshihara T, Suzuki R, Sugimoto S, Miyake M, Takiguchi N, Tei M, Tamai K, Fukada A, Ogino T, Miyoshi N, Satoh T, Yamamoto H, Murata K, Doki Y, Eguchi H.   +37 more
europepmc   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Safety and efficacy of combining midostaurin and gemtuzumab ozogamicin with induction chemotherapy in FLT3-mutated AML. [PDF]

Blood Adv
Russell N, Othman J, Cumming O, Thomas A, Tedjaseputra A, Potter N, Jovanovic J, Gilkes A, Batten L, Canham J, Hinson E, Runglall M, Aucken P, Kottaridis P, Cavenagh J, Arnold C, Freeman S, Dennis M, Knapper S, Dillon R.   +19 more
europepmc   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

[¹⁷⁷Lu]Lu-DOTATATE Molecular Radiotherapy During Induction Chemotherapy for First-Line Stage 4 High-Risk Neuroblastoma in South African Children: Protocol for a Phase 1 Randomized Controlled Trial (LuDO-SA Trial). [PDF]

JMIR Res Protoc
van Heerden J, Kruger M, Reddy K, van Zyl A, Warwick J, Burger C, Moalosi T, van Reenen C, Davidson A, Hlongwa K, Violante D, Bruwer N, Naidu G, Rowe B, Louw L, van Wyk B, Vorster M, Mkhize T, Brink A.   +18 more
europepmc   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source