Results 121 to 130 of about 3,101,699 (290)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Other title: Wages and hours of women and minors in industry [PDF]
, 1938 At head of title: State of Kansas.; "This survey was taken by questionnaire in November and December, 1937. The questionnaire was mailed to over 7,000 employers in factories, mercantile establishments, packing houses, laundries, beauty parlors, hotels ...
Kansas. Department of Labor and Industry. Women's Division.
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Digital transformation of industrial business models: conceptual approaches and scenarios
π-EconomyUnder the influence of the deepening digitalization of the economy and society, the practice of digital transformation of business models in industry is expanding, aimed at creating new technological, economic and market competitive advantages for ...
Krakovskaia Irina
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Buffalo news : official newsletter of the Australian Buffalo Industry Council [PDF]
, 2010 This publication contains may contain links to external sites. These external sites may no longer be active.Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT).Official newsletter of the Australian Buffalo ...
Australian Buffalo Industry Council
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Buffalo news : official newsletter of the Australian Buffalo Industry Council [PDF]
, 2002 This publication contains may contain links to external sites. These external sites may no longer be active.Made available by the Northern Territory Library via the Publications (Legal Deposit) Act 2004 (NT).Official newsletter of the Australian Buffalo ...
Australian Buffalo Industry Council
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Bulletin de l’Association de Géographes FrançaisThe textile industry has helped to build industrial regions in France. After a period of crisis in the sector since the 1960s, the manufacturers who have continued in business have positioned themselves in niche markets (luxury, technical) and have ...
Mathieu Lembezat
doaj +1 more source