Results 101 to 110 of about 279,039 (336)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Исследование напряжений и деформаций в составном колесе электровагона при сборке с использованием комбинированного термического способа [PDF]

, 2001
On the basis of the available experimental data the systematic numerical research of one piece rolled railroad car wheel were made using technological heating by induction-heating devices which allowed the establishment of the laws of the stress-strain ...
Андреев, Арнольд Георгиевич, Иванова, В. Н., Оборский, И. Л., Щепкин, Александр Витальевич   +3 more
core  

Раціональне технологічне нагрівання при зборці колісних пар залізничного рухомого складу [PDF]

, 1998
On the basis of the available experimental data the systematic numerical research of one piece rolled railroad car wheel were made using technological heating by induction-heating devices which allowed the establishment of the laws of the stress-strain ...
Андрєєв, Арнольд Георгійович, Добровенський, Ю. М., Романов, С. В., Щепкін, Олександр Віталійович   +3 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

AUTOMATED HANDLING DEVICE FOR CILINDRICAL WORKPIECES USED FOR HIGH FREQUENCY INDUCTIONHARDENING EQUIPMENT

Nonconventional Technologies Review, 2017
Heating with high frequency induction has a large variety of applications like melting, heating and hardening metals. Heating by high frequency induction can be made in the complex automated manufacturing systems that can increase productivity and ...
Danut Pavel Tocut, Adrian Burca, Calin Tripe Vidican   +2 more
doaj  

Electromagnetic containerless processing requirements and recommended facility concept and capabilities for space lab [PDF]

Containerless melting, reaction, and solidification experiments and processes which potentially can lead to new understanding of material science and production of new or improved materials in the weightless space environment are reviewed in terms of ...
Bloom, H. L., Frost, R. T., Napaluch, L. J., Stockhoff, E. H., Wouch, G.   +4 more
core   +1 more source

Оптимизация технологического нагрева вагонного колеса при сборке колесной пары [PDF]

, 1998
On the basis of the available experimental data the systematic numerical research of one piece rolled railroad car wheel were made using technological heating by induction-heating devices which allowed the establishment of the laws of the stress-strain ...
Щепкин, Александр Витальевич
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Analysis of Heat Production in Induction Heating Irons

IEEJ Transactions on Fundamentals and Materials, 2004
The eddy currents in heating irons induced from ferrite-core induction coils are calculated using a theoretical approach and the results are compared with experimental data. Optimizations of components and materials for constructing the induction head are investigated to develop new type induction heating irons.
Shuji Obata, Hideo Tomita
openaire   +3 more sources