Results 81 to 90 of about 286,672 (306)

Deep Learning-Based Model Predictive Control for Resonant Power Converters

open access: yes, 2020
Resonant power converters offer improved levels of efficiency and power density. In order to implement such systems, advanced control techniques are required to take the most of the power converter.
Karg, Benjamin   +4 more
core   +1 more source

Analysis and simulations of multifrequency induction hardening [PDF]

open access: yes, 2013
We study a model for induction hardening of steel. The related differential system consists of a time domain vector potential formulation of the Maxwell's equations coupled with an internal energy balance and an ODE for the volume fraction of {\sl ...
Hoemberg, D., Petzold, T., Rocca, E.
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Continuous laser hardening with induction pre-heating [PDF]

open access: yes, 2014
A novel way of continuous surface hardening of steel bodies by a laser beam is modeled. This heat treatment is supplemented with pre-heating of the hardened parts by a classic inductor in order to reduce the temperature gradients and subsequent ...
Dolezel, I.   +3 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Rapid induction bonding of composites, plastics, and metals [PDF]

open access: yes
The Toroid Bonding Gun is and induction heating device. It is a self contained, portable, low powered induction welding system developed for bonding or joining plastic, ceramic, or metallic parts.
Buckley, John D., Fox, Robert L.
core   +1 more source

Three-Dimensional Atmospheric Circulation Models of HD 189733b and HD 209458b with Consistent Magnetic Drag and Ohmic Dissipation

open access: yes, 2013
We present the first three-dimensional circulation models for extrasolar gas giant atmospheres with geometrically and energetically consistent treatments of magnetic drag and ohmic dissipation.
Adams   +50 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

STRUCTURAL PARAMETER OPTIMIZATION OF LINE CONTACT STEEL STRAND INDUCTION HEATING COIL

open access: yesJixie qiangdu, 2016
The relationship between the size of inner diameter of induction heating coil and induction heating result was analyzed based on the transformer series equivalent circuit model of induction heating coil,the data of induction heating result under ...
CHENG YaPing, LI ZhiGang, ZHANG Qiang
doaj  

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