Results 51 to 60 of about 399,293 (360)

Optimizing survival outcomes with post-remission therapy in acute myeloid leukemia. [PDF]

, 2019
Optimization of post-remission therapies to maintain complete remission and prevent relapse is a major challenge in treating patients with acute myeloid leukemia (AML).
Chan, Steven M, Daver, Naval G, Jonas, Brian A, Medeiros, Bruno C, Pollyea, Daniel A   +4 more
core   +1 more source

Surgical salvage in patients with advanced testicular cancer: indications, risks and outcomes [PDF]

, 2020
The purpose of this review is to present a comprehensive and updated review of the literature and summary of the indications, risks and outcomes related to salvage, desperation and late relapse surgery for advanced testicular cancer.
Cary, Clint, Masterson, Timothy A., Speir, Ryan W.   +2 more
core   +1 more source

Results of complex treatment of patients with locally advanced squamous cell carcinoma of the paranasal sinuses and nasal cavity using induction chemotherapy

Опухоли головы и шеи, 2023
Introduction. About 600 new cases of malignant neoplasms of the paranasal sinuses and nasal cavity are detected annually in Russia. To date, there are no randomized trials to determine the optimal treatment algorithm for this group of patients.
T.   I. Dеshkina, L.  V. Bolotina, A.  R. Gevorkov, A.  V. Boyko, A.  L. Kornietskaya, A. P. Polyakov, P.   V. Golubev, R.  S. Sydykova, A. A. Fedenko   +8 more
doaj   +1 more source

The role of epithelial-to-mesenchymal plasticity in ovarian cancer progression and therapy resistance [PDF]

, 2019
Ovarian cancer is the most lethal of all gynecologic malignancies and the eighth leading cause of cancer-related deaths among women worldwide. The main reasons for this poor prognosis are late diagnosis; when the disease is already in an advanced stage ...
Berx, Geert, Denys, Hannelore, Loret, Nele, Tummers, Philippe   +3 more
core   +2 more sources

Chemoimmunotherapy as induction treatment in concurrent chemoradiotherapy for patients with nasopharyngeal carcinoma stage IVa

Annals of Medicine
Background Chemoimmunotherapy is the first-line therapy for patients with recurrent or metastatic nasopharyngeal carcinoma (NPC) and is currently the main induction treatment option for patients with locoregionally advanced NPC.
Kun-Peng Wu, Qing-Qing Li, Xu-Qiang Luo, Xiao-Xi Wang, Yan-Zhen Lai, Dan Tian, Hong-cheng Yang, Xue-Ling Wei, Lan-Ying Wang, Qiu-Ming Li, Dao Zhu, Si-Jie Chen, Yang-Si Li   +12 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Effect of induction chemotherapy on the quality-of-life in patients with advanced stage tongue cancer by a prospective study

Journal of International Medical Research, 2018
s Objective To assess how induction chemotherapy affects the quality-of-life (QoL) in patients with advanced tongue cancer. Methods This prospective study included patients who were diagnosed with advanced tongue cancer.
Tao Huang, Hui Liu, Pei Zhang, Yanxia Zhao   +3 more
doaj   +1 more source

Posaconazole for the prophylaxis of invasive aspergillosis in acute myeloid leukemia: Is it still useful outside the clinical trial setting?

Therapeutic Advances in Hematology, 2020
Background: Posaconazole prophylaxis during remission induction chemotherapy not only decreases the incidence of invasive aspergillosis (IA) but also improves the overall survival rate among patients with acute myeloid leukemia (AML). However, it remains
Tsung-Chih Chen, Ren Ching Wang, Yu-Hui Lin, Kuang-Hsi Chang, Li-Ya Hung, Chieh-Lin Jerry Teng   +5 more
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Comparing the benefits of chemoradiotherapy and chemotherapy for resectable stage III A/N2 non-small cell lung cancer: a meta-analysis

World Journal of Surgical Oncology, 2018
Background Induction chemotherapy has been shown to improve survival of patients with stage III A/N2 (T1–3, N2, M0) non-small cell lung cancer (NSCLC), followed by resection, but the benefits of neoadjuvant radiotherapy still remain controversial ...
Yuqiao Chen, Xiong Peng, Yuan Zhou, Kun Xia, Wei Zhuang   +4 more
doaj   +1 more source