Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
A Combined Model and Data-Driven Approach for the Determination of Rotor Temperature in an Induction Machine. [PDF]
Sensors (Basel), 2021 Mocanu R, Onea A, Dosoftei CC.
europepmc +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
A Simple Linearization Method of Nonlinear Systems Based on Fuzzy Logic
IEEE AccessLinearization is a powerful tool that enables the analysis and control of nonlinear systems by simplifying their dynamics and allowing the use of well-established linear control techniques.
Daniela Perdukova +3 more
doaj +1 more source
Guaranteed State Estimation Using a Bundle of Interval Observers with Adaptive Gains Applied to the Induction Machine. [PDF]
Sensors (Basel), 2021 Schwartz M, Krebs S, Hohmann S.
europepmc +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Low-Computational-Cost Hybrid FEM-Analytical Induction Machine Model for the Diagnosis of Rotor Eccentricity, Based on Sparse Identification Techniques and Trigonometric Interpolation. [PDF]
Sensors (Basel), 2021 Terron-Santiago C +3 more
europepmc +1 more source
Machine learning and grammar induction [PDF]
Machine Learning, 1987 Despite its complexity, the task of natural language processing can be divided into a number of well-defined subtasks, and one of these centers on syntax. This aspect of language has been studied in detail by linguists, and developmental studies have provided a variety of empirical generalizations about the stages that children traverse in their ...
openaire +2 more sources
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source