Results 41 to 50 of about 262,962 (308)

DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer.

PLoS ONE, 2014
BackgroundInduction chemotherapy is a common therapeutic option for patients with locoregionally-advanced head and neck cancer (HNC), but it remains unclear which patients will benefit. In this study, we searched for biomarkers predicting the response of
Tanguy Y Seiwert, XiaoZhe Wang, Jana Heitmann, Vivian Villegas-Bergazzi, Kam Sprott, Stephen Finn, Esther O'Regan, Allan D Farrow, Ralph R Weichselbaum, Mark W Lingen, Ezra E W Cohen, Kerstin Stenson, David T Weaver, Everett E Vokes   +13 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Effect of Induction Chemotherapy in Nasopharyngeal Carcinoma: An Updated Meta-Analysis

Frontiers in Oncology, 2021
BackgroundPrevious meta-analysis had evaluated the effect of induction chemotherapy in nasopharyngeal carcinoma. But two trials with opposite findings were not included and the long-term result of another trial significantly differed from the preliminary
Shan-Shan Yang, Jian-Gui Guo, Jia-Ni Liu, Zhi-Qiao Liu, En-Ni Chen, Chun-Yan Chen, Pu-Yun OuYang, Fei Han, Fang-Yun Xie   +8 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth

, 2009
Background: Anti-cancer chemotherapy can be simultaneously lymphodepleting and immunostimulatory. Pre-clinical models clearly demonstrate that chemotherapy can synergize with immunotherapy, raising the question how the immune system can be mobilized to ...
Amy Prosser, Robinson, B.W.S., Currie, A.J., Scalzo, A.A., Joanne Salmons, Robbert G van der Most, Mark J Smyth, Bruce W S Robinson, Salmons, J., Lake, R.A., Smyth Mark J., Andrew J Currie, Amanda L Cleaver, Prosser, Amy, van der Most, R.G., Degli-Esposti, M.A., Salmons, Joanne, Lake, Richard A., Prosser, A., Prosser Amy, Nowak, A.K., Currie, Andrew J., van der Most Robbert G., Smyth, M.J., Robinson Bruce W. S., Lake Richard A., Degli-Esposti, Mariapia A., Scalzo Anthony A., Currie Andrew J., Nowak, Anna K., Sathish Mahendran, Cleaver, Amanda L., Richard A Lake, Nowak Anna K., van der Most, Robbert G., Larma, I., Mahendran, S., Anna K Nowak, Degli-Esposti Mariapia A., Anthony A Scalzo, Cleaver, A.L., Robinson, Bruce W.S., Larma, Irma, Irma Larma, Cleaver Amanda L., Smyth, Mark J., Larma Irma, Mehendran, Sathish, Scalzo, Anthony A., Salmons Joanne, Mahendran Sathish, Mariapia A Degli-Esposti   +51 more
core   +1 more source

Ifosfamide with regional hyperthermia in soft-tissue sarcomas [PDF]

, 2003
For high-risk soft tissue sarcomas (HR-STS) of adults, new treatment strategies are needed to improve outcome with regard to local control and overall survival.
M. Schlemmer, Wendtner, Clemens-Martin, C.M. Wendtner, R.D. Issels, Schlemmer, M., Issels, Rolf-Dieter   +5 more
core   +1 more source

Comparing the benefits of chemoradiotherapy and chemotherapy for resectable stage III A/N2 non-small cell lung cancer: a meta-analysis

World Journal of Surgical Oncology, 2018
Background Induction chemotherapy has been shown to improve survival of patients with stage III A/N2 (T1–3, N2, M0) non-small cell lung cancer (NSCLC), followed by resection, but the benefits of neoadjuvant radiotherapy still remain controversial ...
Yuqiao Chen, Xiong Peng, Yuan Zhou, Kun Xia, Wei Zhuang   +4 more
doaj   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Induction chemotherapy for unresectable urothelial carcinoma of the bladder

, 2010
• To analyse the outcome in selected patients with initially unresectable or minimally metastatic muscle-invasive urothelial bladder cancer who underwent induction chemotherapy (IC) followed by radical cystectomy (RC)
Oliver Gautschi, Gautschi, Oliver, Fiona C. Burkhard, George N. Thalmann, Urs E. Studer, Ghadjar, Pirus, Studer, Urs E, Pirus Ghadjar, Burkhard, Fiona C, Thalmann, George N   +9 more
core   +1 more source

Efficacy of docetaxel, cisplatin, and 5-fluorouracil as an induction chemotherapy in oral squamous cell carcinoma in a tertiary hospital in Saudi Arabia

Saudi Pharmaceutical Journal
Objective: To assess the efficacy and safety of the induction chemotherapy's combination of docetaxel, cisplatin, and 5-fluorouracil (TPF) in Oral Squamous Cell Carcinoma (OSCC) patients and its positive outcomes on tumor size and surgical resection ...
Mohammad Alessa, Abdullah A. Alhifany, Nouf A. Almatrafi, Ahmed S. Bahaj, Haddad H. Alkaf, Jabir Alharbi, Mohammed Y. Almaghrabi, Hemail M. Alsubaie, Hani Elkhatib, Faisal Albadainah, Sherif Abdelmonim   +10 more
doaj   +1 more source