Results 61 to 70 of about 176,937 (351)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hysteretic Regulators with Partially-Saturated Inductors

, 2018
This paper investigates the performances of partially-saturated ferrite power inductors in DC-DC hysteretic regulators. Exploiting inductors saturation allows reducing the volume and weight of switch-mode power supplies, provided that inductors ripple ...
Nicola Femia, Giulia Di Capua
core   +1 more source

Design of Interleaved Winding for Multilayer Planar Inductor and Its Application in Reducing Current Ringing of LLC Resonant Converter

Energies
To enhance the power density of LLC resonant converters, multilayer planar inductors are required. However, multilayer planar inductors have high parasitic capacitance, which may cause inductor current ringing in LLC resonant converters, leading to EMI ...
Qichen Liu, Zhengquan Zhang
doaj   +1 more source

Unified ZVS strategy for DAB with triple-phase-shift modulation in boost mode

The Journal of Engineering, 2019
In this study, the switching mode and working waveform of dual active bridge (DAB) converter under triple phase-shift modulation scheme is analysed, and an ALL-ZVS (zero voltage switching) control strategy of all devices for full-power range with voltage
Jian Qiu, Kai Shen, Anping Tong, Lijun Hang, Jiarui Liao   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Micromachined inductors and capacitors. [PDF]

, 2003
Made available in DSpace on 2012-11-02T21:15:12Z (GMT). No. of bitstreams: 2 license.txt: 4923 bytes, checksum: 3568ab34bde24044ec8ea05b1192aa03 (MD5) 6559653_opt.pdf: 6435533 bytes, checksum: 55a200e85ca95bbb24aad382e43718ef (MD5) Previous issue date:
Chen, Jack, Zou, Jun, Liu, Chang
core  

Fractional modelling and simulation for single-phase PWM rectifier

The Journal of Engineering, 2018
Modelling and analysis of single-phase PWM rectifier are usually based on integer order calculus theory, regardless of the fractional characteristics of inductors and capacitors, which will bring a deviation with the real system.
Pengfei Zhu, Yanfang Wei, Zheng Zheng, Xiaowei Wang, Fangjun Ma   +4 more
doaj   +1 more source

Ultra-Small, High-Frequency, and Substrate-Immune Microtube Inductors Transformed from 2D to 3D

Scientific Reports, 2015
Monolithic on-chip inductors are key passive devices in radio frequency integrated circuits (RFICs). Currently, 70–80% of the on-wafer area of most RFIC chips is occupied by the sprawling planar spiral inductors and its operation frequency is limited to ...
Xin Yu, Wen Huang, Moyang Li, T. Comberiate, S. Gong, J. Schutt-Ainé, Xiuling Li   +6 more
semanticscholar   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source