Results 121 to 130 of about 4,113,041 (291)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Relationship between Job Fatigue and Fine Motor Skills in Cable Car Company’s Production Staff [PDF]
Muhandisī-i bihdāsht-i ḥirfah/īBackground and Objective: Job fatigue is considered one of the factors affecting the performance and productivity of workers in work environments. Therefore, the objective of the present study was to investigate the relationship between job fatigue and ...
Mohammad Reza Shahahbi Kaseb +3 more
doaj
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Modern models of attracting investment in industrial projects
Вестник Северо-Кавказского федерального университетаIntroduction. The development of a mechanism for managing the investment process in industries is an urgent task for economists and practitioners in the current global economic situation.
Yu. Yu. Antashyan
doaj +1 more source
Is Working for a Start-up Worth It? Evidence from the Semiconductor Industry [PDF]
, 2007 This paper examines the long-term earnings implications of workers’ decisions to work for early-stage firms. Using quarterly data, 1990-2002, from the California Unemployment Insurance System covering workers in California’s semiconductor industry, I ...
Campbell, Benjamin
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Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Buffalo news : official newsletter of the Australian Buffalo Industry Council
, 2005 This publication contains may contain links to external sites.
Australian Buffalo Industry Council
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source