Results 71 to 80 of about 1,355,115 (303)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
INDUCTION HEATING IN HISTORY AND DEVELOPMENT. APPLICATION IN MODERN TRANSPORT REPAIRING TECHNOLOGIES [PDF]
Avtomobilʹnyj Transport (Harʹkov), 2017 The technologies used in repair of vehicles were analyzed in the given paper. The shortcomings of the mechanical repair methods in question can be solved by using induction heating.
Yu. Batyhin, O. Sabokar, V. Strelnikova
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 2007 Purpose - The paper aims to deal with the induction heating of metal billets rotating in a DC magnetic field. Design/methodology/approach - The induced power distributions are analysed and the main heating parameters are estimated with reference to an ...
LUPI, SERGIO +8 more
core +1 more source
MHD simulations of coronal heating [PDF]
, 2015 The problem of heating the solar corona requires the conversion of magnetic energy into thermal energy. Presently, there are two promising mechanisms for heating the solar corona: wave heating and nanoflare heating.
Tam, Kuan V.
core +2 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Single-source multiple-coil homogeneous induction heating
, 2017 This paper proposes and implements an approach to achieve homogeneous heating in a single-source multiple-coil induction heating system. In a traditional induction heating system, one of the key disadvantages is the inhomogeneous heating effect.
W. Han +13 more
core +2 more sources
Numerical Simulation of the Moving Induction Heating Process with Magnetic Flux Concentrator
Advances in Mechanical Engineering, 2013 The induction heating with ferromagnetic metal powder bonded magnetic flux concentrator (MPB-MFC) demonstrates more advantages in surface heating treatments of metal. However, the moving heating application is mostly applied in the industrial production.
Feng Li +3 more
doaj +1 more source