Results 71 to 80 of about 262,962 (308)

Management of “Ultra-High Risk” gestational trophoblastic neoplasia at a tertiary center in India

Indian Journal of Medical and Paediatric Oncology, 2020
Aims: The aim of this study is to identify clinicopathological features associated with increased morbidity and mortality in cases of “ultra-high risk” gestational trophoblastic neoplasia (GTN) and to compare initial low-dose etoposide-cisplatin (EP ...
Shilpa M Patel, Ruchi Arora, Rajnish Tiwari, Pabashi Poddar, Ava Desai, Meeta H Mankad, Harsha Panchal   +6 more
doaj   +1 more source

Induction chemotherapy followed by definitive chemoradiotherapy versus chemoradiotherapy alone in esophageal squamous cell carcinoma: a randomized phase II trial

Nature Communications, 2021
The benefit of induction chemotherapy before definitive chemoradiotherapy (CRT) for patients with esophageal cancer is still uncertain. The results of this phase II randomized trial show that the addition of induction chemotherapy to CRT does not improve
Shiliang Liu, Liling Luo, Lei Zhao, Yujia Zhu, Hui Liu, Qiaoqiao Li, Ling Cai, Yonghong Hu, Bo Qiu, Li Zhang, Jingxian Shen, Yadi Yang, Mengzhong Liu, Mian Xi   +13 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Response assessment following induction chemotherapy and larynx preservation rates.

, 2022
Response assessment following induction chemotherapy and larynx preservation rates.
Alok Thakar (352079), Pirabu Sakthivel (4283353), Smriti Panda (4283347), Kurinchi S. Gurusamy (14192955), Atul Sharma (185929)   +4 more
core   +1 more source

Standard-Intensity Induction and Intermediate/High-Dose Cytarabine Consolidation Can Improve Survival for Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia: A Retrospective Cohort Study

Clinical Interventions in Aging, 2022
Li Wang, Na Zhao, Li Zhou, Juan Tong, Lei Xue, Lei Zhang, Yongsheng Han, Xingbing Wang, Liangquan Geng, Baolin Tang, Huilan Liu, Weibo Zhu, Xiaoyan Cai, Xin Liu, Xiaoyu Zhu, Zimin Sun, Changcheng Zheng Department of Hematology, The First Affiliated ...
Wang L, Zhao N, Zhou L, Tong J, Xue L, Zhang L, Han Y, Wang X, Geng L, Tang B, Liu H, Zhu W, Cai X, Liu X, Zhu X, Sun Z, Zheng C   +16 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Rebound Thrombocytosis after Induction Chemotherapy is a Strong Biomarker for Favorable Outcome in AML Patients [PDF]

, 2019
. Whereas the molecular events underlying acute myeloid leukemia (AML) are increasingly identified, dynamics of hematologic recovery following induction chemotherapy remain mysterious.
Urban Novak, Bianca R. Schnell, Pabst, Thomas, Barbara Jeker, Katja Seipel, Beatrice U. Mueller, Schnell, Bianca R., Thomas Pabst, Jeker, Barbara, Banz, Yara, Ulrike Bacher, Mueller, Beatrice U., Seipel, Katja, Bacher, Ulrike, Novak, Urban, Yara Banz   +15 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Taxane-cisplatin-fluorouracil as induction chemotherapy in locally advanced head and neck cancers : an individual patient data meta-analysis of the Meta-Analysis of Chemotherapy in Head and Neck Cancer Group

, 2013
: Purpose Cisplatin plus fluorouracil (PF) induction chemotherapy has been compared with taxane (docetaxel or paclitaxel), cisplatin, and fluorouracil (Tax-PF) in randomized trials in locoregionally advanced head and neck cancers (LAHNCs).
Vermorken, Jan Baptist, Lacas, Benjamin, Blanchard, Pierre, Bourhis, Jean, et al.   +4 more
core  

Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993

, 2005
The international acute lymphoblastic leukemia (ALL) study was designed to prospectively define the optimal therapy for adults 60 years of age or younger with newly diagnosed ALL.
Burnett, Alan Kenneth, Franklin, IM, Rowe, Jacob M., Richards, SM, Litzow, Mark R., Wiernik, P.H., Tallman, Martin S., Rowe, JM, Prentice, H. Grant, Goldstone, Anthony H., Wiernik, PH, Litzow, M.R., Litzow, MR, Ciobanu, N, Ciobanu, N., Prentice, HG, Durrant, J., Richards, Susan M., Durrant, J, Lazarus, H.M., Goldstone, A.H., Chopra, R, Lazarus, Hillard M., Wiernik, Peter H., Ciobanu, Niculae, Rowe, J.M., Tallman, MS, Durrant, Jill, Chopra, R., Lazarus, HM, Burnett, AK, Burnett, A.K., Buck, Georgina, Buck, G., Franklin, Ian M., Chopra, Raj, Goldstone, AH, Prentice, H.G., Richards, S.M., Tallman, M.S., Buck, G, Franklin, I.M.   +41 more
core   +1 more source