Results 81 to 90 of about 103,994 (257)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A Simple Linearization Method of Nonlinear Systems Based on Fuzzy Logic

IEEE Access
Linearization is a powerful tool that enables the analysis and control of nonlinear systems by simplifying their dynamics and allowing the use of well-established linear control techniques.
Daniela Perdukova, Pavol Fedor, Martin Sobek, Jan Bacik   +3 more
doaj   +1 more source

A Combined Model and Data-Driven Approach for the Determination of Rotor Temperature in an Induction Machine. [PDF]

Sensors (Basel), 2021
Mocanu R, Onea A, Dosoftei CC.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Induction machine

, 2013
The aim of this paper is to present the difference of induction machine electromechanical characteristics in motor and generator operating modes. Firstly, the paper presents analytically derived equations, which are based on equivalent circuit and are used for calculation of induction machine breakdown torque.
Hadžiselimović, Miralem, Zagradišnik, Ivan, Štumberger, Bojan   +2 more
openaire   +1 more source

Guaranteed State Estimation Using a Bundle of Interval Observers with Adaptive Gains Applied to the Induction Machine. [PDF]

Sensors (Basel), 2021
Schwartz M, Krebs S, Hohmann S.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Challenges of the Optimization of a High-Speed Induction Machine for Naval Applications

Energies, 2019
In several industrial sectors, induction machines are being replaced with permanent magnet based alternatives, owing to the potential for higher power density and efficiency.
Giampaolo Buticchi, David Gerada, Luigi Alberti, Michael Galea, Pat Wheeler, Serhiy Bozhko, Sergei Peresada, He Zhang, Chengming Zhang, Chris Gerada   +9 more
doaj   +1 more source

Low-Computational-Cost Hybrid FEM-Analytical Induction Machine Model for the Diagnosis of Rotor Eccentricity, Based on Sparse Identification Techniques and Trigonometric Interpolation. [PDF]

Sensors (Basel), 2021
Terron-Santiago C, Martinez-Roman J, Puche-Panadero R, Sapena-Bano A.   +3 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source